Cobalt Toxicity Induces Retinopathy and Optic Neuropathy in Mice
Basel Obied,
Stephen Richard,
Alon Zahavi
et al.
Abstract:To explore the effect of cobalt toxicity on vision.
METHODS.A total of 103 wild-type (WT) mice were injected with cobalt chloride by two routes in different concentrations: single intravenous (IV) high or low doses (total, n = 43); or daily repeated intraperitoneal (IP) high (three days) or low (28 days, 56 days) dose, and low-dose cobalt with added minocycline (56 days) (total, n = 60); 10 WT mice served as a control group. An additional group of 17 immunodeficient NOD scid gamma (NSG) mice were injected IV o… Show more
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