This article analyzes the media coverage of the COVID-19 vaccine by major media outlets in five Latin American countries: Argentina, Colombia, Chile, Mexico, and Peru. For this purpose, the XLM-roBERTa model was applied and the sentiments of all tweets published between January 2020 and June 2023 (n = 24,243) by the five outlets with the greatest online reach in each country were analyzed. The results show that the sentiment in the overall media and in each nation studied was mostly negative, and only at the beginning of the pandemic was there some positivity. In recent months, negative sentiment has increased twelvefold over positive sentiment, and has also garnered many more interactions than positive sentiment. The differences by platform and country are minimal, but there are markedly negative media, some more inclined to neutrality, and only one where positive sentiment predominates. This paper questions the role of journalism in Latin America during a health crisis as serious as that of the coronavirus, in which, instead of the expected neutrality, or even a certain message of hope, the media seem to have been dragged along by the negativity promoted by certain discourses far removed from scientific evidence.