Cocaine and accelerated atherosclerosis: insights from intravascular ultrasound

Erwin, Michael B.; Hoyle, John R.; Smith, C.H. Llewellyn; Deliargyris, Efthymios N.

doi:10.1016/s0167-5273(03)00170-0

Cited by 18 publications

(15 citation statements)

References 8 publications

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“…In our case, premature thrombogenic and atherosclerotic effect of cocaine consumption was confirmed [6]. Besides necropsy findings showed myocardial inflammation in combination with myocardial ischemic lesions.…”

Section: Discussionsupporting

confidence: 67%

Severe cardiomyopathy associated to cocaine abuse

Robledo-Carmona

Ortega-Jiménez

García‐Pinilla

et al. 2006

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 67%

Severe cardiomyopathy associated to cocaine abuse

Robledo-Carmona

Ortega-Jiménez

García‐Pinilla

et al. 2006

International Journal of Cardiology

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“…Autopsy reports have demonstrated accelerated atherosclerosis in young chronic cocaine users, a finding that has been extensively investigated in the cardiology literature (10). Although the mechanism is not clearly understood, it is thought to be related to the pro-atherosclerotic effects of cocaine on vascular endothelium, including a decrease in endothelial nitrous oxide production with subsequent enhancement of leukocyte migration as well as compromise of the endothelial barrier, allowing permeation of low-density lipoproteins into the subintimal space (10).…”

Section: Cocaine-related Complicationsmentioning

confidence: 99%

Your Brain on Drugs: Imaging of Drug-related Changes in the Central Nervous System

Tamrazi¹,

Almast²

2012

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Drug abuse is a substantial problem in society today and is associated with significant morbidity and mortality. Various drugs are associated with serious complications affecting the brain, and it is critical to recognize the imaging findings of these complications to provide prompt medical management. The central nervous system (CNS) is a target organ for drugs of abuse as well as specific prescribed medications. Drugs of abuse affecting the CNS include cocaine, heroin, alcohol, amphetamines, toluene, and cannabis. Prescribed medications or medical therapies that can affect the CNS include immunosuppressants, antiepileptics, nitrous oxide, and total parenteral nutrition. The CNS complications of these drugs include neurovascular complications, encephalopathy, atrophy, infection, changes in the corpus callosum, and other miscellaneous changes. Imaging abnormalities indicative of these complications can be appreciated at both magnetic resonance (MR) imaging and computed tomography (CT). It is critical for radiologists to recognize complications related to drugs of abuse as well as iatrogenic effects of various medications. Therefore, diagnostic imaging modalities such as MR imaging and CT can play a pivotal role in the recognition and timely management of drug-related complications in the CNS.

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“…Accelerated atheromatous lesion were found inside the wall of coronary arteries of long-term cocaine users who had few risk factors for atherosclerosis [7,8]. Foci myocarditis and fibrosis were found in the autopsies of chronic cocaine users [9][10][11][12]; cocaine-related left ventricular (LV) hypertrophy was found in both human [13] and experimental animals [14,15]; and cardiomyocyte apoptosis can be induced by cocaine at physiological levels [16].…”

Section: Introductionmentioning

confidence: 99%