Cocaine- and amphetamine-regulated transcript: a novel regulator of energy homeostasis expressed in a subpopulation of pancreatic islet cells

Gilon, Patrick

doi:10.1007/s00125-016-4052-y

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…Both CART precursors have been reported to be abundantly expressed in brain, pituitary and also in other peripheral tissues such as eye, interrenal tissues, and gonads in goldfish (39). CART exerts multiple physiological functions in fish, including the inhibition of appetite (39), regulation of the stress response (40) and energy balance (41).…”

Section: Hormones Regulating Food Intakementioning

confidence: 99%

Nutrient Regulation of Endocrine Factors Influencing Feeding and Growth in Fish

et al. 2019

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Endocrine factors regulate food intake and growth, two interlinked physiological processes critical for the proper development of organisms. Somatic growth is mainly regulated by growth hormone (GH) and insulin-like growth factors I and II (IGF-I and IGF-II) that act on target tissues, including muscle, and bones. Peptidyl hormones produced from the brain and peripheral tissues regulate feeding to meet metabolic demands. The GH-IGF system and hormones regulating appetite are regulated by both internal (indicating the metabolic status of the organism) and external (environmental) signals. Among the external signals, the most notable are diet availability and diet composition. Macronutrients and micronutrients act on several hormone-producing tissues to regulate the synthesis and secretion of appetite-regulating hormones and hormones of the GH-IGF system, eventually modulating growth and food intake. A comprehensive understanding of how nutrients regulate hormones is essential to design diet formulations that better modulate endogenous factors for the benefit of aquaculture to increase yield. This review will discuss the current knowledge on nutritional regulation of hormones modulating growth and food intake in fish.

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Section: Hormones Regulating Food Intakementioning

confidence: 99%

Nutrient Regulation of Endocrine Factors Influencing Feeding and Growth in Fish

et al. 2019

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“…In the pancreas, CART serves a physiological role in regulating both endocrine and exocrine pancreatic secretions (20). CART also regulates islet hormone secretion (21) and gastrointestinal tract motility (22). A previous study demonstrated that CART is positively associated with oxidative stress (23).…”

Section: Introductionmentioning

confidence: 99%

CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes

et al. 2021

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“…They decrease food intake and increase energy expenditure [3]. CART is widely expressed in the CNS, including brain regions controlling food intake, and direct administration of CART decreases food intake [4]. CART is believed to increase metabolism by causing an increase in the release of thyrotropin-releasing hormone (TRH) that in turn A. Webber-Waugh et al Journal of Behavioral and Brain Science stimulates release of thyroid stimulating hormone to cause an increase in heat production by muscle and adipose tissue [5].…”

Section: Introductionmentioning

confidence: 99%

Drug Seeking Behavior of Amphetamine Addicted Sprague-Dawley Rats Is Eliminated after Nutritional Supplementation

Webber-Waugh¹,

Nesbeth²,

Anderson-Johnson³

et al. 2017

JBBS

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Aim: The effectiveness of nutritional supplementation on drug-seeking behavior of amphetamine-addicted rats during withdrawal was investigated using a biased conditioned place preference (CPP) paradigm. Method: Twenty-four male Sprague-Dawley rats exhibiting baseline preference for the black chamber during a 20-minute pre-conditioning exploration of the CPP box completed the study. On alternate days of an 8-day schedule, twelve rats (Group AMP) were randomly selected, given either amphetamine sulfate (5 mg/ml, i.p.) and confined to the white chamber; or vehicle (1 ml saline, i.p.) and confined to the black chamber. A significant increased percentage time spent and number of entries made by Group AMP to the drug-paired, white chamber on the test day confirmed amphetamine addiction. Group AMP subsequently received increasing doses of amphetamine over 6 days. Following acute drug withdrawal, their CPP performance was compared with that of vehicle treated rats (Group SAL). Groups AMP and SAL were equally divided and randomly assigned to animals fed chow reconstituted with the nutritional supplement (AMP-S and SAL-S) over 8 weeks or standard rat chow (AMP-N and SAL-N). CPP performances for all rats were determined blindly from video recordings following this period. Results: Nutritionally supplemented, amphetamine withdrawn rats (AMP-S) exhibited significantly decreased percentage entries and time spent in the white chamber (p < 0.05), indicating preference for the black chamber and diminished drug-seeking behavior. ANOVA revealed that after 8 weeks of dietary supplementation, AMP-S rats behaved like drug-naïve, control animals. Conclusion: Drug-seeking behavior by amphetamine-addicHow to cite this paper:

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Cocaine- and amphetamine-regulated transcript: a novel regulator of energy homeostasis expressed in a subpopulation of pancreatic islet cells

Cited by 8 publications

References 32 publications

Nutrient Regulation of Endocrine Factors Influencing Feeding and Growth in Fish

Nutrient Regulation of Endocrine Factors Influencing Feeding and Growth in Fish

CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes

Drug Seeking Behavior of Amphetamine Addicted Sprague-Dawley Rats Is Eliminated after Nutritional Supplementation

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