1990
DOI: 10.1016/0379-0738(90)90105-8
|View full text |Cite
|
Sign up to set email alerts
|

Cocaine fatality: An unexplained blood concentration in a fatal overdose

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
18
0

Year Published

2007
2007
2022
2022

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 42 publications
(18 citation statements)
references
References 10 publications
0
18
0
Order By: Relevance
“…Multiple dosing is particularly relevant because recreational cocaine is often associated with binge use (Levine et al 1987;Ward et al 1997;Fischman and Schuster 1982). Toxic/lethal plasma cocaine concentrations average ∼20 µmol/L with an upper range of ∼80 µmol/L as determined in admitted patients (Winek et al 1987;Peretti et al 1990). Because these toxic/lethal plasma samples are obtained at times distant to the actual time of cocaine administration, and with a cocaine half-life of ∼40 min (Barnett et al 1981), much higher peak cocaine concentrations would be expected.…”
Section: Discussionmentioning
confidence: 99%
“…Multiple dosing is particularly relevant because recreational cocaine is often associated with binge use (Levine et al 1987;Ward et al 1997;Fischman and Schuster 1982). Toxic/lethal plasma cocaine concentrations average ∼20 µmol/L with an upper range of ∼80 µmol/L as determined in admitted patients (Winek et al 1987;Peretti et al 1990). Because these toxic/lethal plasma samples are obtained at times distant to the actual time of cocaine administration, and with a cocaine half-life of ∼40 min (Barnett et al 1981), much higher peak cocaine concentrations would be expected.…”
Section: Discussionmentioning
confidence: 99%
“…Earlier reports have indicated mean plasma cocaine concentration of 0.26±0.5 μM from a group of 111 cocaine users even though it could be as high as 120 μM [41] In another report Patel showed in 1996, that in a fatal case because of overdosing blood cocaine concentration was found to be 0.31 mM [42]. In yet another report of fatal case, >1mM cocaine was found to be present in blood [43]. Based on earlier studies, cocaine it is also known that CNS concentration could be as high as up to 155 times higher than that present in blood [44].…”
Section: Discussionmentioning
confidence: 99%
“…It is likely that many reported concentrations do not accurately reflect concentrations at the time of death [10]. Serum cocaine concentrations exceeding 1000 microM [11] have been reported following acute fatal overdose, although one series of 26 cases reported a mean concentration of 21 microM (range 0.3 to 70 microM) in deaths where cocaine was the only drug detected [12]. A second series compared cocaine concentrations of patients who died from trauma (and incidentally used cocaine) to cocaine concentrations of patients who died from cocaine poisoning.…”
Section: Cocaine Concentrations and Clinical Effectsmentioning
confidence: 99%