Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration

Festa, Eugene D.; Jenab, Shirzad; Weiner, Jan; Nazarian, Arbi; Niyomchai, Tipyamol; Russo, Scott J.; Kemen, Lynne M.; Akhavan, Alaleh; Wu, Hui-Bing K.; Quiñones-Jenab, Vanya

doi:10.1016/j.brainresbull.2005.08.023

Cited by 20 publications

(21 citation statements)

References 56 publications

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“…Consistent with this hypothesis, an investigation of healthy human subjects reported that drug-elicited DA release in the ventral striatum, caudate nucleus, and putamen was greater in male subjects compared with females (Munro et al, 2012). Additionally, a recent study showed that female smokers have significantly higher D2-like receptor availability than male smokers (Brown et al, 2012), further supporting the growing evidence of sex differences in dopaminergic system dynamics (Becker, 1999;Dreher et al, 2007;Festa et al, 2010;Hedges et al, 2010). On the other hand, the quinpirole-elicited yawning dose-response curve has been shown to be malleable to changes in food content and body weight (Baladi and France, 2009).…”

Section: Discussionmentioning

confidence: 70%

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys

Martelle

Nader

Czoty

et al. 2014

J Pharmacol Exp Ther

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The dopamine (DA) D 3 receptor (D3R) has been associated with impulsivity, pathologic gambling, and drug addiction, making it a potential target for pharmacotherapy development. Positron emission tomography studies using the D3R-preferring radioligand [ 11 C]PHNO ([ 11 C](+)-propyl-hexahydro-naphtho-oxazin) have shown higher binding potentials in drug abusers compared with control subjects. Preclinical studies have examined D3R receptor activation using the DA agonist quinpirole and the unconditioned behavior of yawning. However, the relationship between quinpirole-elicited yawning and D3R receptor availability has not been determined. In Experiment 1, eight drug-naive male rhesus monkeys were scanned with [ 11 C]PHNO, and the ability of quinpirole (0.01-0.3 mg/kg i.m.) to elicit yawning was examined. Significant positive (globus pallidus) and negative (caudate nucleus, putamen, ventral pallidum, and hippocampus) relationships between D3R receptor availability and quinpirole-induced yawns were noted. Experiment 2 replicated earlier findings that a history of cocaine self-administration (n = 11) did not affect quinpirole-induced yawning and extended this to examine monkeys (n = 3) with a history of methamphetamine (MA) selfadministration and found that monkeys with experience selfadministering MA showed greater potency and significantly higher quinpirole-elicited yawning compared with controls. Finally, quinpirole-elicited yawning was studied in drug-naive female monkeys (n = 6) and compared with drug-naive male monkeys (n = 8). Sex differences were noted, with quinpirole being more potent and eliciting significantly more yawns in males compared with females. Taken together these findings support the use of quinpirole-elicited yawning as a behavioral tool for examining D3R activation in monkeys and that both drug history and sex may influence individual sensitivity to the behavioral effects of D3R compounds.

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Section: Discussionmentioning

confidence: 70%

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys

Martelle

Nader

Czoty

et al. 2014

J Pharmacol Exp Ther

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“…For example, estrogen is known to enhance both basal and stimulant-induced DA release in the nucleus accumbens and striatum (Becker 1999), and to facilitate acquisition of cocaine self-administration (Lynch et al 2001;Hu et al 2004;Jackson et al 2006), and locomotor sensitization induced by repeated cocaine exposure in females (Hu and Becker 2003). Although there are divergent data on whether the density of D1 receptors in the nucleus accumbens differs between male and female rats (Festa et al 2006;Andersen and Teicher 2000), recent evidence suggests that D1 receptor blockade produces a more robust decrease in cocaine-induced locomotor behavior in female rats compared to male rats (Festa et al 2006). This finding is consistent with the hypothesis that D1 receptor-regulated signaling is enhanced in females compared to males and may contribute to sex differences in the behavioral effects of cocaine.…”

Section: Discussionmentioning

confidence: 98%

Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats

et al. 2006

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“…This may be due to sex differences in the pharmacokinetics of D1 signaling (Festa et al, 2004(Festa et al, , 2006, a possibility that could be addressed using a range of doses and time points between drug administration and extinction learning. Alternately, it may be the case that no change in extinction was detected in males because SKF administration moved their PFC function from slightly prepeak to slightly postpeak.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D1 Receptor Activation Rescues Extinction Impairments in Low-Estrogen Female Rats and Induces Cortical Layer-Specific Activation Changes in Prefrontal–Amygdala Circuits

Rey

Lipps

Shansky

2013

Neuropsychopharmacol

104

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Post-traumatic stress disorder (PTSD) is twice as common in women as in men; it is a major public health problem whose neurobiological basis is unknown. In preclinical studies using fear conditioning and extinction paradigms, women and female animals with low estrogen levels exhibit impaired extinction retrieval, but the mechanisms that underlie these hormone-based discrepancies have not been identified. There is much evidence that estrogen can modulate dopaminergic transmission, and here we tested the hypothesis that dopamine-estrogen interactions drive extinction processes in females. Intact male and female rats were trained on cued fear conditioning, and received an intraperitoneal injection of a D1 agonist or vehicle before extinction learning. As reported previously, females that underwent extinction during low estrogen estrous phases (estrus/metaestrus/diestrus (EMD)) froze more during extinction retrieval than those that had been in the high-estrogen phase (proestrus; PRO). However, D1 stimulation reversed this relationship, impairing extinction retrieval in PRO and enhancing it in EMD. We also combined retrograde tracing and fluorescent immunohistochemistry to measure c-fos expression in infralimbic (IL) projections to the basolateral area of the amygdala (BLA), a neural pathway known to be critical to extinction retrieval. Again we observed diverging, estrous-dependent effects; SKF treatment induced a positive correlation between freezing and IL-BLA circuit activation in EMD animals, and a negative correlation in PRO animals. These results show for the first time that hormone-dependent extinction deficits can be overcome with non-hormone-based interventions, and suggest a circuit-specific mechanism by which these behavioral effects occur.

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Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration

Cited by 20 publications

References 56 publications

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys

Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats

Dopamine D1 Receptor Activation Rescues Extinction Impairments in Low-Estrogen Female Rats and Induces Cortical Layer-Specific Activation Changes in Prefrontal–Amygdala Circuits

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Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration

Cited by 20 publications

References 56 publications

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D3 Receptor Activation in Male and Female Monkeys

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D3 Receptor Activation in Male and Female Monkeys

Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats

Dopamine D1 Receptor Activation Rescues Extinction Impairments in Low-Estrogen Female Rats and Induces Cortical Layer-Specific Activation Changes in Prefrontal–Amygdala Circuits

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Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys