Cocaine-related syndrome and palatal reconstruction: report of a series of cases

Cosola, Michele Di; Turco, M.; Acero, Julio; Navarro-Vila, Carlos; Cortelazzi, R

doi:10.1016/j.ijom.2007.03.015

Cited by 53 publications

(59 citation statements)

References 22 publications

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“…Vascular ischemia from excessive cocaine use is widely considered to be a major element in the development of CIMDL. [3][4][5][6][7][8] However, given the widespread abuse of nasal cocaine insufflation on the one hand and the relative rarity of CIMDL on the other, differentiating host factors must hold the key to the undoubtedly multifactorial pathogenesis of CIMDL. 20 The ischemic and direct traumatic effects of cocaine crystals should affect all users similarly.…”

Section: Discussionmentioning

confidence: 99%

“…The surgical procedures most often requested by patients are septal and palate perforation closure. [2][3][4][5][6][7][8][9] However, some patients ask for aesthetic procedures such as rhinoplasty and closure of nasocutaneous fistulas. 6,12,26 In the literature currently available, involvement of the craniovertebral junction or the spine in general in CIMDL has never been reported.…”

Section: Discussionmentioning

confidence: 99%

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Craniovertebral junction instability as an extension of cocaine-induced midline destructive lesions: case report

Brembilla¹,

Lanterna²,

Risso³

et al. 2015

SPI

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With the increasingly widespread illicit use of cocaine, a broad spectrum of clinical pathologies related to this form of drug abuse is emerging. The most frequently used method of administration of powdered cocaine is intranasal inhalation, or “snorting.” Consequently, adverse effects of cocaine on the nasal tract are common. Habitual nasal insufflations of cocaine can cause mucosal lesions. If cocaine use becomes chronic and compulsive, progressive damage of the mucosa and perichondrium leads to ischemic necrosis of the septal cartilage and perforation of the nasal septum. Occasionally, cocaine-induced lesions cause extensive destruction of the osteocartilaginous structures of the nose, sinuses, and palate and can mimic other diseases such as tumors, infections, and immunological diseases. In the literature currently available, involvement of the craniovertebral junction in the cocaine-induced midline destructive lesions (CIMDLs) has never been reported. The present case concerns a 44-year-old man who presented with long-standing symptoms including nasal obstruction, epistaxis, dysphagia, nasal reflux, and severe neck pain. A diagnosis of CIMDL was made in light of the patient’s history and the findings on physical and endoscopic examinations, imaging studies, and laboratory testing. Involvement of the craniovertebral junction in the destructive process was evident. For neurosurgical treatment, the authors considered the high grade of atlantoaxial instability, the poorly understood cocaine-induced lesions of the spine and their potential evolution overtime, as well as cocaine abusers’ poor compliance. The patient underwent posterior craniovertebral fixation. Understanding, classifying, and treating cocaine-induced lesions involving the craniovertebral junction are a challenge.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Craniovertebral junction instability as an extension of cocaine-induced midline destructive lesions: case report

Brembilla¹,

Lanterna²,

Risso³

et al. 2015

SPI

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“…This, and the traumatic effect of the crystals inhaled at high speed, favor the appearance of recurrent nasal infections. This situation contributes to chronic tissue destruction (7,12). According to Jewers et al, another possible pathogenic mechanism is the presence of opiate receptors in macrophages and lymphocytes, causing immune alterations that would favor bacterial and fungal invasion (13).…”

Section: Discussionmentioning

confidence: 99%

“…The associated neurological disorders in turn include cluster headache. On the other hand, individuals who frequently consume the drug tend to experience severe bruxism, with an increased incidence of joint and myofascial pain (3,7,9). The systemic complications of cocaine abuse in turn include arrhythmias, acute myocardial infarction, stroke, bronchospasm, pneumothorax, etc.…”

Section: Discussionmentioning

confidence: 99%

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Palatal perforations secondary to inhaled cocaine abuse. Presentation of five cases

Sanchez¹,

Sebastián²,

Soriano³

et al. 2010

J Clin Exp Dent

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The estimated incidence of complications associated with cocaine abuse is 4.8%. Palatal perforation is a very infrequent condition within the range of complications associated with cocaine abuse. No epidemiological characteristics relating to patient age or gender have been established, and the diagnosis of the disorder requires a detailed clinical history, including antecedents of cocaine abuse. The clinical and radiological studies show palatal bone erosion and perforation of the soft or hard palate. The present study describes five cases of palatal perforation secondary to inhaled cocaine abuse. As a result of the increase in cocaine use in recent years, particularly among young adults, clinicians must be alerted to the need to include this condition when establishing a differential diagnosis.Key words: Cocaine, palatal perforation, inhalation, oronasal communication.

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Velopharyngeal dysfunction from intranasal substance abuse: Case series and review of literature

et al. 2018

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Cocaine-related syndrome and palatal reconstruction: report of a series of cases

Cited by 53 publications

References 22 publications

Craniovertebral junction instability as an extension of cocaine-induced midline destructive lesions: case report

Craniovertebral junction instability as an extension of cocaine-induced midline destructive lesions: case report

Palatal perforations secondary to inhaled cocaine abuse. Presentation of five cases

Velopharyngeal dysfunction from intranasal substance abuse: Case series and review of literature

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