Cocamidopropyl betaine is commonly found in hypoallergenic personal care products for children

Abstract

more than 120 days after the last ustekinumab treatment were excluded. Finally, 3 patients were considered to have active tuberculosis related to ustekinumab treatment. The duration of ustekinumab treatment before diagnosis of active tuberculosis in these 3 patients was 53, 1046, and 1280 days (Supplemental Table II). There was neither active nor latent tuberculosis within 3 years before first ustekinumab treatment in these 3 patients. Sex-and age-adjusted expected number of active tuberculosis cases from 2803 patients was 3.945; thus, the standardized incidence ratio was 0.76 compared with that in the general population (95% confidence interval 0.59-2.02).This study showed that ustekinumab did not increase the risk of tuberculosis compared with that among the general population in an actual clinical setting in South Korea. Similarly, Hsiao et al 5 reported no active tuberculosis infection in 134 psoriatic patients receiving ustekinumab in Taiwan. Thus, these results suggest that ustekinumab treatment does not require additional tuberculosis monitoring even in areas with high disease burden. Further studies from other regions are needed to validate these results.

Changes in Product Use and Quality of Life After Patch Testing in Children With Allergic Contact Dermatitis: A Follow-up Survey

“…Previous literature has shown that even household products branded as "hypoallergenic" can contain ingredients that are prevalent allergens, such as cocamidopropyl betaine. 3,4 One retrospective study on 1142 children found that over-the-counter products branded as "gentle skin care" still often provoke symptoms of dermatitis. 5 Furthermore, recent prospective studies have demonstrated that patients often struggle to understand and recall the results of a patch test, especially those diagnosed with multiple allergens.…”

“…However, avoidance of allergens, even once identified, can be challenging. Previous literature has shown that even household products branded as “hypoallergenic” can contain ingredients that are prevalent allergens, such as cocamidopropyl betaine 3,4 . One retrospective study on 1142 children found that over-the-counter products branded as “gentle skin care” still often provoke symptoms of dermatitis 5 .…”

Baby wipes and nappy rash – what is the relationship? A review

“…Allergic reactions were found to be mostly due to a contaminant in manufacture, DMAP, and reaction levels dropped with its removal. However, CAPB remains a cause of irritation and an article written by Collis in 2020 found it in marketed “hypoallergenic” wet wipes in the USA 29 . Another class of gentle surfactants, alkyl glucosides, is present in many brands of baby wipes, amongst other cosmetics 11 .…”

“…However, CAPB remains a cause of irritation and an article written by Collis in 2020 found it in marketed "hypoallergenic" wet wipes in the USA. 29 Another class of gentle surfactants, alkyl glucosides, is present in many brands of baby wipes, amongst other cosmetics. 11 There has been a slow and steady increase in sensitisation since 2003, and the rates will continue to grow making them an emerging class of allergens to be aware of.…”

What We Have Learned–Milestones in Pediatric Contact Dermatitis

“…In one Polish study, CAPB was present in 30% of the analyzed 212 skin care products marketed for children 0–12 months of age [ 16 ]. It was also found to be an ingredient in a high proportion of “hypoallergenic” personal products for children [ 24 ]. Studies have also suggested a greater incidence of sensitization to CAPB in patients with atopic dermatitis [ 25 ].…”