Coccidioidomycosis in Northern Arizona: an Investigation of the Host, Pathogen, and Environment Using a Disease Triangle Approach

Mead, Heather; Kollath, Daniel R.; Teixeira, Marcus de Melo; Roe, Chandler C.; Plude, Carmel; Nandurkar, Nivedita; Donohoo, Chelsea; O'Connor, Brettania L. W.; Terriquez, Joel; Keim, Paul; Barker, Bridget M.

doi:10.1128/msphere.00352-22

Cited by 3 publications

(2 citation statements)

References 86 publications

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“…The association with Histoplasma species and bat and bird manure is well established; however, the soil pH, land cover, and distance from water may impact the distribution, but more data are needed [ 36 , 37 ]. Although unanswered questions remain about the environmental habitats of all endemic fungi, this knowledge gap is especially severe for Blastomyces species [ 34 , 35 , 37 , 38 , 39 ]. Very little is known about where Blastomyces species occur in the environment and how people are exposed.…”

Section: Disease-specific Priorities ( Table 2 )mentioning

confidence: 99%

Public Health Research Priorities for Fungal Diseases: A Multidisciplinary Approach to Save Lives

Smith

Gold

Benedict

et al. 2023

JoF

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Fungal infections can cause severe disease and death and impose a substantial economic burden on healthcare systems. Public health research requires a multidisciplinary approach and is essential to help save lives and prevent disability from fungal diseases. In this manuscript, we outline the main public health research priorities for fungal diseases, including the measurement of the fungal disease burden and distribution and the need for improved diagnostics, therapeutics, and vaccines. Characterizing the public health, economic, health system, and individual burden caused by fungal diseases can provide critical insights to promote better prevention and treatment. The development and validation of fungal diagnostic tests that are rapid, accurate, and cost-effective can improve testing practices. Understanding best practices for antifungal prophylaxis can optimize prevention in at-risk populations, while research on antifungal resistance can improve patient outcomes. Investment in vaccines may eliminate certain fungal diseases or lower incidence and mortality. Public health research priorities and approaches may vary by fungal pathogen.

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Section: Disease-specific Priorities ( Table 2 )mentioning

confidence: 99%

Public Health Research Priorities for Fungal Diseases: A Multidisciplinary Approach to Save Lives

Smith

Gold

Benedict

et al. 2023

JoF

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“…Coccidioidomycosis (CM), often referred to as Valley fever because it was found to be endemic in the Southern San Joaquin Valley of California [1], is an increasingly important systemic fungal infection in the United States [2,3], elsewhere in the Western Hemisphere [4], and, because of travel, virtually anywhere else in the world [5]. The fungi Coccidioides immitis or Coccidioides posadasii, which cause CM, reside sparsely in the soil of endemic regions [6]. When the soil is disrupted, single-cell fragments of mycelia (arthronidia) are dispersed and may remain airborne for long periods of time and potentially travel over extensive distances [7].…”

Section: Introductionmentioning

confidence: 99%

Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective

Galgiani

Hsu

Powell

et al. 2023

JoF

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The endemic fungal infection, coccidioidomycosis, occurs after inhalation of one or very few Coccidioides spp. spores. Infections produce diverse clinical manifestations, ranging from insignificant to extremely destructive, even fatal. Approaches to understanding this range of consequences have traditionally categorized patients into a small number of groups (asymptomatic, uncomplicated self-limited, fibro-cavitary, and extra-thoracic disseminated) and then looked for immunologic differences among them. Recently, variants within genes of innate pathways have been found to account, in part, for infections that result in disseminated disease. This discovery raises the very attractive theory that, in patients without severe immunosuppression, much of the disease spectrum can be accounted for by various combinations of such deleterious variants in innate pathways. In this review, we summarize what is known about genetic determinants that are responsible for the severity of coccidioidal infections and how complex innate genetic differences among different people might account for the spectrum of disease observed clinically.

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Valley fever under a changing climate in the United States

Howard,

Sayes,

Giesy

et al. 2024

Environment International

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Coccidioidomycosis in Northern Arizona: an Investigation of the Host, Pathogen, and Environment Using a Disease Triangle Approach

Cited by 3 publications

References 86 publications

Public Health Research Priorities for Fungal Diseases: A Multidisciplinary Approach to Save Lives

Public Health Research Priorities for Fungal Diseases: A Multidisciplinary Approach to Save Lives

Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective

Valley fever under a changing climate in the United States

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