2019
DOI: 10.1152/jn.00677.2018
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Cochlear compound action potentials from high-level tone bursts originate from wide cochlear regions that are offset toward the most sensitive cochlear region

Abstract: Little is known about the spatial origins of auditory nerve (AN) compound action potentials (CAPs) evoked by moderate to intense sounds. We studied the spatial origins of AN CAPs evoked by 2- to 16-kHz tone bursts at several sound levels by slowly injecting kainic acid solution into the cochlear apex of anesthetized guinea pigs. As the solution flowed from apex to base, it sequentially reduced CAP responses from low- to high-frequency cochlear regions. The times at which CAPs were reduced, combined with the co… Show more

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Cited by 17 publications
(38 citation statements)
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“…Tone-pip-evoked auditory-nerve CAPs provide frequency-specific objective measures of cochlear neural sensitivity 10 . In eight control (un-operated) animals, the perfusion times at which the CAP amplitudes from low-level tone bursts were reduced to 50% of their original values showed when the perfusion front reached the CF region of the tone 10 . We used animals of either sex weighing ≥ 400 g. In the five sac-surgery animals, the 50% reduction times were earlier , on average, than the 50% reduction times of the eight control animals (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Tone-pip-evoked auditory-nerve CAPs provide frequency-specific objective measures of cochlear neural sensitivity 10 . In eight control (un-operated) animals, the perfusion times at which the CAP amplitudes from low-level tone bursts were reduced to 50% of their original values showed when the perfusion front reached the CF region of the tone 10 . We used animals of either sex weighing ≥ 400 g. In the five sac-surgery animals, the 50% reduction times were earlier , on average, than the 50% reduction times of the eight control animals (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…At 30 days after the operation, operated ears had normal hearing thresholds at high frequencies and a hearing loss at low frequencies 8 , 9 , a pattern found in early-stage Ménière’s disease 3 . By using a cochlear perfusion technique that enables assessment of tonotopicity 10 , 11 , we show, for the first time, abnormal cochlear frequency-place maps in ears that developed normally but have been changed by a disease process (endolymphatic hydrops).…”
Section: Introductionmentioning
confidence: 92%
“…43 Recent research studying the origins of auditory nerve action potential responses for high-level sounds shows spectral splatter exciting nerve fibers over a wide frequency range, yet none of these mechanisms fully explain the influence of blood lipid levels on pure tone thresholds specific to any frequency. 44…”
Section: Discussionmentioning
confidence: 99%
“…Cochlear responses to threshold-level tones define the tonotopic map (Müller et al, 2005). As SPL increases, the region of excitation broadens, and the focal region of excitation shifts toward mid-frequency regions corresponding to the center of the threshold audiogram (Lee et al, 2019). As 8 -16 kHz is a relatively low-frequency range for mouse, with increasing SPL, the focal region broadens and shifts from more apical cochlear regions toward higher-frequency regions in the cochlear base (see Fig.…”
Section: Methodsmentioning
confidence: 99%