Cochlear Damages Caused by Vibration Exposure

Najarkola, Seyyed Ali Moussavi; Khavanin, Ali; Mirzaei, Ramazan; Salehnia, Mojdeh; Muhammadnejad, Ahad

doi:10.5812/ircmj.5369

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…[13]. This study uses DPOAE (Distortion Product Otoacoustic Emission) which is a response that occurs when the cochlea is stimulated simultaneously by two pure tones with a frequency ratio of 1.25 [14]. The results of the signal to noise ratio (SNR) are used as an indicator to assess inner ear damage in hearing loss incidence [15].…”

Section: Introductionmentioning

confidence: 99%

Correlation of SNR Value on DPOAE Examination with HSP70 Levels in Blood and HSP70 Expression in Cochlea of Noise Model Rattus norvegicus as an Indicator of Inner Ear Damage

Pratiwi,

Haryuna,

Adriztina

et al. 2024

Adv. life sci.

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Background: Cellular stress caused by noise-induced hearing loss can be observed through the damage of cochlear hair cells, mechanically and metabolically. SNR value on the DPOAE examination assesses the sensory function of cochlear outer hair cells. HSP70 as marker of cellular stress can be identified from its levels in blood and its expression in the cochlea.Methods: Three groups of rats were used for the noise intervention: Group 1 was the control group, Group 2 had a noise exposure of 100 dB, and Group 3 received a noise exposure of 110 dB. DPOAE examination was then conducted, blood samples from rats’ tail were collected after a noise treatment, followed by the measurement of HSP70 levels by ELISA readings. Rats were terminated afterwards and immunohistochemical examination of the cochlear organ of Corti was performed to calculate the expression of HSP70. The data obtained were analyzed using SPSS.Results: A decrease occurred in the values of SNR and an increase occurred in HSP70 levels in blood along with its expression in the cochlea of noise model Rattus norvegicus, and there is a correlation between the three.Conclusion: The decrease in SNR values, increase in HSP70 levels in blood, and increase in HSP70 expression in the cochlear organ of Corti of Rattus norvegicus, proves that noise-induced hearing loss triggers the production of HSP70 as a cytoprotective agent in preventing inner ear damage.Keywords: DPOAE; Rattus norvegicus; NIHL; Heat Shock Protein 70

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Section: Introductionmentioning

confidence: 99%

Correlation of SNR Value on DPOAE Examination with HSP70 Levels in Blood and HSP70 Expression in Cochlea of Noise Model Rattus norvegicus as an Indicator of Inner Ear Damage

Pratiwi,

Haryuna,

Adriztina

et al. 2024

Adv. life sci.

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“…Rabbits have been used as one of the most frequently used experimental animal models for otic studies in ototoxicity (D'yakonova et al, 2017), noise‐induced hearing loss (Luebke et al, 2014; Moussavi‐Najarkola et al, 2012), age‐related hearing loss (presbycusis) (Bhattacharyya & Dayal, 1989) and audiology (Martin et al, 2016; Peacock et al, 2015) researches. Anatomically, the description of the rabbit ear is primarily described in terms of the external ear (Farag, 2008) and middle ear (Guan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Anatomy of the rabbit inner ear using computed tomography and magnetic resonance imaging

El-Hameed

El-Shafey

Metwally

et al. 2023

Anat Histol Embryol

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Anatomically, the inner ear is a highly complex organ of intricate design, composed of a bony labyrinth that encases the same-shaped membranous labyrinth. It is difficult to study the three-dimensional anatomy of the inner ear because the relevant structures are very small and embedded within the petrous temporal bone, one of the densest bones in the body. The current study aimed to provide a detailed anatomic reference for the normal anatomy of the rabbit's inner ear. As a study model, ten healthy adults New Zealand White rabbit heads were used. Six heads were used for macroscopic evaluation of the bony and membranous labyrinths. The remaining four heads were evaluated radiographically, where 3D images were generated of the bony and membranous labyrinths using data sets from computed tomography (CT) and magnetic resonance imaging (MRI), respectively. The anatomical structures were identified and labelled according to NominaAnatomicaVeterinaria (NAV). Our study revealed that CT and MRI are the optimal cross-sectional imaging modalities for investigating such tiny and often inaccessible inner ear structures. As high-quality scanners are not readily available to veterinarians, the CT and MRI images generated by this research were of lower quality; therefore, high-quality dissections were used to identify/support structures seen in these images. In conclusion, this study provides one of the first investigations that uses multislice CT scans and MRI to study the rabbit's inner ear and its correlation with the corresponding anatomical images. Both anatomical, CT and MRI images will serve as a reference for interpreting pathologies relative to the rabbit's inner ear.

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“…The human auditory system undergoes physiological changes due to noise exposure, specifically outer hair cells (OHCs) causing permanent or temporary damage to the structures and functionally, resulting in decreased auditory sensitivity. 3 This type of noise exposure typically results in damage at higher frequencies, commonly affecting the region between 3 and 4 kHz. 4 To regulate these effects, Occupational Safety and Health Administration has set the permissible sound pressure level at 85 decibel A (dBA) for an exposure duration of 8 hours.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Saccular Function in Nonmusicians and Violinists Using cVEMP: A Pilot Study

D’Souza

Yerraguntla

2021

Annals of Otology and Neurotology

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Introduction Human auditory and vestibular systems change due to noise exposure. Professional musicians are often subjected to loud music and longer durations as part of their practice. Although the effects of music have been explored extensively on the auditory system, it is important to understand changes in the vestibular system also. The current study is aimed to compare cervical vestibular evoked myogenic potential (cVEMP) findings in nonmusicians and violinists to understand if there are any changes in the P1 and N1 latencies and absolute amplitudes in the violinists’ groups because of their exposure to violin music. Materials and Methods Twelve participants (6 nonmusicians and 6 violinists) of both genders were included in the study. Pure tone audiometry and distortion product otoacoustic emissions (DPOAEs) were performed on all the participants. cVEMP P1 and N1 latencies and absolute amplitudes were obtained, and overall mean differences were compared within and between groups. Results Pure tone average and DPOAE were within the normal range between and within the groups. Results indicate that P1 and N1 absolute amplitudes and latencies were slightly prolonged in the violinists’ group; however, the mean difference was not statistically significant. Comparison of mean absolute amplitudes and latencies between the ears in the violinists’ group showed longer latencies and greater absolute amplitudes in the left ear of violinists as compared with the right ear. In the study, the violinists’ group consisted of participants who had an average daily exposure of about one-and-a-half hours and had an experience of playing the instrument for more than 5 years. Conclusion cVEMP is useful in detecting early changes in the saccule that may occur due to noise exposure. It can be concluded that, even before a clinically detectable hearing loss or vestibular damage, changes in saccule are observed with the help of cVEMP and should be included in the audiovestibular test for early identification.

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Cochlear Damages Caused by Vibration Exposure

Cited by 8 publications

References 13 publications

Correlation of SNR Value on DPOAE Examination with HSP70 Levels in Blood and HSP70 Expression in Cochlea of Noise Model Rattus norvegicus as an Indicator of Inner Ear Damage

Correlation of SNR Value on DPOAE Examination with HSP70 Levels in Blood and HSP70 Expression in Cochlea of Noise Model Rattus norvegicus as an Indicator of Inner Ear Damage

Anatomy of the rabbit inner ear using computed tomography and magnetic resonance imaging

Comparison of Saccular Function in Nonmusicians and Violinists Using cVEMP: A Pilot Study

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