Cochlear dimensions obtained in hemicochleae of four different strains of mice: CBA/CaJ, 129/CD1, 129/SvEv and C57BL/6J

Keiler, Susan; Richter, Claus Peter

doi:10.1016/s0378-5955(01)00374-4

Cited by 44 publications

(46 citation statements)

References 19 publications

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“…3A). Measurements of basilar membrane width as a function of its length in this cochlea is similar to that previously reported by other investigators (Ehret and Frankenreister, 1977;Burda et al, 1988;Keiler and Richter, 2001) for the mouse cochlea. This graphic method of presenting width change along the length of the basilar membrane is effective but removes an observer from the true geometry of the structure.…”

Section: Methods and Resultssupporting

confidence: 90%

Development of the mouse cochlea database (MCD)

2008

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The Mouse Cochlea Database (MCD) provides an interactive, image database of the mouse cochlea for learning its anatomy and data mining of its resources. The MCD website is hosted on a centrally maintained, high-speed server at the following URL: http://mousecochlea.umn.edu. The MCD contains two types of image resources, serial 2D image stacks and 3D reconstructions of cochlear structures. Complete image stacks of the cochlea from two different mouse strains were obtained using Orthogonal Plane Fluorescence Optical Microscopy (OPFOS). 2D images of the cochlea are presented on the MCD website as: viewable images within a stack, 2D atlas of the cochlea, orthogonal sections, and direct volume renderings combined with isosurface reconstructions. In order to assess cochlear structures quantitatively, "true" cross sections of the scala media along the length of the basilar membrane were generated by virtual resectioning of a cochlea orthogonal to a cochlear structure, such as the centroid of the basilar membrane or the scala media. 3D images are presented on the MCD website as: direct volume renderings, movies, interactive QuickTime VRs, flythrough, and isosurface 3D reconstructions of different cochlear structures. 3D computer models can also be used for solid model fabrication by rapid prototyping and models from different cochleas can be combined to produce an average 3D model. The MCD is the first comprehensive image resource on the mouse cochlea and is a new paradigm for understanding the anatomy of the cochlea, and establishing morphometric parameters of cochlear structures in normal and mutant mice.

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Section: Methods and Resultssupporting

confidence: 90%

Development of the mouse cochlea database (MCD)

2008

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“…The values were 1.69±0.2, 2.55±0.4, and 4.52± 0.5 mm, for the apical (n=11), middle (n=11), and basal (n=11) cut edge, respectively. For graphing reasons, all distances were transformed into distances calculated from the cochlear base, using data of total BM length measurements in CBA/CaJ mice, obtained in previous studies (Keiler and Richter 2001). Thus, stiffness measurements were taken at 4.15, 3.29, and 1.32 mm distances from the cochlear base.…”

Section: Resultsmentioning

confidence: 99%

Basilar Membrane and Tectorial Membrane Stiffness in the CBA/CaJ Mouse

Teudt

Richter

2014

JARO

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The mouse has become an important animal model in understanding cochlear function. Structures, such as the tectorial membrane or hair cells, have been changed by gene manipulation, and the resulting effect on cochlear function has been studied. To contrast those findings, physical properties of the basilar membrane (BM) and tectorial membrane (TM) in mice without gene mutation are of great importance. Using the hemicochlea of CBA/CaJ mice, we have demonstrated that tectorial membrane (TM) and basilar membrane (BM) revealed a stiffness gradient along the cochlea. While a simple spring mass resonator predicts the change in the characteristic frequency of the BM, the spring mass model does not predict the frequency change along the TM. Plateau stiffness values of the TM were 0.6±0.5, 0.2± 0.1, and 0.09±0.09 N/m for the basal, middle, and upper turns, respectively. The BM plateau stiffness values were 3.7±2.2, 1.2±1.2, and 0.5±0.5 N/m for the basal, middle, and upper turns, respectively. Estimations of the TM Young's modulus (in kPa) revealed 24.3±25.2 for the basal turns, 5.1±4.5 for the middle turns, and 1.9±1.6 for the apical turns. Young's modulus determined at the BM pectinate zone was 76.8±72, 23.9±30.6, and 9.4±6.2 kPa for the basal, middle, and apical turns, respectively. The reported stiffness values of the CBA/CaJ mouse TM and BM provide basic data for the physical properties of its organ of Corti.

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“…The mechanism underlying the cochlear frequencyposition mapping characteristic is believed to be similar in (Wever, 1949), cat (Cabezudo, 1978), guinea pig (Fern andez, 1952), chinchilla (Dallos, 1970), and mouse (Keiler and Richter, 2001). All variables are plotted against a length scale normalized by the physical length of the cochleae.…”

Section: Distribution Of the Characteristic Frequencymentioning

confidence: 99%

“…All variables are plotted against a length scale normalized by the physical length of the cochleae. Cabezudo (1978), (b) Dallos (1970), (c) Wever (1949), (d) Fern andez (1952, (e) Greenwood (1990), (f) Keiler and Richter (2001), and (g) Liberman (1982 (Robles and Ruggero, 2001). There is, however, a wide range of physical dimensions of the cochlea in different mammals, resulting in difference in perceptible hearing frequency range.…”

Section: Distribution Of the Characteristic Frequencymentioning

confidence: 99%

A linearly tapered box model of the cochlea

Sun

Elliott

2017

The Journal of the Acoustical Society of America

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A box shape with constant area is often used to represent the complex geometry in the cochlea, although variation of the fluid chambers areas is known to be more complicated. This variation is accounted for here by an “effective area,” given by the harmonic mean of upper and lower chamber area from previous measurements. The square root of this effective area varies linearly along the cochleae in the investigated mammalian species. This suggests the use of a linearly tapered box model in which the fluid chamber width and height are equal, but decrease linearly along its length. The basilar membrane (BM) width is assumed to increase linearly along the model. An analytic form of the far-field fluid pressure difference due to BM motion is derived for this tapered model. The distributions of the passive BM response are calculated using both the tapered and uniform models and compared with human and mouse measurements. The discrepancy between the models is frequency-dependent and becomes small at low frequencies. The tapered model developed here shows a reasonable fit to experimental measurements, when the cochleae are cadaver or driven at high sound pressure level, and provides a convenient way to incorporate cochlear geometrical variations.

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Cochlear dimensions obtained in hemicochleae of four different strains of mice: CBA/CaJ, 129/CD1, 129/SvEv and C57BL/6J

Cited by 44 publications

References 19 publications

Development of the mouse cochlea database (MCD)

Development of the mouse cochlea database (MCD)

Basilar Membrane and Tectorial Membrane Stiffness in the CBA/CaJ Mouse

A linearly tapered box model of the cochlea

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