Cochlear function after selective inner hair cell degeneration induced by carboplatin

Takeno, Sachio; Harrison, Robert V.; Ibrahim, Danyal; Wake, M.; Mount, Richard J.

doi:10.1016/0378-5955(94)90060-4

Cited by 94 publications

(60 citation statements)

References 33 publications

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“…In most cases of sensorineural hearing loss, whether due to noise (Liberman and Kiang 1978), ototoxic drugs (Huizing and de Groot 1987), or genetic anomalies, the loss of inner hair cells is associated with significant, or complete, loss of outer hair cells; in other words, outer hair cells tend to be the most vulnerable elements in the inner ear. In animal studies, one exception to this rule is the selective inner hair cell loss seen in the chinchilla after systemic administration of carboplatin, a chemotherapeutic drug (Takeno et al 1994). In other species (e.g., guinea pig), carboplatin causes loss of both inner and outer hair cells (Taudy et al 1992).…”

Section: Figmentioning

confidence: 99%

Deletion of SLC19A2, the High Affinity Thiamine Transporter, Causes Selective Inner Hair Cell Loss and an Auditory Neuropathy Phenotype

Liberman

Tartaglini

Fleming

et al. 2006

JARO

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Mutations in the gene coding for the high-affinity thiamine transporter Slc19a2 underlie the clinical syndrome known as thiamine-responsive megaloblastic anemia (TRMA) characterized by anemia, diabetes, and sensorineural hearing loss. To create a mouse model of this disease, a mutant line was created with targeted disruption of the gene. Cochlear function is normal in these mutants when maintained on a high-thiamine diet. When challenged with a low-thiamine diet, Slc19a2-null mice showed 40-60 dB threshold elevations by auditory brainstem response (ABR), but only 10-20 dB elevation by otoacoustic emission (OAE) measures. Wild-type mice retain normal hearing on either diet. Cochlear histological analysis showed a pattern uncommon for sensorineural hearing loss: selective loss of inner hair cells after 1-2 weeks on low thiamine and significantly greater inner than outer hair cell loss after longer low-thiamine challenges. Such a pattern is consistent with the observed discrepancy between ABR and OAE threshold shifts. The possible role of thiamine transport in other reported cases of selective inner hair cell loss is considered.

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Section: Figmentioning

confidence: 99%

Deletion of SLC19A2, the High Affinity Thiamine Transporter, Causes Selective Inner Hair Cell Loss and an Auditory Neuropathy Phenotype

Liberman

Tartaglini

Fleming

et al. 2006

JARO

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“…Alternatively, hearing loss in DFNA2 may result from a defective afferent signal transmission, from either a defective central auditory pathway whose neurons are known to express KCNQ4 (Kharkovets et al, 2000) or functional defects in inner hair cells (IHCs) (Takeno et al, 1994;Wang et al, 1997). Information on expression of KCNQ4 in IHCs, however, has been contradictory.…”

Section: Introductionmentioning

confidence: 97%

Resting Potential and Submembrane Calcium Concentration of Inner Hair Cells in the Isolated Mouse Cochlea Are Set by KCNQ-Type Potassium Channels

Knipper²,

et al. 2003

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“…*Corresponding author Henry C. Ou, University of Washington, VMB Hearing Research Center,Box 357923,Seattle,Telephone: (206) Fax: (206) Email: henryou@u.washington.edu.Cisplatin is known to cause hair cell death, with the outer hair cells showing greater susceptibility than inner hair cells;the cisplatin derivative carboplatin is thought to cause primarily inner hair cell death in some species (Takeno et al, 1994;Wake et al, 1993). Cisplatin is also thought to have damaging effects on the stria vascularis, spiral ganglion cells, and possibly the supporting cells of the inner ear (Saito and Aran 1994;Zheng et al, 1995;Campbell et al, 1999;Cardinaal et al, 2000a;Ramirez-Camacho et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line

Ou¹,

Raible²,

Rubel³

2007

Hearing Research

141

151

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We have used time-lapse imaging to study cisplatin-induced hair cell death in lateral line neuromasts of zebrafish larvae in vivo. We found that cisplatin-induced hair cell death occurred much more slowly than had been shown to occur in aminoglycoside-induced hair cell death. By prelabeling hair cells with FM1-43FX, and assessing hair cell damage, it was established that cisplatin causes hair cell loss in the lateral line in a dose-dependent fashion. The kinetics of hair cell loss during exposure to different concentrations of cisplatin was also assessed and it was found that the onset of hair cell loss correlated with the accumulated dose of cisplatin. These data demonstrate the feasibility and repeatability of cisplatin damage protocols in the zebrafish lateral line and set the stage for future evaluations of modulation of cisplatin-induced hair cell death.

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Cochlear function after selective inner hair cell degeneration induced by carboplatin

Cited by 94 publications

References 33 publications

Deletion of SLC19A2, the High Affinity Thiamine Transporter, Causes Selective Inner Hair Cell Loss and an Auditory Neuropathy Phenotype

Deletion of SLC19A2, the High Affinity Thiamine Transporter, Causes Selective Inner Hair Cell Loss and an Auditory Neuropathy Phenotype

Resting Potential and Submembrane Calcium Concentration of Inner Hair Cells in the Isolated Mouse Cochlea Are Set by KCNQ-Type Potassium Channels

Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line

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