Cochlear function tests in estimation of speech dynamic range

Han, Jung Ju; Park, So Young; Park, Shi Nae; Na, Mi Sun; Lee, Philip; Han, Jae Sang

doi:10.1080/00016489.2016.1175664

Cited by 3 publications

(3 citation statements)

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“…In addition, a reduced dynamic range is responsible for limited maximum power output in hearing amplifica-DOI: 10.1159/000489813 tion devices [Han et al, 2016]. In our patients, the dynamic range after stapes surgery was large because of improvements in hearing thresholds and the discomfort level remaining within the normal range.…”

Section: Discussionmentioning

confidence: 85%

Stapes Surgery for Otosclerosis in Patients Presenting with Mixed Hearing Loss

2018

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Objectives: To evaluate the efficacy of stapes surgery in patients presenting with a preoperative mixed hearing loss (bone conduction thresholds ≥40 dB; 40 < air conduction thresholds (AC) < 85 dB). Patients and Methods: A total of 30 patients (32 ears) with mixed hearing loss who underwent primary stapedotomy were evaluated. Audiometric parameters were assessed before and after surgery. Contralateral thresholds were also reported. The need for a hearing aid (HA) after surgery and its impact on quality of life were also measured. Results: AC and word recognition at 40, 55 and 70 dB were significantly improved after stapes surgery. Only 16.6% of the patients needed an HA after surgery and reported being satisfied with the aid. Conclusion: Stapes surgery improved auditory function in patients with mixed hearing loss, allowing most patients to delay the need for an HA without worsening their quality of life.

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Section: Discussionmentioning

confidence: 85%

Stapes Surgery for Otosclerosis in Patients Presenting with Mixed Hearing Loss

2018

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“…Recruitment leads to an enhanced perception and often distortion of loud sounds in an ear with decreased hearing. [9,10] Short increment sensitivity index is one of the most significant tests to evaluate recruitment presence. The diagnosis of vestibular migraine is mainly based on the patient history and there are no established useful audiological parameters or biomarkers to support the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of phonophobia with audiological tests in vestibular migraine patients

Göde¹

2017

Kulak Burun Bogaz Ihtis Derg

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Objectives: This study aims to review the diagnostic value of loudness discomfort level (LDL) and short increment sensitivity index (SISI) measurements in patients with vestibular migraine. Patients and Methods:The study included 20 vestibular migraine patients (group 1; 5 males, 15 females; mean age 42.1 years; range 16 to 60 years) and 20 healthy controls (group 2; 6 males, 14 females; mean age 20.3 years; range 18 to 30 years). Pure tone audiometry, SISI, tympanometry, and LDL test were performed. Results:Median LDL scores in groups 1 and 2 were 99.50 dB (interquartile range: 19.5) and 105 dB (interquartile range: 6), respectively. LDL scores were significantly lower in group 1 (p<0.05). According to the receiver operating characteristic analysis of LDL measurements, the area under curve was 0.76 (p<0.05) when vestibular migraine was the selection criterion. When 103.5 dB was taken as the cut-off point, the sensitivity of LDL test was 75% and specificity was 82%. There was no significant relationship between the SISI scores and phonophobia (p>0.05). Conclusion:To our knowledge, this is the first study to show the potential diagnostic value of LDL as an audiological test in vestibular migraine. Further studies are warranted to elucidate the diagnostic value of LDL in the differential diagnosis of episodic vertigo.Keywords: Loudness discomfort level; phonophobia; short increment sensitivity index; vestibular migraine. ÖZAmaç: Bu çalışmada vestibüler migren hastalarında rahatsız edici ses düzeyi (LDL) ve short increment sensitivity index (SISI) ölçümlerinin tanısal değeri incelendi. Bulgular: Grup 1 ve 2'de medyan LDL skorları sırasıyla 99.50 dB (çeyrekler açıklığı: 19.5) ve 105 dB (çeyrekler açıklığı: 6) idi. LDL skorları grup 1'de anlamlı olarak daha düşük idi (p<0.05). Vestibüler migren seçim ölçütü olduğunda, LDL ölçümlerinin alıcı işletim karakteristiği analizine göre eğri altında kalan alan 0.76 (p<0.05) idi. Eşik noktası olarak 103.5 dB belirlendiğinde, LDL testinin duyarlılığı %75, özgüllüğü ise %82 idi. SISI skorları ve fonofobi arasında anlamlı ilişki yoktu (p>0.05).Sonuç: Bildiğimiz kadarıyla, LDL'nin vestibüler migrende bir odyolojik test olarak potansiyel tanısal değerini gösteren ilk çalışma budur. LDL'nin epizodik vertigonun ayırıcı tanısındaki tanısal değerinin aydınlatılması için ileri çalışmalara gereksinim vardır.Anahtar Sözcükler: Rahatsız edici ses düzeyi; fonofobi; short increment sensitivity index; vestibüler migren.

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“…Artificial receptors can be produced on the cancer cell surface by using cancer cell characteristics and the tumor microenvironment (TME). Polydopamine (PDA) with low toxicity, excellent biocompatibility, and ultrastability (Liu et al, 2013;Han et al, 2016;Poinard et al, 2018) is widely known for its specific reactivity to the amino groups through Michael addition and Schiff base reaction (Lee et al, 2009;Liu et al, 2014;Li et al, 2017;Sileika et al, 2011). Thus, PDA with amino groups can be considered as a safe and efficient artificial receptor for anticancer drugs in the TME.…”

Section: Introductionmentioning

confidence: 99%

Precise Deposition of Polydopamine on Cancer Cell Membrane as Artificial Receptor for Targeted Drug Delivery

Yazd¹,

Yang²,

Li³

et al. 2020

iScience

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Summary Compared with conventional chemotherapy and radiotherapy, targeted molecular therapy, e.g., antibody-drug conjugates or aptamer-drug conjugates, can specifically identify overexpressed natural receptors on the cancer cell, perform targeted release of anticancer drugs, and achieve targeted killing of tumor cells. However, many natural receptors are also expressed on non-cancer cells, thereby diverting the targeting molecules to healthy cells. By generating artificial cell surface receptors specific to diseased cells, aptamer-drug conjugates can identify these artificial receptors, improve therapeutic efficacy, and decrease the minimum effective dosage. In this study, we use high K + and high H 2 O 2 of the tumor microenvironment (TME) to produce polydopamine only on living cancer cell membrane. Owing to the significant reactivity of polydopamine with amino groups, e.g., the amino group of proteins, polydopamine can deposit on tumor cells and act as “artificial receptors” for targeted delivery of anticancer drugs with amino groups, in other words, amino-containing drugs and protein drugs.

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Cochlear function tests in estimation of speech dynamic range

Cited by 3 publications

References 15 publications

Stapes Surgery for Otosclerosis in Patients Presenting with Mixed Hearing Loss

Stapes Surgery for Otosclerosis in Patients Presenting with Mixed Hearing Loss

Evaluation of phonophobia with audiological tests in vestibular migraine patients

Precise Deposition of Polydopamine on Cancer Cell Membrane as Artificial Receptor for Targeted Drug Delivery

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