Cochlear Implantation in Children With Congenital Cytomegalovirus Infection

Yoshida, Haruo; Kanda, Yukihiko; Takahashi, Haruo; Miyamoto, Ikue; Yamamoto, Tomomi M.; Kumagami, Hidetaka

doi:10.1097/mao.0b013e3181b1212e

Cited by 41 publications

(47 citation statements)

References 26 publications

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“…There are no publications to our knowledge that report the incidence of CMV infections in SSD patients. In children with bilateral congenital deafness, CMV infection is reported to be a common cause by Deltenre and Van Maldergem [2013] and Yoshida et al [2009]. Intrauterine CMV infection is estimated to affect approximately 0.5-2.5% of all live births [Hagay et al, 1996].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, another reason for the poor audiological results of our congenitally deaf children might be the congenital CMV infection, since other authors, e.g. Yoshida et al [2009], reported inferior outcomes of CI surgery in bilaterally deaf children due to congenital CMV infection compared to children with non-CMV-related deafness. In agreement, Viccaro et al [2012] described long-term results for CI surgery in 6 children with congenital CMV-related deafness; only 2 of them showed appropriate use of grammar and syntax, the other 4 used only single words.…”

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confidence: 92%

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Cochlear Implantation in Children with Single-Sided Deafness: Does Aetiology and Duration of Deafness Matter?

et al. 2015

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For adult patients with single-sided deafness (SSD), treatment with a cochlear implant (CI) is well established as an acceptable and beneficial hearing rehabilitation method administered routinely in clinical practice. In contrast, for children with SSD, CI has been applied less often to date, with the rationale to decide either on a case-by-case basis or under the realm of clinical research. The aim of our clinical study was to evaluate the longitudinal benefits of CI for a group of children diagnosed with SSD and to compare their outcomes with respect to patient characteristics. Evaluating a pool of paediatric SSD patients presenting for possible CI surgery revealed that the primary aetiology of deafness was congenital cochlear nerve deficiency. A subgroup of children meeting the CI candidacy criteria for the affected ear (the majority with acquired hearing loss) were enrolled in the study. Preliminary group results suggest substantial improvements in speech comprehension in noise and in the ability to localise sound, which was demonstrated through objective and subjective assessments after CI treatment for the group, with results varying from patient to patient. Our study shows a trend towards superior outcomes for children with acquired hearing loss and a shorter duration of hearing loss compared to congenitally deafened children who had a longer duration of SSD. This indicates an interactive influence of the age at onset, aetiology and duration of deafness upon the restoration of binaural integration and the overall benefits of sound stimulation to two ears after CI treatment. Continued longitudinal investigation of these children and further studies in larger groups may provide more guidance on the optimal timing of treatment for paediatric patients with acquired and congenital SSD.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 92%

Cochlear Implantation in Children with Single-Sided Deafness: Does Aetiology and Duration of Deafness Matter?

et al. 2015

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“…This outcome might be related to central nervous system involvement since no association between duration of deafness, age at implant and speech outcomes was evident in our study group. Yoshida et al [2009] claim that CMV children without cognitive delay manage to bridge the gap with their non-CMV peers over a 1-year follow-up. However, in our long-term study we showed how both symptomatic and asymptomatic CMV implantees still underperformed both in speech perception and language development compared to their non-CMV peers.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it is also important to remember that CMV children have poor attention control and are considered more susceptible to later complications such as learning difficulties. Hence, careful observation is required on clinical course after cochlear implantation [Yoshida et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Follow-Up of Implanted Children with Cytomegalovirus-Related Deafness

Viccaro¹,

Filipo²,

Bosco³

et al. 2012

Audiol Neurotol

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Objective: To evaluate, with a long-term follow-up, the speech perception and language development in children with cytomegalovirus (CMV)-related deafness after cochlear implantation. Study Design: A retrospective study on CMV-related profound deafness and cochlear implantation was performed from 1995 to 2010. Six children with an average follow-up of 10 years were included in this research. Medical history, imaging, cognitive delay, speech perception and production data were reviewed. Results: Two of the 6 patients developed a functional language with the use of phrases and word sequences based on morphological and syntactic rules; the others demonstrated the development of a preverbal or transitional language with the use of single words only. Conclusion: Patients with CMV-related deafness benefit from cochlear implantation; however, the expectations of the parents must be evaluated in a series of counseling efforts prior to the surgery.

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“…One year after CI, language perception and production showed similarly good progress for both the CMV-and non-CMV-related hearing loss groups. (Yoshida et al 2009) Prompt detection and management of late-onset hearing loss in early childhood have also been shown to improve language development, including a benefit from early fitting with cochlear implants. (Stacey et al 2006;Nicholas and Geers 2007) For example, one study demonstrated that being implanted within 12 months of hearing loss onset was associated with significantly better language outcomes.…”

Section: Newborn Screening Criteria and Congenital CMVmentioning

confidence: 99%

Public health and laboratory considerations regarding newborn screening for congenital cytomegalovirus

Dollard

Schleiss

Grosse

2010

J of Inher Metab Disea

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Congenital cytomegalovirus (CMV) infection is the most common infection in newborns worldwide and causes hearing loss and other neurological disability in 15-20% of infected infants. Only about half of the hearing loss resulting from congenital CMV infection is currently detected by universal newborn hearing screening because of late-onset hearing loss. Thus, much of the hearing loss and the majority of other CMV-associated disabilities remain undetected for years after birth and are never connected to CMV infection. Congenital CMV may be appropriate to include in national newborn screening (NBS) programs because it is more common than other disorders tested for by NBS programs and is a major cause of disability. Significant obstacles to the implementation of screening for congenital CMV include the lack of a standardized, high-throughput screening test and a protocol for follow-up of CMV-infected children. Nonetheless, screening newborns for congenital CMV infection merits further consideration.

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Cochlear Implantation in Children With Congenital Cytomegalovirus Infection

Abstract: Long-term results of the language perception and production after CI was satisfactory in Japanese children with congenital CMV-related deafness compared with in subjects deafened by other causes. CMV alone, as a cause of deafness, is not likely a contraindication for CI.

Cited by 41 publications

References 26 publications

Cochlear Implantation in Children with Single-Sided Deafness: Does Aetiology and Duration of Deafness Matter?

Cochlear Implantation in Children with Single-Sided Deafness: Does Aetiology and Duration of Deafness Matter?

Long-Term Follow-Up of Implanted Children with Cytomegalovirus-Related Deafness

Public health and laboratory considerations regarding newborn screening for congenital cytomegalovirus

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