Cochlear Potentials in Clinical Audiology

Ferraro, John A.; Krishnan, Geetha

doi:10.1159/000259251

Cited by 33 publications

(28 citation statements)

References 22 publications

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“…This increase of the SP in patients with early MD, along with studies showing a positive temporal correlation of enhanced SP and symptom reporting and inally a decrease of the SP with the use of hyperosmolar agents [35], all strengthen the premise of hydrops being responsible for symptom constellation.…”

Section: The Evidence-based Indings Between Hydrops and Symptomssupporting

confidence: 55%

Pathophysiology of Meniere's Disease

Mirza¹,

Gokhale²

2017

Up to Date on Meniere's Disease

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Meniere's disease, with its characteristic symptom triad of vertigo, balance and hearing disorders has yet to have its pathophysiology outlined conclusively. Any theory must elucidate all aspects of the natural progression, including vestibular and auditory symptoms. While the central dogma revolves around endolymphatic hydrops, this theory is not without laws, such as its inability to explain all the physiological changes seen in patients, or the often absence of symptoms. While several degenerative changes are observed in temporal bone histopathology, they do not necessarily explain the sequence of events in the development and progress of the disease. This chapter explores the pathophysiology of the disease, focusing on the hydrops theory, while presenting evidence for and against it. Various changes in the inner ear physiology such as pressure changes, ionic disequilibrium, endocochlear potentials; in human and animal models are described. Alternative explanations for symptoms are discussed. This chapter touches briely upon etiology associated with Meniere's (and hydrops), and aims to assist a deeper understanding of the relationship of the process to clinical and experimental indings. A clear understanding of the process guides not only the clinical management to improve quality of life but also the direction of future research endeavors.

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Section: The Evidence-based Indings Between Hydrops and Symptomssupporting

confidence: 55%

Pathophysiology of Meniere's Disease

Mirza¹,

Gokhale²

2017

Up to Date on Meniere's Disease

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“…The analysis of the variable area was included in our study since it also represents a good parameter of interpretation of nerve conduction studies. The calculation of the SP/AP area ratio, described in some studies 11,12 and used in the present study, stands out as a very sensitive test to assess cochlear response to hearing stimulus in Ménière's disease, as well as in situations in which the cochlea is at risk due to surgical injury 13 . Since SP/AP area ratio is the integral of a function of the combination between amplitude and duration of action potential, Riemann integral reflects the number and synchronism of activated nerve fibers.…”

Section: Discussionmentioning

confidence: 99%

Avaliação dos potenciais evocados cocleares após lesão do utrículo por eletrocauterização

Maia¹,

Dolganov²,

Lavinsky³

2012

Braz. j. otorhinolaryngol.

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Ut riculostomy is a new surgical alternative for Ménière's disease. The basis of this procedure is that the outcome of an electrocautery-induced utricular trauma does not affect cochlear function. However, a demonstration of the hypothesis that this approach to the utricle would preserve hearing is still pending.Objective: To determine whether any changes would occur in the electrical potentials evoked in the cochlea and auditory nerve before, during, and 1 month after a surgical procedure in the utricule in an animal model. Materials and Methods:An experimental study. Eight sheep underwent electrocautery-induced utricular trauma, and their cochlear function was assessed by electrocochleography -recording of electrical evoked potentials, in the preoperative, immediate postoperative and medium-term postoperative periods. The results were analyzed statistically.Results: There were no statistically significant variations in amplitude (p = 0.099) and latency (p = 0.591) before and 1 month after the surgical procedure. There was a statistically significant change in the summation of the potential/action potential area ratio (p = 0.0122), a calculated loss of 11.8 dB. Conclusion:The intervention performed in this study enabled us to conclude that, taking into account the impaired electrophysiological responses observed during and 1 month after the surgical procedure, hearing was preserved in the operated sheep. ORIGINAL ARTICLEBraz J Otorhinolaryngol. 2012;78(2):52-8.

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“…Electrocochleography (ECoG), which had a significant clinical impact in the diagnosis and monitoring of Ménière's disease, [27][28][29] and which objectively assesses cochlear potentials, is the indicated clinical procedure to analyze CMs. 30,31 The recent development of various non-invasive electrodes have reawakened interest in the clinical use of ECoG.…”

Section: Introductionmentioning

confidence: 99%

“…30,31 The recent development of various non-invasive electrodes have reawakened interest in the clinical use of ECoG. 27,32 Although transtympanic electrocochleography (TT-ECoG) yields recordings with higher amplitudes and lower test-retest variability, it has the disadvantage of being an invasive procedure. Extratympanic electrocochleography (ET-ECoG), therefore, is clinically more useful in this context, supporting an audiological diagnosis and increasing knowledge about cochlear function in AN/AD.…”

Section: Introductionmentioning

confidence: 99%

Eletrococleografia extratimpânica na neuropatia/dessincronia auditiva

Anastásio

Alvarenga

Filho

2008

Rev. Bras. Otorrinolaringol.

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The brainstem auditory evoked potential (BAEP) is being extensively used as a method for the evaluation of cochlear function in individuals with diagnosis of auditory neuropathy/auditory dyssynchrony (AN/AD). In the absence of otoacoustic emissions, many cases of AN/AD have been diagnosed by the presence of CM identified in the BAEP. Aim: to demonstrate the clinical applicability of extratympanic electrocochleography (ET-Ecochg) in the differential diagnosis of AN/AD compared to the BAEP. Method: a 4-year-old child with a diagnosis of AN/AD seen at the Audiological Research Center was submitted to ET-Ecochg with a 2000 Hz tone burst in rarefaction and condensation polarities. Results: the ET-Ecochg exam was illustrated. Using an appropriate protocol, it was possible to demonstrate CM and to confirm it in the Ecochg, with a recording quality superior to that obtained in the BAEP. Conclusion: ET-Ecochg permitted a more detailed analysis of CM compared to the BAEP, thus showing clinical applicability for the investigation of cochlear function in AN/AD.

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Cochlear Potentials in Clinical Audiology

Cited by 33 publications

References 22 publications

Pathophysiology of Meniere's Disease

Pathophysiology of Meniere's Disease

Avaliação dos potenciais evocados cocleares após lesão do utrículo por eletrocauterização

Eletrococleografia extratimpânica na neuropatia/dessincronia auditiva

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