Cochleotopic organization of primary auditory cortex in the cat

Merzenich, Michael M.; Knight, Paul L.; Roth, Gerhard

doi:10.1016/0006-8993(73)90101-7

Cited by 79 publications

(33 citation statements)

References 13 publications

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“…Neuroimaging techniques allow for the non‐invasive investigation of the functional organization of the auditory cortex (AC) in the human brain: In agreement with previous animal studies (e.g., cats and primates; Merzenich and Brugge, 1973; Merzenich et al, 1973), functional magnetic resonance imaging (fMRI) studies have found a tonotopic organization of the human early AC (Da Costa et al, 2011; Formisano et al, 2003; Humphries et al, 2010; Langers and van Dijk, 2012; Talavage et al, 2004; Woods et al, 2010). Human early AC tonotopy has been consistently described as two frequency gradients composing a high‐low‐high preferred frequency pattern located in and around the Heschl's gyrus (HG).…”

Section: Introductionsupporting

confidence: 81%

Tonotopic maps in human auditory cortex using arterial spin labeling

Gardumi

Ivanov

Havlíček

et al. 2016

Human Brain Mapping

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A tonotopic organization of the human auditory cortex (AC) has been reliably found by neuroimaging studies. However, a full characterization and parcellation of the AC is still lacking. In this study, we employed pseudo‐continuous arterial spin labeling (pCASL) to map tonotopy and voice selective regions using, for the first time, cerebral blood flow (CBF). We demonstrated the feasibility of CBF‐based tonotopy and found a good agreement with BOLD signal‐based tonotopy, despite the lower contrast‐to‐noise ratio of CBF. Quantitative perfusion mapping of baseline CBF showed a region of high perfusion centered on Heschl's gyrus and corresponding to the main high‐low‐high frequency gradients, co‐located to the presumed primary auditory core and suggesting baseline CBF as a novel marker for AC parcellation. Furthermore, susceptibility weighted imaging was employed to investigate the tissue specificity of CBF and BOLD signal and the possible venous bias of BOLD‐based tonotopy. For BOLD only active voxels, we found a higher percentage of vein contamination than for CBF only active voxels. Taken together, we demonstrated that both baseline and stimulus‐induced CBF is an alternative fMRI approach to the standard BOLD signal to study auditory processing and delineate the functional organization of the auditory cortex. Hum Brain Mapp 38:1140–1154, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Introductionsupporting

confidence: 81%

Tonotopic maps in human auditory cortex using arterial spin labeling

Gardumi

Ivanov

Havlíček

et al. 2016

Human Brain Mapping

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“…This position was apparently validated by subsequent expected findings of highly consistent evoked responses in these cortical fields (e.g. [68]). The combination of common sense, venerable belief and apparent scientific validation is very powerful.…”

Section: Introductionsupporting

confidence: 62%

Amygdala Strengthening of Cortical Memory Representations

Chavez¹,

McGaugh²,

Weinberger³

2012

The Amygdala - A Discrete Multitasking Manager

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“…2A). The CF smoothly increases along the anteroposterior axis up to the anterior auditory field (Merzenich et al, 1973). In contrast, group 1 cats showed a modified tonotopic organization (Fig.…”

Section: Cortical Tonotopic Mapsmentioning

confidence: 93%

Enriched Acoustic Environment after Noise Trauma Reduces Hearing Loss and Prevents Cortical Map Reorganization

Noreña¹,

Eggermont²

2005

J. Neurosci.

297

188

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Exposure to sound of sufficient duration and level causes permanent damage to the peripheral auditory system, which results in the reorganization of the cortical tonotopic map. The changes are such that neurons with pre-exposure tuning to frequencies in the hearing loss range now become tuned to frequencies near the near-normal lower boundary of the hearing loss range, which thus becomes over represented. However, cats exposed to a traumatizing noise and immediately thereafter placed for a few weeks in an enriched acoustic environment presented a much-restricted hearing loss compared with similarly exposed cats that were placed for the same time in a quiet environment. The enriched environment spectrally matched the expected hearing loss range and was ϳ40 dB above the level of the expected hearing loss. The hearing loss in the quiet environment-reared cats ranged from 6 to 32 kHz with the largest loss (on average, 40 dB) ranging from 24 to 32 kHz. In contrast, the hearing loss in the enriched-environment cats was restricted to 6 -8 kHz at a level of, on average, 35 dB and with 16 -32 kHz having normal thresholds. Despite the remaining hearing loss for the enriched-environment cats in the 6 -8 kHz range, plastic tonotopic map changes in primary auditory cortex could no longer be demonstrated, suggesting that the enriched acoustic environment prevents this reorganization. This finding has implications for the treatment of hearing disorders, such as tinnitus, that have been linked to cortical tonotopic map reorganization.

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Cochleotopic organization of primary auditory cortex in the cat

Cited by 79 publications

References 13 publications

Tonotopic maps in human auditory cortex using arterial spin labeling

Tonotopic maps in human auditory cortex using arterial spin labeling

Amygdala Strengthening of Cortical Memory Representations

Enriched Acoustic Environment after Noise Trauma Reduces Hearing Loss and Prevents Cortical Map Reorganization

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