Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine

Mailafiya, Maryam Muhammad; Abubakar, Kabeer; Danmaigoro, Abubakar; Chiroma, Samaila Musa; Rahim, Ezamin Abdul; Moklas, Mohamad Aris Mohd; Zakaria, Zuki Abu Bakar

doi:10.3390/app9142897

Cited by 48 publications

(17 citation statements)

References 138 publications

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“…Other osteochondral scaffold designs have incorporated specific ceramic formulations such as aragonite and wollastonite as minerals for the bone layer. Aragonite is a calcium carbonate material derived from cockle shell [ 109 ], while wollastonite is a calcium silicate mineral [ 110 ], both of which are bioactive and help promote subchondral bone repair. An aragonite scaffold combined with hyaluronate as the cartilage phase completely regenerated an osteochondral defect in 6 of 7 animals at 12 months after implantation in a goat model, exhibiting formation of hyaline cartilage and subchondral bone with strong integration into adjacent native tissues [ 74 ].…”

Section: Multiphasic Scaffold Biomaterialsmentioning

confidence: 99%

Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies

Chen

Pye

et al. 2023

Bioactive Materials

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Section: Multiphasic Scaffold Biomaterialsmentioning

confidence: 99%

Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies

Chen

Pye

et al. 2023

Bioactive Materials

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“…Remarkable strength, unique electrical properties, functionalization-enhanced solubility, penetration to cell cytoplasm and to the nucleus, as a carrier for gene delivery [ 27 , 28 ]…”

Section: Figurementioning

confidence: 99%

The Nanosystems Involved in Treating Lung Cancer

Crintea

Duţu

Samaşcă

et al. 2021

Life

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Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest. Because of the complex signaling pathways involved in developing different types of cancer, the need to discover new methods for prevention and detection is crucial in producing gene delivery materials that exhibit the desired roles. Scientists have confirmed that nanotechnology-based procedures are more effective than conventional chemotherapy or radiotherapy, with minor side effects. Several nanoparticles, nanomaterials, and nanosystems have been studied, including liposomes, dendrimers, polymers, micelles, inorganic nanoparticles, such as gold nanoparticles or carbon nanotubes, and even siRNA delivery systems. The cytotoxicity of such nanosystems is a debatable concern, and nanotechnology-based delivery systems must be improved to increase the bioavailability, biocompatibility, and safety profiles, since these nanosystems boast a remarkable potential in many biomedical applications, including anti-tumor activity or gene therapy. In this review, the nanosystems involved in treating lung cancer and its associated challenges are discussed.

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“…These shells are discarded in large amounts in the food industry. Cockle shells have a high calcium carbonate content [ 9 ]. These shells are abundantly available at a minimal cost, and in vitro studies have demonstrated that the calcium carbonate derived from cockle shells is biocompatible [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the chemical, physical, and biological properties of a newly developed bioceramic cement derived from cockle shells: an in vitro study

Wannakajeepiboon,

Sathorn,

Kornsuthisopon

et al. 2023

BMC Oral Health

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Background Tricalcium silicate is the main component of commercial bioceramic cements that are widely used in endodontic treatment. Calcium carbonate, which is manufactured from limestone, is one of the substrates of tricalcium silicate. To avoid the environmental impact of mining, calcium carbonate can be obtained from biological sources, such as shelled mollusks, one of which is cockle shell. The aim of this study was to evaluate and compare the chemical, physical, and biological properties of a newly developed bioceramic cement derived from cockle shell (BioCement) with those of a commercial tricalcium silicate cement (Biodentine). Methods BioCement was prepared from cockle shells and rice husk ash and its chemical composition was determined by X-ray diffraction and X-ray fluorescence spectroscopy. The physical properties were evaluated following the International Organization for Standardization (ISO) 9917-1;2007 and 6876;2012. The pH was tested after 3 h to 8 weeks. The biological properties were assessed using extraction medium from BioCement and Biodentine on human dental pulp cells (hDPCs) in vitro. The 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5[(phenylamino)carbonyl]-2 H-tetrazolium hydroxide assay was used to evaluate cell cytotoxicity following ISO 10993-5;2009. Cell migration was examined using a wound healing assay. Alizarin red staining was performed to detect osteogenic differentiation. The data were tested for a normal distribution. Once confirmed, the physical properties and pH data were analyzed using the independent t-test, and the biological property data were analyzed using one way ANOVA and Tukey’s multiple comparisons test at a 5% significance level. Results The main components of BioCement and Biodentine were calcium and silicon. BioCement’s and Biodentine’s setting time and compressive strength were not different. The radiopacity of BioCement and Biodentine was 5.00 and 3.92 mmAl, respectively (p < 0.05). BioCement’s solubility was significantly higher than Biodentine. Both materials exhibited alkalinity (pH ranged from 9 to 12) and demonstrated > 90% cell viability with cell proliferation. The highest mineralization was found in the BioCement group at 7 days (p < 0.05). Conclusions BioCement exhibited acceptable chemical and physical properties and was biocompatible to human dental pulp cells. BioCement promotes pulp cell migration and osteogenic differentiation.

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Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine

Cited by 48 publications

References 138 publications

Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies

Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies

The Nanosystems Involved in Treating Lung Cancer

Evaluation of the chemical, physical, and biological properties of a newly developed bioceramic cement derived from cockle shells: an in vitro study

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