Cockroach allergen (Bla g 1) in school dust

Sarpong, Sampson B.; Wood, Robert A.; Karrison, Theodore; Eggleston, Peyton A.

doi:10.1016/s0091-6749(97)70074-5

Cited by 62 publications

(46 citation statements)

References 17 publications

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“…In inner-city schools in Baltimore, MD, 69% of the dust samples were shown to contain detectable cockroach allergen Bla g 1 [31]. Higher levels were reported in foodrelated areas (median 5.8 U/g, maximum 591 U/g), as compared with levels in the classroom (median 2.4 U/g, maximum 186 U/g).…”

Section: Characteristics Of Cockroach Allergensmentioning

confidence: 97%

Cockroach allergens: Environmental distribution and relationship to disease

Arruda

Ferriani²,

Vailes³

et al. 2001

Curr Allergy Asthma Rep

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Cockroach allergy has been recognized as an important cause of asthma. Exposure to high levels of cockroach allergens in the home is a major risk factor for symptoms in sensitized individuals. Previously identified allergens from Blatella germanica and Periplaneta americana include Bla g 2 (inactive aspartic proteinase), Bla g 4 (calycin), Bla g 5 (glutathione-S-transferase), Bla g 6 (troponin), the Group 1 cross-reactive allergens Bla g 1 and Per a 1, Per a 3 (arylphorin), and Per a 7 (tropomyosin). The primary site of cockroach allergen accumulation is the kitchen. However, lower levels of allergen can be found in bedding, on the bedroom floor, and in sofa dust. Strategies for decreasing exposure to cockroach have been investigated. The results suggest that a sustained decrease in cockroach allergen levels is difficult to accomplish, even after successful extermination of cockroach populations. The use of recombinant cockroach allergens may lead to the development of new approaches to asthma treatment in the future.

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Section: Characteristics Of Cockroach Allergensmentioning

confidence: 97%

Cockroach allergens: Environmental distribution and relationship to disease

Arruda

Ferriani²,

Vailes³

et al. 2001

Curr Allergy Asthma Rep

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“…Cockroach allergen in urban households has been well described; however, many studies over the past decade also showed cockroach allergen to be an important source of allergen exposure in schools. Further evidence demonstrated cockroach allergen in schools to be present in levels suffi cient to induce allergic sensitization [40,41].…”

Section: Cockroachmentioning

confidence: 99%

Home and school environmental assessment and remediation

Lupoli

Ciaccio²,

Portnoy³

2009

Curr Allergy Asthma Rep

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Children spend a considerable portion of their time indoors. Therefore, homes and schools are an important source of allergen exposure. Chronic exposure to the major indoor allergens can lead to allergic sensitization and provoke allergic symptoms in children. Environmental assessment is crucial for the identification and quantification of such allergens in indoor spaces. Reduction of allergen exposure below sensitization and symptom thresholds is possible with various remediation techniques. This article reviews and discusses evidence for the assessment and remediation of indoor allergens commonly found in homes and schools. A literature review was performed using the PubMed database for English-language articles published between January 1, 1980, and February 2009. Additional information was obtained from a review of recent textbooks and one professional society's webpage.

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“…Exposure to cockroach allergen is reported to be a major risk factor for children with asthma in inner-city schools (45,225). A study of inner-city residences in seven major urban areas of the United States found that Bla g 1 was the predominant indoor allergen compared with mite and cat allergens (65,67,219).…”

Section: Cockroachesmentioning

confidence: 99%

Arthropod Allergens and Human Health

Arlian

2002

Annu. Rev. Entomol.

157

114

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Many species of arthropods are the sources of potent allergens that sensitize and induce IgE-mediated allergic reactions in humans. Most of these arthropod allergens are proteins, and the allergic response mechanism to these allergens is the same as it is for allergens from other sources such as plant pollens, molds, and foods. Aside from ingestion of crustaceans (shrimp, lobster), among arthropods, humans have the greatest contact with insects and mites, and as a result allergies to these two groups of arthropods have been the most frequently reported. Because of the large number of people affected by allergic reactions to stinging insects, cockroaches, and dust mites, many allergens of these organisms have been extensively studied, purified, and immunobiochemically characterized and for some recombinant allergens, produced. Cocktails of these recombinant allergens have the potential for use in diagnosis and immunotherapy. In this chapter, we review the insects and mites that induce allergic reactions. Where the information exists, the immunobiochemical characterization of the allergens and the frequency of sensitivity or clinical reactivity in the human population are also reviewed. As background, the beginning of this review includes sections that define allergens, explain the allergic reaction mechanism, and describe the methods for naming allergens.

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Cockroach allergen (Bla g 1) in school dust

Cited by 62 publications

References 17 publications

Cockroach allergens: Environmental distribution and relationship to disease

Cockroach allergens: Environmental distribution and relationship to disease

Home and school environmental assessment and remediation

Arthropod Allergens and Human Health

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