Cockroach allergy appears early in life in inner-city children with recurrent wheezing

Alp, Hande; Yu, Byung-Ho; Grant, Evalyn N.; Rao, Veena; Moy, James N.

doi:10.1016/s1081-1206(10)62355-1

Cited by 26 publications

(11 citation statements)

References 21 publications

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“…For example, in inner-city areas of the United States, where exposure to cockroach allergen is common, sensitivity to cockroaches starts early in life and may be the only sensitizing allergen in many young, inner-city children [18]. In places in which dust mites cannot thrive, other allergens, such as Alternaria spp, assume importance [19].…”

Section: Exposure To Indoor Allergens and Sensitizationmentioning

confidence: 99%

Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Arshad

2009

Curr Allergy Asthma Rep

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Common indoor allergens include house dust mite, cockroach, animal dander, and certain molds. In genetically susceptible children, exposure to these indoor allergens during the critical postnatal period may lead to sensitization in early childhood. Consistent evidence indicates that children sensitized to common indoor allergens are at several-fold higher risk of asthma and allergy. Due to conflicting evidence from prospective studies, some doubt remains regarding a direct and dose-response relationship between exposure and development of asthma. However, in recent years, evidence has accumulated that exposure to indoor allergen causes asthma and allergy, but this effect may depend on dose and type of allergen as well as the underlying genetic susceptibility of the child.

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Section: Exposure To Indoor Allergens and Sensitizationmentioning

confidence: 99%

Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Arshad

2009

Curr Allergy Asthma Rep

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“…Children exposed to cats in the first 2 years of life were sensitized to cat by age 4 and were at increased risk of severe asthma in the presence of secondhand tobacco smoke (Melen et al 2001). Cockroach sensitization, which often occurs at a very early age in exposed children (Alp et al 2001), has been associated with increased risk of incident asthma (Litonjua et al 2001). In a farming environment, children exposed to stables in the first year of life had reduced risk of asthma compared with children who had such exposure after 1 year of age (Riedler et al 2001).…”

mentioning

confidence: 99%

Early-life environmental risk factors for asthma: findings from the Children's Health Study.

Salam

Langholz

et al. 2004

Environ Health Perspect

181

107

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Early-life experiences and environmental exposures have been associated with childhood asthma. To investigate further whether the timing of such experiences and exposures is associated with the occurrence of asthma by 5 years of age, we conducted a prevalence case-control study nested within the Children's Health Study, a population-based study of > 4,000 school-aged children in 12 southern California communities. Cases were defined as physician-diagnosed asthma by age 5, and controls were asthma-free at study entry, frequency-matched on age, sex, and community of residence and countermatched on in utero exposure to maternal smoking. Telephone interviews were conducted with mothers to collect additional exposure and asthma histories. Conditional logistic regression models were fitted to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Asthma diagnosis before 5 years of age was associated with exposures in the first year of life to wood or oil smoke, soot, or exhaust (

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“…Convincing arguments are also made for the importance of genetic factors in the etiology of asthma (Alp et al, 2001;Bener, Al-Jawadi, Ozkaragov, Al-Frayh, & Gomes, 1993b;Johnson et al, 2002;Litonjua et al, 2001;Waser et al, 2005;Weiss & Sullivan, 2001). It seems likely that both environmental factors, such as exposure to pets, and genetic factors complement each other in the development of asthma.…”

Section: Discussionmentioning

confidence: 99%

“…For example, the risks for asthma development associated with exposure to pets, cockroaches, or farming environment appear to vary by age at exposure (Waser et al, 2005). Cockroach sensitization, which often occurs at a very early age in exposed children (Alp, Yu, Grant, Rao, & Moy, 2001), has been associated with increased risk of incident asthma (Liccardi et al, 2005;Litonjua, Carey, Burge, Weiss, & Gold, 2001).…”

Section: Introductionmentioning

confidence: 99%

Pet ownership and associated respiratory diseases

2006

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Background Studies have shown that pets are very important sensitizing agents in patients with asthma. Respiratory disorders and allergic diseases are common in the State of Qatar. Objective The aim of the present study was to determine whether exposure to pets and domestic animals plays a significant role in the development of asthma and allergic rhinitis among Qatari school children aged 6-14 years. Design A cross-sectional prospective study. Setting Public schools for boys and girls in urban and semi-urban areas. Subjects A total of 3,500 Qatari school boys and girls aged 6-14 years were approached. After exclusion of those who did not give consent for the study and incomplete questionnaires, 3,283 (98.3%) participants were included in the data analysis. Methods A multistage sampling technique was used and different schools from urban and semiurban areas were selected. A standard questionnaire was distributed to parents of randomly selected school children aged 6-14 years between February 2003 and February 2004. Results The overall prevalence of asthma was 19.8% and the mean age of the children was 9.0 ± 2.0 years. The male and female percentages were 52.3% and 47.7% respectively. Nine hundred and ninety-six families out of 3,283 (30.3%) owned pets. It was found that among children with no family history of asthma, the relative risk (RR) of asthma with pets at home was 1.19 and the 95% confidence interval (CI) was 1.0-1.4 (P = 0.025). The RR of having allergic rhinitis was 1.60 (95% CI = 1.4-1.8; P < 0.001) and risk of having eczema was also significantly higher in participants with pets at home (RR = 1.28; 95% CI = 1.1-1.5; P < 0.001). Conclusion In the present study, the prevalence of asthma, allergic rhinitis, and eczema was significantly more common in families with domestic animals than in those without.

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Cockroach allergy appears early in life in inner-city children with recurrent wheezing

Cited by 26 publications

References 21 publications

Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Early-life environmental risk factors for asthma: findings from the Children's Health Study.

Pet ownership and associated respiratory diseases

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