Cockroach extract antigen increases bronchial airway epithelial permeability

Antony, Ajay; Tepper, Robert S.; Mohammed, Kamal A.

doi:10.1067/mai.2002.127798

Cited by 63 publications

(52 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Respiratory syncytial virus stimulates increased VEGF protein biosynthesis in transformed alveolar epithelial cells (24). In vitro data have also shown that cockroach antigen alters bronchial airway epithelial permeability through increased VEGF release (25). In the current study, in vitro data demonstrated a dose-dependent increase in VEGF protein production.…”

Section: Discussionsupporting

confidence: 59%

Vascular Remodeling Is Airway Generation-Specific in a Primate Model of Chronic Asthma

Avdalovic

Putney

Schelegle

et al. 2006

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Changes in the density of bronchial vessels have been proposed as a part of airway remodeling that occurs in chronic asthma. Objectives: Using an established nonhuman primate model of chronic allergic asthma, we evaluated changes in vascular density as well as the contribution of bronchial epithelium to produce vascular endothelial growth factor (VEGF). Methods: Eight juvenile rhesus macaques were divided into two groups of four. One group was exposed to 11 cycles of aerosolized house dust mite allergen (HDMA), whereas the other was exposed to filtered air. Bronchial wall vasculature was identified using an immunohistochemical approach, and vascular density was quantified stereologically. A semiquantitative polymerase chain reaction approach was used to estimate VEGF splice variant gene expression at discrete airway generations. Cell culture of primary tracheal epithelial cells with varying concentrations of HDMA was used to quantify the direct contribution of the epithelium to VEGF production. Results: Bronchial vascular density was increased at mid-to lower airway generations, which was independent of changes in the interstitial compartment. The VEGF 121 splice variant was significantly increased at lower airway generations. VEGF protein increased in a dose-dependant fashion in vitro primarily by an increase in VEGF 121 gene expression. Conclusion: This study highlights that increased vascular density in an animal model of chronic allergic asthma is airway generation specific and associated with a unique increase of VEGF splice variant gene expression. Airway epithelium is the likely source for increased VEGF.

show abstract

Section: Discussionsupporting

confidence: 59%

Vascular Remodeling Is Airway Generation-Specific in a Primate Model of Chronic Asthma

Avdalovic

Putney

Schelegle

et al. 2006

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…In keeping with these findings, exaggerated levels of VEGF that correlate directly with disease activity (12) and inversely with airway caliber and airway hyperresponsiveness (AHR) (11,(15)(16)(17) have been detected in biologic samples from patients with asthma (7,11,(15)(16)(17). VEGF was originally postulated to contribute to asthma via its effects on vascular permeability (10,18). However, recent studies from our laboratory refined this concept by demonstrating that the overexpression of VEGF in the murine lung induces an asthma-like phenotype with inflammation, parenchymal and vascular remodeling, edema, mucus metaplasia, myocyte hyperplasia, AHR, dendritic cell (DC) hyperplasia and activation, enhanced respiratory antigen sensitization, and augmented Th2 inflammation (7).…”

mentioning

confidence: 62%

Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung

Bhandari

Choo-Wing

Chapoval

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

105

View full text Add to dashboard Cite

VEGF, nitric oxide (NO), inflammation, and vascular-and extravascular remodeling coexist in asthma and other disorders. In these responses, VEGF regulates angiogenesis. VEGF also induces inflammation and remodeling. The mechanisms of the latter responses have not been defined, however. We hypothesized that VEGFinduces extravascular tissue responses via NO-dependent mechanisms. To evaluate this hypothesis, we compared the effects of transgenic VEGF 165 in lungs from normal mice, mice treated with pan-NO synthase (NOS) or endothelial NOS (eNOS) inhibitors, and mice with null mutations of inducible NOS (iNOS) or eNOS. These studies demonstrate that VEGF selectively stimulates eNOS and iNOS. They also demonstrate that VEGF induces pulmonary alterations via NO-dependent and -independent mechanisms with angiogenesis, edema, mucus metaplasia, airway hyperresponsiveness, lymphocyte accumulation, dendritic cell hyperplasia and S-nitrosoglutathione reductase stimulation being NO-dependent and dendritic cell activation being NO-independent. Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO͞NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling.

show abstract

“…Similarly, exposure to cockroach allergen was associated with almost a 2-fold increased risk of wheeze in the first year of life (Belanger et al 2003;Gold et al 1999). In recent reports, cockroach allergen was found to alter bronchial airway epithelial cell permeability by induction of vascular endothelial growth factor (Antony et al 2002) and was significantly associated with specific serum immunoglobulin E (IgE) levels (Bener al. 2002).…”

Section: Discussionmentioning

confidence: 99%

Early-life environmental risk factors for asthma: findings from the Children's Health Study.

Salam

Langholz

et al. 2004

Environ Health Perspect

181

107

View full text Add to dashboard Cite

Early-life experiences and environmental exposures have been associated with childhood asthma. To investigate further whether the timing of such experiences and exposures is associated with the occurrence of asthma by 5 years of age, we conducted a prevalence case-control study nested within the Children's Health Study, a population-based study of > 4,000 school-aged children in 12 southern California communities. Cases were defined as physician-diagnosed asthma by age 5, and controls were asthma-free at study entry, frequency-matched on age, sex, and community of residence and countermatched on in utero exposure to maternal smoking. Telephone interviews were conducted with mothers to collect additional exposure and asthma histories. Conditional logistic regression models were fitted to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Asthma diagnosis before 5 years of age was associated with exposures in the first year of life to wood or oil smoke, soot, or exhaust (

show abstract

Cockroach extract antigen increases bronchial airway epithelial permeability

Cited by 63 publications

References 24 publications

Vascular Remodeling Is Airway Generation-Specific in a Primate Model of Chronic Asthma

Vascular Remodeling Is Airway Generation-Specific in a Primate Model of Chronic Asthma

Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung

Early-life environmental risk factors for asthma: findings from the Children's Health Study.

Contact Info

Product

Resources

About