2020
DOI: 10.1016/j.foodres.2020.109058
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Cocoa diet modulates gut microbiota composition and improves intestinal health in Zucker diabetic rats

Abstract: Cocoa supplementation improves glucose metabolism in Zucker diabetic fatty (ZDF) rats via multiple mechanisms. Furthermore, cocoa rich-diets modify the intestinal microbiota composition both in humans and rats in healthy conditions. Accordingly, we hypothesized that cocoa could interact with the gut microbiota (GM) in ZDF rats, contributing to their antidiabetic effects. Therefore, here we investigate the effect of cocoa intake on gut health and GM in ZDF diabetic rats.Male ZDF rats were fed with standard (ZDF… Show more

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Cited by 46 publications
(41 citation statements)
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“…On the other hand, Massot-Cladera et al [56] investigated the impact of cocoa, cocoa fiber, or inulin on the gut microbiota composition in Wistar rats. It was reported that phenolic compounds and other substances, like theobromine found in whole cocoa, may influence the fermentation of the fiber through both anti-bacterial and prebiotic actions against gut bacteria [30,56,57]. Thus, we can conclude that replacing cellulose with CBEs that contained phenolic compounds and methylxanthines may affect bacteria colonizing the last part of the digestive tract and may have a trophic effect on the cecum and colon of rats [59].…”
Section: Resultsmentioning
confidence: 75%
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“…On the other hand, Massot-Cladera et al [56] investigated the impact of cocoa, cocoa fiber, or inulin on the gut microbiota composition in Wistar rats. It was reported that phenolic compounds and other substances, like theobromine found in whole cocoa, may influence the fermentation of the fiber through both anti-bacterial and prebiotic actions against gut bacteria [30,56,57]. Thus, we can conclude that replacing cellulose with CBEs that contained phenolic compounds and methylxanthines may affect bacteria colonizing the last part of the digestive tract and may have a trophic effect on the cecum and colon of rats [59].…”
Section: Resultsmentioning
confidence: 75%
“…This possibility was also indicated in the study conducted by Álvarez-Cilleros et al [30] where cocoa intake modified the gut bacterial composition towards a healthier profile of microbiota in diabetic rats [30]. The authors suggested that alterations in the gut microbiota improve glucose homeostasis and this phenomenon could be associated with the potential anti-obesity mechanisms of cocoa polyphenols include improvement glucose homeostasis and gut health [30,31].…”
Section: Resultsmentioning
confidence: 85%
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“…Thus, an increase in the Lactobacillaceae family was observed in mice fed industrially-generated trans-fatty acids, an effect further confirmed by in vitro fermentation of these compounds by the family Lactobacillaceae and the genus Lactobacillus [43]. A tendency towards an increase in Lactobacilliales was observed in subjects with Behcet's syndrome, a systemic inflammatory condition [44] and, recently, an increase in the genus Lactobacillus has been reported in diabetic rats, being significantly associated with an increase in body weight and adverse modification in biomarkers of glucose homeostasis and inflammation [45]. While it is still not clear whether the increase in Lactobacilliales in these adverse situations is a cause or a consequence, after observing an increase in several Lactobacillus spp.…”
Section: Discussionmentioning
confidence: 79%