Coconut oil induces short-term changes in lipid composition and enzyme activity of chick hepatic mitochondria

Gil-Villarino, Almudena; Garcı́a-Fuentes, Eduardo; Zafra, M. F.; Garcia-Peregrin, E.

doi:10.1016/s0955-2863(99)00004-2

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…Thus, at early time points we observed increased viability, which came down to the level of control cells at later time points. Similar rapid response (after 24 h treatment with CO) for elevated mitochondrial functioning was observed by Gil-Villarino et al (1999) in hepatic tissue. The authors showed that in chicks fed with CO oil, up-regulation in the mitochondrial function was seen after 24 h but the up-regulated mitochondrial functioning returned back to the level of controls at longer treatment time points of CO feeding.…”

Section: Assessment Of the Effects Of Co Blends On The Thp-1 Cell Linesupporting

confidence: 73%

Modulation of essential fatty acid levels in coconut oil with flaxseed oil

2023

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Coconut oil (CO) is a popular cooking medium but its lack of essential fatty acids (FA) is a health concern. Therefore, the aim of this work was to improve the FA profile of CO by blending with flaxseed oil (FO). Blends with various percentages of FO were prepared and studied for physicochemical characterization, thermal and long-term storage stability. The results indicated that the blends made favorable alterations in FA composition without adverse effects to the oxidative stability of the fatty acids and they resisted secondary thermal deterioration up to two hours at 180 ºC. The blend with the highest percentage of FO was stable for nine months. THP-1 cell line studies showed that ω-3 FA from the blend was incorporated into the cells with no adverse effect on cell viability but the inflammatory markers studied remained unaltered. Thus, CO and FO blends could be stored for at least nine months and could be used as cooking medium when prolonged heating is not involved.

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Section: Assessment Of the Effects Of Co Blends On The Thp-1 Cell Linesupporting

confidence: 73%

Modulation of essential fatty acid levels in coconut oil with flaxseed oil

2023

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“…In this study, the influence of the most commonly consumed dietary oils in chick liver performace was determined by measuring the levels of free-radical oxygen metabolities and the acitivities of the markers of liver dysfunction. The chick has been recognized as a suitable animal model for studies on the lipid metabolism because it is highly sensitive and responds very rapidly to the manipulations in the composition of lipids (Chandler et al, 1979;Gil-Villarino et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Effects of Highly Consumed Dietary Oils on Several Hepatic Transaminases and Lipid Oxidation in Chick

Yöntem

Ergun

Yerlikaya

et al. 2005

Ecology of Food and Nutrition

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Changes in plasma lipid composition induced by coconut oil. Effects of dipyridamole

Garcı́a-Fuentes

Gil-Villarino

Zafra

et al. 2002

J. Physiol. Biochem.

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The comparative effects of 10-20% coconut oil feeding on fatty acid composition of the main lipid classes of chick plasma have been studied with and without simultaneous treatment with dipyridamole in order to clarify the hypolipidemic role of this drug. Coconut oil drastically increased the percentages of lauric and myristic acids in free fatty acid and triacylglycerol fractions, whereas these changes were less pronounced in phospholipids and cholesterol esters. The percentage of arachidonic acid was higher in plasma phospholipids than in the other fractions and was significantly decreased by coconut oil feeding. Linoleic acid, the main fatty acid of cholesterol esters, was drastically increased by coconut oil feeding. Changes induced by the simultaneous administration of dipyridamole were more pronounced in the phospholipids and cholesterol esters than in the other fractions. The fall observed in linoleic acid levels after dipyridamole treatment may be of interest for a lower production of its derived eicosanoids, especially in plasma phospholipids and cholesterol esters.

show abstract

Coconut oil induces short-term changes in lipid composition and enzyme activity of chick hepatic mitochondria

Cited by 6 publications

References 40 publications

Modulation of essential fatty acid levels in coconut oil with flaxseed oil

Modulation of essential fatty acid levels in coconut oil with flaxseed oil

Effects of Highly Consumed Dietary Oils on Several Hepatic Transaminases and Lipid Oxidation in Chick

Changes in plasma lipid composition induced by coconut oil. Effects of dipyridamole

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