CoCrMo Alloy for Biomedical Applications

Milošev, Ingrid

doi:10.1007/978-1-4614-3125-1_1

Cited by 44 publications

(40 citation statements)

References 128 publications

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“…Important to us, the authors find that this alloy exhibits much higher corrosion resistance than the conventional CoCrMo and 316LSS alloys used for bone implants, as well as high yield strength, with a Vickers microhardness of 4.9 GPa and Young's modulus of 153 GPa. This value of Young's modulus is lower than the values for CoCrMo (240 GPa) and 316LSS (193 GPa) alloys and thus is closer to that of bones [29].…”

Section: Introductionmentioning

confidence: 46%

Elastic properties of the TiZrNbTaMo multi-principal element alloy studied from first principles

et al. 2019

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The TiZrNbTaMo multi-principal element alloy has been postulated as a new potential material for biomedical applications, such as orthopedic implants. Besides the good biocompatibility of the constituent atoms, the TiZrNbTaMo alloy also exhibits excellent corrosion resistance and mechanical properties, according to recent experimental studies. Motivated by these experiments, here we investigate with density functional theory (DFT) the structure, as well as the elastic and electronic properties, of the equiatomic and nearly-equiatomic TiZrNbTaMo alloys. By combining evolutionary algorithms with DFT calculations of the energy, we can correctly predict the crystal structures of the two phases that are identified in experiments. The corresponding elastic properties, which are also calculated with DFT, are in good qualitative agreement with the experimental observations. The analysis of the electronic properties allows us to explain the differences in the elastic moduli between the two phases in terms of the differences in both the electron density distribution and the bonding-states occupation.

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Section: Introductionmentioning

confidence: 46%

Elastic properties of the TiZrNbTaMo multi-principal element alloy studied from first principles

et al. 2019

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“…Cobalt‐chromium‐molybdenum (CoCrMo) alloys are used extensively in orthopaedic applications . However, these alloys can undergo wear and corrosion in vivo, leading to the release of Co and Cr ions, which are a potential health concern .…”

mentioning

confidence: 99%

Effects of cobalt and chromium ions on oxidative stress and energy metabolism in macrophages in vitro

Salloum

Lehoux

Harper

et al. 2018

Journal Orthopaedic Research

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Cobalt and chromium ions released from cobalt-chromium-molybdenum (CoCrMo)-based implants are a potential health concern, especially since both ions have been shown to induce oxidative stress in macrophages, the predominant immune cells in periprosthetic tissues. Ions of other transition metals (Cd, Ni) have been reported to inhibit the activity of mitochondrial enzymes in the electron transport chain. However, the effects of Co and Cr ions on the energy metabolism of macrophages remain largely unknown. The objective of the present study was to analyze the effects of Co and Cr on oxidative stress and energy metabolism in macrophages in vitro. RAW 264.7 murine macrophages were exposed to 6-18 ppm Co or 50-150 ppm Cr . Results showed a significant increase in two markers of oxidative stress, reactive oxygen species level and protein carbonyl content, with increasing concentrations of Co , but not with Cr . In addition, oxygen consumption rates (OCR; measured using an extracellular flux analyzer) showed significant decreases in both mitochondrial respiration and non-mitochondrial oxygen consumption with increasing concentrations of Co , but not with Cr . OCR results further showed that Co , but not Cr , induced mitochondrial dysfunction, including a decrease in oxidative phosphorylation capacity. Overall, this study suggests that mitochondrial dysfunction may contribute to Co -induced oxidative stress in macrophages, and thereby to the inflammatory response observed in periprosthetic tissues. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

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“…Cobalt-chrome alloys (CoCr) are commonly used for the MoM hip joints due to their substantially low corrosion and wear rates (Silva, Heisel, & Schmalzried, 2005;Yan, Neville, Dowson, & Williams, 2006;Yan, Neville, & Dowson, 2007). Their excellent corrosion resistance relies on the formation of very stable, continuous, highly adherent and protective passive film on the metallic surface (Milosev, 2012). This passive film prevents degradation of the alloys as is one of the kinetic barriers preventing implant corrosion (Arnholt et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Osteoblasts MC3T3-E1 Response in 2D and 3D Cell Cultures Models to High Carbon Content CoCr Alloy Particles. Effect of Metallic Particles on Vimentin Expression

Pérez-Maceda¹,

López-Fernández²,

Díaz³

et al. 2017

JMSR

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The study of the biocompability of the metallic materials is a priority treating to avoid the osteolysis and aseptic loosening of prosthesis. Wear debris is considered one of the main factors responsible for aseptic loosening of orthopedic endoprostheses. We examined the response of mouse osteoblasts MC3T3-E1 to high carbon cobalt-chrome (HCCoCr) particles obtained a) from wear-corrosion assays on a pin-on-disk tribometer using as pair an alumina ball and a disc of a HCCoCr alloy, and b) HCCoCr bulk particles obtained by nitrogen gas atomization from an alloy used in clinic for prostheses application. Mitochondrial activity and lactate dehydrogenase activity assayed in 2D and 3D osteoblasts cell culture models were used to evaluate the cellular response to size, shape, and chemical composition of the metallic particles. 2D cell model was used to study the direct interaction of cells with particles and 3D cell cultures was used to more closely mimic in vivo conditions. The results showed that vimentin was overexpressed in the 2D osteoblasts cultures in presence of metal particles. This might be related to the appearance of pseudotumor in the peri-prosthetic vicinity described in some implanted patients.

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CoCrMo Alloy for Biomedical Applications

Cited by 44 publications

References 128 publications

Elastic properties of the TiZrNbTaMo multi-principal element alloy studied from first principles

Elastic properties of the TiZrNbTaMo multi-principal element alloy studied from first principles

Effects of cobalt and chromium ions on oxidative stress and energy metabolism in macrophages in vitro

Osteoblasts MC3T3-E1 Response in 2D and 3D Cell Cultures Models to High Carbon Content CoCr Alloy Particles. Effect of Metallic Particles on Vimentin Expression

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