Cocrystallization as a tool to stabilize liquid active ingredients

On the Mechanism of Cocrystal Mechanochemical Reaction via Low Melting Eutectic: A Time-Resolved In Situ Monitoring Investigation

“…Cocrystals are crystalline compounds made of different molecular entities taken together by intermolecular forces within the same crystal structure. − Cocrystallization has been largely investigated in the modern literature − since the novel intermolecular networks established between the molecular species involved can tune the physical characteristics ,, (e.g., solubility, volatility, melting point) of the single molecular entities when in their pure form. A direct correlation of crystal structure/properties is at the basis of the cocrystal design and application of molecular materials. ,, …”

Hybrid interaction network of guanidinium–biphenyldisulfonic acid for the structure determination of liquid molecules

“…15 However, the largest guest was muscone with a molecular weight of 238 g mol −1 . In addition, a lot of research studies on co-crystallization of liquid ingredients with various coformers have been reported; 16 for example, the structures of nicotine, 17 propofol, 18 essential oils, 19 pyrazine derivatives, 21 and liquid explosives 20 have been published. Recently, guanidinium-phenylsulfonates have drawn our attention because there are reports that these coformers can form co-crystals with several compounds through inter-molecular or intra-molecular π-π interactions.…”

Interfacial Cocrystallization Using Oily Phase via Liquid–Liquid Phase Separation

“…This accelerated the production of crystals from the nucleating oily phase. Previously, cocrystallization has been used to stabilize liquids; however, this is the first report of exploiting cocrystallization to minimize drug losses due to LLPS, reducing waste and preventing disposal complexities arising, thus providing an economic benefit. , The solute-rich oily phase is transformed to cocrystals by the addition of a suitable coformer.…”