2012
DOI: 10.1021/cg301314w
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Cocrystals of Active Pharmaceutical Ingredients—Praziquantel in Combination with Oxalic, Malonic, Succinic, Maleic, Fumaric, Glutaric, Adipic, And Pimelic Acids

Abstract: The combination of racemic praziquantel, (RS)-PZQ, with aliphatic dicarboxylic acids of the homologous series HOOC−(CH 2 ) n −COOH (with n = 0−8) and the unsaturated analogues of succinic acid as cocrystal formers via liquid-assisted grinding provided a total of nine 1:1 and 2:1 cocrystals with oxalic acid, malonic acid, succinic acid (two polymorphic phases), maleic acid, fumaric acid, glutaric acid, adipic acid, and pimelic acid. The cocrystalline phases were identified first by XRPD analysis and then struct… Show more

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Cited by 85 publications
(118 citation statements)
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“…Hydrogen bonding, one of non-covalent bonding, is involved in the formation of cocrystal. The formation of cocrystal potentially shifts the peak, decreases the peak intensity, diminishes peak and produces new peaks in FTIR spectra [2,10,12]. The result showed that Pm Qu-Ma and Co Qu-Ma slighty shifted the IR band of -OH functional group of quercetin.…”
Section: Fourier Transforms Infrared Spectroscopy (Ftir)mentioning
confidence: 96%
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“…Hydrogen bonding, one of non-covalent bonding, is involved in the formation of cocrystal. The formation of cocrystal potentially shifts the peak, decreases the peak intensity, diminishes peak and produces new peaks in FTIR spectra [2,10,12]. The result showed that Pm Qu-Ma and Co Qu-Ma slighty shifted the IR band of -OH functional group of quercetin.…”
Section: Fourier Transforms Infrared Spectroscopy (Ftir)mentioning
confidence: 96%
“…It has been reported that quercetin cocrystals were successfully produced using several coformers such as caffeine, isonicotinamide and theobromine. Previous finding showed that cocrystallization with caffeine increased water solubility of quercetin up to 8 times compared to the pure quercetin [8][9][10][11][12][13]. Nevertheless, none has been reported for the cocrystallization of quercetin with malonic acid as coformer.…”
Section: Introductionmentioning
confidence: 99%
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“…The rule may be interpreted according to the solubility ability of coformers. Salt solubility is directly associated with the solubility of the coformer, which indicates that more soluble coformers lead to more soluble salts [12]. The powder samples of the undissolved residue are also analyzed via PXRD, the result shows that all VOT salts remained stable in water at 37 °C after 24 h solubility experiments ( Figures S3-S5).…”
Section: Solubility and Powder Dissolution Rate Analysismentioning
confidence: 99%
“…This is especially true for drug salt or drug salt hydrate formation, which can usually improve the solubility of poorly soluble drugs. For example, there have been many researches on the significant solubility improvement of such drugs by forming cocrystals or salts with oxalic acid, malonic acid, and succinic acid [11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%