A generalised transmit-receive joint spatial modulation (GTRSM) scheme is proposed, which amalgamates both transmitter-and receiver-side spatial modulation (SM) schemes. The proposed GTRSM jointly employs the combinations of multiple instead of a single activated transmit and receive antennas and baseband symbols to transmit information. The optimal maximum-likelihood detector for GTRSM is formulated, and the channel capacity of GTRSM is also analysed. Simulated results demonstrate that the proposed GTRSM behaves good BER performance and can significantly improve the channel capacity compared with conventional SMs.