Coding of information about tactile stimuli by neurones of the cuneate nucleus.

Douglas, Peter; Ferrington, D. G.; Rowe, Mark J.

doi:10.1113/jphysiol.1978.sp012585

Cited by 70 publications

(110 citation statements)

References 46 publications

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“…to poorer phase locking in central neurones cpmpared with primary fibres (Douglas, Ferrington & Rowe, 1978;Ferrington & Rowe, 1980a;Connor, Ferrington & Rowe, 1984), is attributable to variations in the phase of spike initiation in different P.c. fibres and to differences among P.c.…”

Section: G Ferrington S Horniblo W and M J Rowementioning

confidence: 99%

“…In addition, some data for cuneate neurones were included from our earlier study (Douglas et al 1978). Anaesthesia was induced with Saffan (Glaxo) and maintained with halothane.…”

Section: Animal Preparationmentioning

confidence: 99%

“…Their fields and points of peak sensitivity were delineated by gentle tapping with a small probe or by using a von Frey hair. Precise and reproducible mechanical stimuli (Douglas et al 1978;Bennett, Ferrington & Rowe, 1980;Ferrington & Rowe, 1980a, b, 1982 were applied to the point of maximum sensitivity within the excitatory receptive field of the neurone using a 2 mm diameter circular probe with a flat contact surface. Stimuli consisted of a 1-5 s duration step indentation (rise time 30 ms, amplitude 670 anm) on which a 1 s train of sinusoidal vibration was superimposed.…”

Section: Recording and Stimulation Proceduresmentioning

confidence: 99%

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Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Ferrington

Horniblow

Rowe

1987

The Journal of Physiology

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SUMMARY1. Recordings were made in decerebrate cats from gracile and cuneate neurones responding to vibration-induced inputs from Pacinian corpuscle (P.c.) receptors of the hind-limb and forelimb footpads. The two groups of neurones were compared, in particular for their capacities for responding to cutaneous vibration with phaselocked impulse patterns.2. In both nuclei the P.c. neurones were most sensitive to vibration in the range 80 to > 600 Hz. Stimulus-response relations were similar for the two groups, as were measures derived from these relations such as response levels, absolute thresholds and the dynamic range (defined as the vibration amplitude range over which responses were graded).

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Section: G Ferrington S Horniblo W and M J Rowementioning

confidence: 99%

“…In addition, some data for cuneate neurones were included from our earlier study (Douglas et al 1978). Anaesthesia was induced with Saffan (Glaxo) and maintained with halothane.…”

Section: Animal Preparationmentioning

confidence: 99%

Section: Recording and Stimulation Proceduresmentioning

confidence: 99%

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Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Ferrington

Horniblow

Rowe

1987

The Journal of Physiology

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“…Low-threshold mechanoreceptive fibers maintain a somatotopic arrangement up to the cuneatus and gracilis nuclei (Uddenberg, 1966;Whitsel et al, 1969), where they synapse onto submodality-specific neurons segregated rostrocaudally (Kruger et al, 1961;Perl et al, 1962;Gordon and Jukes, 1964;Rosén, 1969a;Carmody and Rowe, 1974;Millar and Basbaum, 1975;Bystrzycka et al, 1977;Douglas et al, 1978;Golovchinsky, 1980;Dykes et al, 1982;Berkley et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Leiras¹,

Velo²,

Martín-Cora³

et al. 2010

J. Neurosci.

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Medial lemniscal activity decreases before and during movement, suggesting prethalamic modulation, but the underlying mechanisms are largely unknown. Here we studied the mechanisms underlying proprioceptive transmission at the midventral cuneate nucleus (mvCN) of anesthetized cats using standard extracellular recordings combined with electrical stimulation and microiontophoresis. Dual simultaneous recordings from mvCN and rostroventral cuneate (rvCN) proprioceptive neurons demonstrated that microstimulation through the rvCN recording electrode induced dual effects on mvCN projection cells: potentiation when both neurons had excitatory receptive fields in muscles acting at the same joint, and inhibition when rvCN and mvCN cells had receptive fields located in different joints. GABA and/or glycine consistently abolished mvCN spontaneous and sensory-evoked activity, an effect reversed by bicuculline and strychnine, respectively; and immunohistochemistry data revealed that cells possessing strychnine-sensitive glycine receptors were uniformly distributed throughout the cuneate nucleus. It was also found that proprioceptive mvCN projection cells sent ipsilateral collaterals to the nucleus reticularis gigantocellularis and the mesencephalic locomotor region, and had slower antidromic conduction speeds than cutaneous fibers from the more dorsally located cluster region.The data suggest that (1) the rvCN-mvCM network is functionally related to joints rather than to single muscles producing an overall potentiation of proprioceptive feedback from a moving forelimb joint while inhibiting, through GABAergic and glycinergic interneurons, deep muscular feedback from other forelimb joints; and (2) mvCN projection cells collateralizing to or through the ipsilateral reticular formation allow for bilateral spreading of ascending proprioceptive feedback information.

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“…Stimulation and analysis procedures were essentially similar to those described in a previous paper (Vickery et al 1992), and employed a feedback-controlled mechanical stimulator (Douglas, Ferrington & Rowe, 1978), with a flat-tipped probe (diameter between 0-25 and 2 mm), which was positioned (except in studies on the effect of skin stretch) perpendicular to, and just above the skin surface ( z 10 /tm). The tactile stimuli consisted of a step indentation of the skin up to 1 mm in amplitude, that lasted 1-5 s, and in cases where vibrotactile responsiveness was examined, a 1 s train of sinusoidal vibration was superimposed on the step and commenced 300 ms after its onset.…”

Section: Stimulation and Analysis Proceduresmentioning

confidence: 99%

Responses of slowly adapting type II afferent fibres in cat hairy skin to vibrotactile stimuli.

Gynther

Vickery

Rowe

1992

The Journal of Physiology

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SUMMARY1. Slowly adapting type II (SAII) afferent fibres that supply the forelimb were isolated from the medial cutaneous nerve of anaesthetized cats and examined for their capacity to signal information about vibrotactile events in the hairy skin.2. The SAII fibres had a single spot-like receptive field focus where they were highly sensitive to steady indentation and vibration applied with probes normal to the skin surface. However, their sensitivity was affected profoundly by the size of the stimulus probe, its position in relation to the receptive field focus and, to a lesser extent, the magnitude of any pre-indentation on which vibration was superimposed. Small stimulus probes (e.g. 250 ,tm diameter) were much more effective than larger (., 1-2 mm) ones, and small shifts in the position of the perpendicularly applied probe away from the receptive field focus led to a marked decline in responsiveness.3. With appropriate choice of stimulus parameters for vibratory stimuli applied at the receptive field focus, the SAII fibres could respond at low threshold (< 100 4ttm), with a tightly phase-locked, regular 1:1 impulse pattern (one impulse per vibration cycle) that accurately signalled the vibration frequency over a bandwidth that extended to 600 Hz. Furthermore, their responses remained phase-locked up to 1000 Hz. Phase-locking in SAII fibres was marginally tighter than that in SAI fibres and comparable to that of Pacinian corpuscle fibres.4. The sensitivity of forelimb SAII fibres to tangential skin stretch was directionally selective; stretch across the forelimb was much more effective than along its long axis. Vibration associated with tangential skin stretch led to a marked spatial expansion of the field of vibration sensitivity. SAII fibres could therefore signal information about natural stimuli that contain elements of skin stretch and vibration, as may be encountered when the forelimb brushes against textured surfaces. Should the SAII fibres fail to contribute to the sensory experience of vibrotactile stimuli, the explanation may be related to limitations imposed centrally on the processing of their signals. Nevertheless, the present results demonstrate that, with appropriate stimulus conditions, the SAII afferent fibres have much greater vibrotactile sensitivity than has been suggested by past studies. MS 11676 PHY 458

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Coding of information about tactile stimuli by neurones of the cuneate nucleus.

Cited by 70 publications

References 46 publications

Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Temporal patterning in the responses of gracile and cuneate neurones in the cat to cutaneous vibration.

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Responses of slowly adapting type II afferent fibres in cat hairy skin to vibrotactile stimuli.

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