1971
DOI: 10.1016/0022-5193(71)90091-9
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Codon-restriction theory of aging and development

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Cited by 120 publications
(17 citation statements)
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“…We will discuss the work of Frazer and Yang [1972] in relation to the codon-restriction hypothesis later. It is relevant here to mention that many findings consistent with error hypothesis are equally compatible with the codon-restriction hypothesis of Strehler et al [1971],…”
Section: Error Theories O F Agingmentioning
confidence: 62%
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“…We will discuss the work of Frazer and Yang [1972] in relation to the codon-restriction hypothesis later. It is relevant here to mention that many findings consistent with error hypothesis are equally compatible with the codon-restriction hypothesis of Strehler et al [1971],…”
Section: Error Theories O F Agingmentioning
confidence: 62%
“…In other schemes of programmed aging such as proposed by Von H ahn [1970], Krooth [1974] or Strehler et al [1971] clock mechanisms are simply postulated to operate by inducing a sequential change in macromolecular synthesis which would ultimately lead to the cellular aging. However, the latter group of models attempts to explain the regulation of transcription or of translations in detail.…”
Section: Theories O F Programmed Agingmentioning
confidence: 99%
“…A major concern is whether aging is controlled by genetically programmed mechanisms. Indirect evidence supports the concept that aging in plants is programmed (15, 24) while direct evidence is available for human cells (9,16 during aging (3,22). Changes in translation at these levels, as well as in rates of mRNA transcription, could reduce the synthesis of vital proteins or even favor the production of destructive proteins.…”
mentioning
confidence: 93%
“…during aging (3,22). Changes in translation at these levels, as well as in rates of mRNA transcription, could reduce the synthesis of vital proteins or even favor the production of destructive proteins.…”
mentioning
confidence: 99%
“…The possible roles of multiple forms of ARSase in the regulation of protein biosynthesis in eukaryotic cells have been discussed, in relation to cell differentiation (27).…”
mentioning
confidence: 99%