Coeliac disease and small bowel carcinoma

Kenwright, Simon

doi:10.1136/pgmj.48.565.673

Cited by 13 publications

(7 citation statements)

References 23 publications

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“…The association between CD and SBA was first described more than 40 years ago [9] and, in contrast to the general population, CD patients have a markedly increased risk of developing SBA. Nowadays it is largely agreed that a delay in CD diagnosis and a low compliance with gluten free diet (GFD) are two major factors leading to a 60–80 fold relative risk of developing SBA [10–12].…”

Section: Introductionmentioning

confidence: 99%

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features

et al. 2019

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Background Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal disorders, e.g. celiac disease (CD). However, the features of SBA in the context of CD remain only partly understood. This study was aimed to show the main clinical features, diagnostic procedures and management options of SBA cases detected in a large cohort of celiac patients diagnosed in a single tertiary care center. Methods We retrospectively reviewed all the SBA cases detected in a cohort of 770 CD patients (599 females; F / M ratio: 3.5:1; median age at diagnosis 36 years, range 18–80 years), diagnosed at the Celiac Disease Referral Center of our University Hospital (Bologna, Italy) from January 1995 to December 2014. Results Five (0.65%) out of our 770 CD patients developed SBA. All of them were female with a mean age of 53 years (range 38–72 years). SBA, diagnosed at the same time of the CD diagnosis in three cases, was localized in the jejunum in four cases and in the duodenum in one case. The clinical presentation of SBA was characterized by intestinal sub-occlusion in two cases, while the predominant manifestation of the remaining three cases was iron deficiency anaemia, abdominal pain and acute intestinal obstruction, respectively. All the patients were referred to surgery, and three cases with advanced stage neoplasia were also treated with chemotherapy. The overall survival rate at 5 years was 80%. Conclusions Although in a limited series, herein presented CD-related SBA cases were characterized by a younger age of onset, a higher prevalence in female gender and a better overall survival compared to sporadic, Crohn- and hereditary syndrome-related SBA.

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Section: Introductionmentioning

confidence: 99%

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features

et al. 2019

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“…4 Similar to the situation in the large bowel, there is evidence that small bowel adenocarcinomas also arise from pre-existing adenomas. 5 6 Although there have been many reported cases of small bowel adenocarcinoma developing in coeliac disease patients, [7][8][9][10][11][12][13][14][15] there has been only one published case of a small bowel adenoma in a patient with coeliac disease. 16 Within our cohort of patients with coeliac disease, we have encountered three patients with a small bowel adenoma and four with adenocarcinoma of the small bowel.…”

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confidence: 99%

Small bowel neoplasia in coeliac disease

Rampertab

2003

Gut

109

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“…Accordingly, among all SBC, 13% are associated with a diagnosis of CD [48]. The first case of SBC in CD was described in 1972 and, from that on, many other reports followed up [61].…”

Section: Cd-associated Small Bowel Carcinomamentioning

confidence: 99%

Association Between Celiac Disease and Cancer

Marafini

Monteleone

Stolfi

2020

IJMS

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Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.

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Coeliac disease and small bowel carcinoma

Cited by 13 publications

References 23 publications

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features

Small bowel neoplasia in coeliac disease

Association Between Celiac Disease and Cancer

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