Coeliac disease as the cause of resistant sideropenic anaemia in children with Down's syndrome: Case report

Pavlovic, Momcilo; Radlovic, Nedeljko; Lekovic, Zoran; Berenji, Karolina; Stojšić, Zorica; Radlovic, Vladimir

doi:10.2298/sarh1002091p

Cited by 3 publications

(2 citation statements)

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“…The consequences are among the most diverse, being able to include sideroblastic anemia resistant to iron treatment. This subsided when GFD was introduced into the therapeutic regimen ( 202 ). The pathogenic bases of the association are most likely aimed at immune and microbial imbalances, common to the three pathologies ( 203 , 204 ).…”

Section: Atypical Forms Of Celiac Diseasementioning

confidence: 99%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially in pediatrics, celiac disease (also called gluten enteropathy), is gaining more and more ground in terms of diagnosis, but also interest in research. The data from the literature of the last decades attest the chameleonic way of its presentation, there may be both classic onset symptoms and atypical symptoms. Given the impact played by celiac disease, especially in the optimal growth and development of children, the current narrative review aims to highlight the atypical presentation methods, intended to guide the clinician towards the inclusion of the pathology in the differential diagnosis scheme. To these we add the summary presentation of the general data and therapeutic lines regarding the underlying condition and the existing comorbidities. In order to place the related information up to date, we performed a literature review of the recent articles published in international databases. We bring forward the current theories and approaches regarding both classic celiac disease and its atypical manifestations. Among these we note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, but also disorders of biological constants and association with multiple autoimmunities. Knowing and correlating them with celiac disease is the key to optimal management of patients, thus reducing the subsequent burden of the disease.

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Section: Atypical Forms Of Celiac Diseasementioning

confidence: 99%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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“…After the recognition of antibodies to gluten in the serum of patients and the recognition of gluten-specific lymphocytes in the mucosa, CD was depicted as an autoimmune disorder that usually presents as enteropathy in genetically susceptible individuals like a chronic "gluten infection" (Zhernakova et al, 2010;Tommasini et al, 2011). It is (Pavlović et al, 2010). CD4(+) T cells have a vital function in CD, identifying and binding complexes bearing gluten peptides that have endured digestion and are deamidated by tissue transglutaminase (TG2) thus supporting disease progression (Lindfors et al, 2010;Huan et al, 2011).…”

Section: Celiac Diseasementioning

confidence: 99%

Wheat Allergy and Intolerence; Recent Updates and Perspectives

Pasha

Saeed

Sultan

et al. 2013

Critical Reviews in Food Science and Nutrition

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The current review paper highlights the complicacies associated with communities relying on wheat as their dietary staple. Although, wheat is an important source of nutrients but is also linked with allergenic responses in genetically susceptible subjects. The wheat proteins especially α-amylase inhibitors, ω-5 gliadins, prolamins, nonprolamin, glucoprotein, and profilins are of significance importance. The allergenic responses are further categorized into IgE-mediated and non-IgE-mediated reactions. Conjugation and degranulation of the IgEs with the allergens results in release of several mediators. In contrary, non-IgE-mediated wheat allergy depends on immune complexes formed by food and food antibodies and cell-mediated immunity. As results, different diseases tend to occur on the completion of these reactions, i.e., celiac disease, baker's asthma, diarrhea, atopic dermatitis, and urticaria. This instant paper highlighted the concept of food allergy with special reference to wheat. The models are developed that are included in this paper showing the wheat allergen, their possible routes, impact on human health, and indeed possible remedies. The paper would provide the basic information for the researchers, common man, and allied stakeholders to cater the issue in details. However, the issue needs the attention of the researchers as there is a need to clarify the issues of wheat allergy and wheat intolerance.

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