Coeliac disease, epilepsy and cerebral calcifications

Gobbi, Giuseppe

doi:10.1016/j.braindev.2004.05.003

Cited by 104 publications

(66 citation statements)

References 73 publications

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“…[51] Cognitive decline, dementia, myopathy, and a rarer clinical condition involving epilepsy and cerebral calcifications in relation to CD have been described in case reports and series. [52][53][54][55] Several recent studies have evaluated the prevalence and clinical presentation of ataxia and peripheral neuropathy associated with CD, as well as the potentially gluten-dependent neurological conditions occurring in the absence of enteropathy. Gluten ataxia is considered a distinct disease process which can occur with or without enteropathy and is associated with high anti-gliadin antibody titers.…”

Section: Neurological Manifestationsmentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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Section: Neurological Manifestationsmentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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“…17 A special form of epilepsy with occipital calcifications is also linked to CD. 18 Association between CD and autoimmune disorders has drawn special attention. Type 1 diabetes mellitus (T1D), thyroid diseases, Sjögren's syndrome and other autoimmune diseases are overrepresented in CD and CD is overrepresented when patients with these disorders are serologically screened for CD.…”

Section: Box 1 Difficulties In Complex Inheritancementioning

confidence: 99%

Searching for genes influencing a complex disease: the case of coeliac disease

et al. 2007

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Recently, a few genes have been reported to be causative in inflammatory diseases. Still, we are waiting for the vast majority to be discovered. New tools for genotyping and statistical analysis have been developed and emphasis has been put on study design. Coeliac disease (CD) is a disorder, where prolamins in dietary wheat gluten and related proteins from rye or barley are not tolerated. It is one of the most common chronic diseases in humans exceeding a population prevalence of 1%. In this article, we will summarise what is currently known about the genetics influencing CD with the emphasis on the non-HLA genetic component. We will discuss some difficulties when searching for susceptibility genes in disorders with complex inheritance patterns.

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“…In the former group, depression and anxiety have been reported, 41 whereas in the latter there are a number of idiopathic neurological disorders, such as epilepsy with and without parieto-occipital calcifications, cerebellar ataxia, intellectual deterioration with attention/memory impairment, brain atrophy, peripheral neuropathy, multiplex myoclonus (Friedreich's disease) and multiple sclerosis. [42][43][44][45][46] Reproductive system dysfunction may be a sign of CD in both sexes. In females, there is a trend to late menarche, amenorrhea, early menopause and infertility, which respond positively to gluten withdrawal.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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Coeliac disease, epilepsy and cerebral calcifications

Cited by 104 publications

References 73 publications

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Searching for genes influencing a complex disease: the case of coeliac disease

Celiac disease: diagnostic criteria in progress

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