Coeliac disease hidden by cryptogenic hypertransaminasaemia in children: a case report

Hasbaoui, Brahim El; Mahi, Jihane El; Abilkassem, R.; Agadr, Aomar

doi:10.11604/pamj.2022.41.27.29084

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Numerous case reports have highlighted the harmful developmental consequences of maternal vitamin B12 de ciency caused by strict vegetarian or vegan diets without supplementation (e.g. [13][14][15] ). Vitamin B12 status can be assessed by methylmalonic acid (MMA) in urine, which accumulates in vitamin 12 de ciency [16].…”

Section: Introductionmentioning

confidence: 99%

Sanitary napkins are a valid urine collection tool to asses urinary iodine and methylmalonic acid

Delgas,

Bitsch,

Kriegler

et al. 2024

Preprint

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Introduction: Urinary biomarkers are invaluable for non-invasive assessment of nutrient status but urine collection can be cumbersome, especially in infants. Cotton fiber-based sanitary napkins offer a practical and cost-effective solution for urine collection, but could potentially interact with the urine and affect biomarker measurements. In this study, we aimed to validate whether urine extracted from sanitary napkins, can be used for urinary iodine and methylmalonic acid (MMA) analysis. Methods: We collected urine samples from volunteers following different dietary patterns (n = 30). Daily intake of iodine and vitamin B12 were estimated by food frequency questionnaire and supplement use was recorded. Samples were evaluated both in their native state and after adding them on sanitary napkins, with subsequent re-collection. Urinary iodine was analyzed by ICP-MS, MMA by LC-MS/MS and creatinine photometrically. To compare the agreement of measurement between native and processed samples, intraclass correlation coefficients (ICC) were calculated. Results: Daily estimated iodine intake varied from 57.8–216.5 µg/day and vitamin B12 from 1.2–685 µg/day yielding a broad range of urinary iodine: (5.60–151.3 µg/L) and MMA (0.70–2.37 mg/g creatinine). Native and processed urine showed an excellent agreement of measurement for iodine (ICC = 1.0), MMA (ICC = 0.99), creatinine (ICC = 0.99) as well as the ratio of MMA/ creatine (ICC = 0.95) with p < 0.001 for all, indicating no interaction between analytes and napkin. Conclusion: We demonstrate the validity of urine collection using sanitary napkins to measure urinary iodine, MMA and creatinine over a broad range of concentrations. Our approach is affordable and straightforward, and could streamline urine collection in large-scale studies.

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Section: Introductionmentioning

confidence: 99%

Sanitary napkins are a valid urine collection tool to asses urinary iodine and methylmalonic acid

Delgas,

Bitsch,

Kriegler

et al. 2024

Preprint

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“…Сведения о распространенности поражения печени при целиакии неоднородны. Согласно данным литературы, ГТ на момент постановки диагноза встречается у 11-27% взрослых пациентов и 15-57% детей с целиакией, в то время как аутоиммунные поражения печени встречаются лишь у 1-2% детей [10][11][12][13][14].…”

Section: Introductionunclassified

Liver damage in children and adolescents with newly diagnosed celiac disease: clinical and anamnestic, serological and morphological patterns

Cherkasova¹,

Klimov²,

Kuryaninova³

et al. 2023

Terapevticheskii arkhiv

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Hypertransaminasemia is a common extra-intestinal manifestation of celiac disease. Aim. To analyze the frequency of hypertransaminasemia, clinical and anamnestic, serological and morphological picture in children in the active period of celiac disease. Materials and methods. The study included 272 children with celiac disease aged from 8 months to 17 years. The patients were divided into two groups: the first children with hypertransaminasemia, the second without hypertransaminasemia. Results. Hypertransaminasemia was detected in 55.9% of children with celiac disease. The age of manifestation of the disease in the first group was 1.0 [0.5; 2.0] years, in the second group 1.9 [0.5; 4.0] years (p=0.0004). Children of the first group were diagnosed at 2.5 [1.7; 4.9] years, the second group at 4.9 [3.0; 10.8] years (p0.001). The duration of the latency period in children of the first and second groups was 1.4 [0.6; 3.1] years and 2.4 [0.9; 4.3] years, respectively (p=0.002). The average values of IgA anti-tTG antibodies in children of the analyzed groups did not differ, and the indicators of IgG anti-tTG antibodies in the first group were 1.6 (p=0.04) times higher. The level of EMA in children with hypertransaminasemia was 2 times higher than in children without hypertransaminasemia. Conclusion. Hypertransaminasemia is more often detected in young children with early manifestation of the disease, increases with the deepening of atrophy in the mucous membrane of the small intestine. Higher titers of celiac-specific antibodies were detected in children with hypertransaminasemia.

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Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients

Tamai

Ihara

2023

IJMS

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Celiac disease is an autoimmune disease primarily affecting the small intestine that is caused by the ingestion of gluten in genetically susceptible individuals. The development of celiac disease is based on a complex immune response to gluten proteins. The global average prevalence in the general population is about 1%. In recent years, it has become clear that celiac disease is not less common in Asian countries than in Western countries but often remains undiagnosed. Although the number of patients with celiac disease in Asia is expected to increase with improving disease recognition and advances in diagnostic techniques, there remain few reports of celiac disease in the Far East region of Asia, especially in Japan. In this paper, we outline the epidemiology, diagnosis, and treatment of celiac disease. In addition, we summarize the reported Japanese cases of celiac disease with an overview in Japan.

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Coeliac disease hidden by cryptogenic hypertransaminasaemia in children: a case report

Cited by 3 publications

References 9 publications

Sanitary napkins are a valid urine collection tool to asses urinary iodine and methylmalonic acid

Sanitary napkins are a valid urine collection tool to asses urinary iodine and methylmalonic acid

Liver damage in children and adolescents with newly diagnosed celiac disease: clinical and anamnestic, serological and morphological patterns

Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients

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