Coeliac disease in old age: 'a catch in the rye'

Beaumont, D; Mian, Masood S.

doi:10.1093/ageing/27.4.535

Cited by 16 publications

(9 citation statements)

References 25 publications

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“…14 But later studies showed that 19-34% of new cases of celiac disease are diagnosed in this age group. 11,15-18 Interestingly, a survey of 2,440 celiac patients in the United States reported that the proportion of celiac disease patients diagnosed in the elderly is similar to that of patients diagnosed before 18 years of age (16% versus 15%, respectively). 10 In accord with these studies, a population-based study of Olmsted County residents in Minnesota, reported that celiac disease incidence rates (new cases of celiac disease per 100,000 person-year) in people over 65 years of age increased significantly from 0.0 in 1950-1959 to 15.1 in 2000-2001.…”

Section: Epidemiologymentioning

confidence: 99%

Celiac Disease in the Elderly

Rashtak

Murray

2009

Gastroenterology Clinics of North America

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It has become recently apparent that celiac disease, though once thought to be a primarily childhood disease, can affect people of any age. Epidemiologic studies have suggested that a substantial portion of patients are diagnosed after the age of 50. Indeed, in one study, the median age at the diagnosis was just under the age of 50 with one-third of new patients diagnosed over the age of 65. The purpose of this review is to address the prevalence, clinical features, diagnosis and consequences of celiac disease in the elderly. We will also review management strategies for celiac disease and adjust these with emphasis on the particular nutritional and non-nutritional consequences or associations of celiac disease as they pertain to the elderly.

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Section: Epidemiologymentioning

confidence: 99%

Celiac Disease in the Elderly

Rashtak

Murray

2009

Gastroenterology Clinics of North America

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“…Individuals with normal body mass indexes were also had CD diagnosis. It was found that 25% of adult patients who had CD diagnosis were older than 60 years . The mean age of patients in this study's CD group was 34.9 ± 14 (19‐66).…”

Section: Discussionmentioning

confidence: 54%

“…It was found that 25% of adult patients who had CD diagnosis were older than 60 years. 12 The mean age of patients in this study's CD group was 34.9 ± 14 .…”

Section: Discussionmentioning

confidence: 80%

Comparison of non‐invasive tests with invasive tests in the diagnosis of celiac disease

Gülseren

Adiloğlu

Yücel

et al. 2018

Clinical Laboratory Analysis

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Background/Aims Today, invasive diagnostic tests are necessary for definite diagnosis of adult celiac disease (CD). However, in selected children patients, the need for invasive tests is ceased. In this study, we evaluated adult patients according to the ESPGHAN (European Pediatric Gastroenterology Hepatology and Nutrition Society) criteria. Methods Thirty‐nine patients (aged 17‐66) with symptoms of CD were included. Serum samples were tested for total IgA, tTG‐IgA (antitissue transglutaminase), tTG‐IgG, DGP‐IgA (antideamidated gliadin peptide), DGP‐IgG, and EMA (endomysial antibodies). HLA‐DQ typing was studied with PCR‐SSP (sequence‐specific primers) method. Biopsy samples were evaluated according to Marsh scoring. Results In CD patients, 71.4% (15/21) of the patients were diagnosed without biopsy according to the EPSGHAN criteria but when ESPGHAN's IgA tTG threshold value for children was taken into consideration (>200 IU/mL), the sensitivity decreased to 81%. Celiac disease diagnosed and control groups were compared in terms of HLA tissue types. DQ2.5 homozygous or DQ2.5/DQ2.2 was significantly higher in CD group, and DQ2‐ or DQ8‐negative HLA tissue type was significantly higher in control group. Conclusion When serological tests, HLA typing, and clinical symptoms are all in favor of CD, biopsy may not be performed in selected adult CD patients.

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“…The protocol does not describe the macroscopic appearance of the duodenum and ileum, but histological assessment documented subtotal villous atrophy, chronic inflammation, and crypt hyperplasia suggesting celiac disease. In 20–25 % of patients, celiac disease first manifests itself at the age of 60 years or older [ 4 ], so based on histology alone this diagnosis could indeed be made for this 82-year-old patient. Tests for celiac disease with antibodies to tissue transglutaminase and endomysium were, however, negative.…”

Section: Differential Diagnosismentioning

confidence: 99%