Coeliac disease in South Asians resident in Britain: comparison with white Caucasian coeliac patients

Butterworth, Jeffrey; Iqbal, Tariq; Cooper, Barrett R.

doi:10.1097/00042737-200505000-00011

Cited by 21 publications

(18 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the United States, a greater proportion of HLA DQ8 and a smaller proportion of DQ2 than in Europe have been reported. 9 HLA DQ2 and DQ8 frequencies similar to those observed in the USA have been described in Asian10, Cuban11 and Chilean12 populations.…”

Section: Introductionsupporting

confidence: 71%

“…Butterworth et al, in England, demonstrated that patients of Indian origin had lower frequency of HLA DQ2 than those of British origin 10. Lower frequencies of HLA DQ2 and higher frequency of HLA DQ8 than European have also been described among celiac disease patients in the United States (82% DQ2 and 16% DQ8 only) and in Cuba (86% DQ2) 11,17 …”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil

Antunes

Crovella

Brandão³

et al. 2011

Clinics

View full text Add to dashboard Cite

AIMS:The aim of this study was to evaluate the frequencies of the HLA genotypes DQ2 and DQ8 and the alleles A1*05, A1*0201, B1*0201 and B1*0302 in individuals with celiac disease in Recife, northeastern Brazil.METHODS:HLA DQ2 and DQ8 genotyping was performed for 73 individuals with celiac disease and 126 first-degree relatives with negative transglutaminase serology. The alleles DQA1*05, DQA1*0201, DQB1*02 and DQB1*0302 were identified by sequencing using specific primers and the EU-DQ kit from the Eurospital Laboratory, Trieste, Italy and double-checked by the All Set SPP kit (Dynal).RESULTS:Among the 73 cases, 50 (68.5%) had the genotype DQ2, 13 (17.8%) had DQ8, 5 (6.8%) had DQ2 and DQ8, and 5 did not have any of these genotypes. Among the 5 negative individuals, four had the B1*02 allele and one did not have any of the alleles studied. B1*02 was the most frequent allele in both groups (94% in the patients and 89% in the control relatives).CONCLUSIONS:In this study, celiac disease was associated with the genotypes DQ2 and DQ8. DQ2 predominated, but the distribution of the frequencies was different from what has been found in European populations and was closer to what has been found in the Americas. The high frequencies of the HLA genotypes DQ2 and DQ8 that were found in first-degree relatives would make it difficult to use these HLA genotypes for routine diagnosis of celiac disease in this group.

show abstract

Section: Introductionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 94%

Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil

Antunes

Crovella

Brandão³

et al. 2011

Clinics

View full text Add to dashboard Cite

show abstract

“…CD has been described in South Asian patients who had immigrated to Europe or to North America [29,30,31,32]. A recent Italian multicenter study on immigrant children with CD showed that 3 of the children that migrated to Italy were native to Pakistan and 1 to Sri Lanka [32].…”

Section: Celiac Disease In Asiamentioning

confidence: 99%

Celiac Disease Screening in Southern and East Asia

Makharia

2015

Dig Dis

View full text Add to dashboard Cite

Until 1970s, celiac disease (CD) was considered to be an uncommon disease except in Western Europe. The global epidemiology of CD continues to evolve with improvement in the diagnostic tests, simplification of the diagnostic criteria and increase in awareness about the disease. The Asian region is currently at the crossroads of the frontier of knowledge and awareness of CD. In many Asian nations, CD is still considered to be either nonexistent or very rare. A notable exception is India, where CD has been well recognized, especially in the northern part, and 2 population-based studies have revealed a prevalence of 0.3-1.04%. Initial reports from Malaysia, China, Japan and Singapore suggest the existence of CD in these countries. Furthermore, a meta-analysis of the predisposing factors predicts a high probability of occurrence of CD in fair numbers in China. There are no formal reports on CD from Malaysia, Indonesia, Korea, Taiwan and many other nations in this region. With the impending CD epidemic in Asia, there are many challenges. Some of the efforts which are required include determination of prevalence of CD across the region, spreading of awareness among physicians and patients, training of dieticians for proper counseling and supervision of patients, creation of gluten-free food infrastructure in the food supply and creation of patient advocacy organizations. Although the absolute number of patients with CD at present is not very large, this number is expected to increase over the next few years/decades. It is thus appropriate that the medical community across Asia define the extent of the problem and get prepared to handle the impending CD epidemic.

show abstract

“…It would be expected that coeliac disease might develop in these populations and their descendants when they move to other parts of the world where wheat is eaten, and this was observed almost 40 years ago in children of Asian immigrants to Britain11 12 and confirmed in adults in Britain13 14 and Canada 15…”

Section: Introductionmentioning

confidence: 96%