Coeliac Disease. Pathogenesis and clinical aspects

Friis, Stine

doi:10.1111/j.1600-0463.1996.tb05578.x

Cited by 4 publications

(3 citation statements)

References 211 publications

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“…Anti-gliadin and anti-reticulin antibodies have also been described in AE. 7 Patients with anti-goblet cell antibodies, in some instances, show absence or reduced numbers of goblet cells; Paneth cells can be reduced as well on intestinal biopsy specimens, illustrated in Figure 3, A and B. However, it should be borne in mind that anti-goblet cell antibodies are not specific for this disorder.…”

Section: Autoimmune Enteropathymentioning

confidence: 98%

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An Update on Celiac Disease Histopathology and the Road Ahead

Bao¹,

Green²,

Bhagat³

2012

Archives of Pathology &Amp; Laboratory Medicine

109

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Context.—Celiac disease (CD) is a common immune-mediated disorder that occurs in genetically predisposed individuals (carriers of HLA-DQ2 and DQ8 haplotypes) on consumption of wheat (gluten). It is characterized by inflammation of the small-intestinal mucosa and myriad gastrointestinal and systemic manifestations. Celiac disease is common in the general population (prevalence, 0.5%–1%). Currently, small-bowel biopsy is considered the gold standard for diagnosing CD. However, the role of serologic testing in the diagnosis of CD has evolved, from being a supportive test to supplanting intestinal biopsies in certain patient populations. Objective.—To summarize key aspects of histopathologic assessment, discuss the benefit of standardized pathology reports, impact of the site and number of small-bowel biopsy samples on diagnosis, and recommendations regarding serologic testing. Data Sources.—Literature review of publications on CD and experience with histopathologic review of biopsies at the Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York. Conclusions.—Intraepithelial lymphocytosis in the context of villous atrophy is considered a characteristic histologic finding of CD; however, it is a rather nonspecific finding. A growing list of publications has also indicated that the detection of intraepithelial lymphocytosis in the absence of villous atrophy has rather low specificity for CD. Therefore, communication between pathologists and gastroenterologists is paramount, as is knowledge regarding the pertinent clinical and laboratory data, in distinguishing between CD and other disorders with similar histopathologic and clinical manifestations.

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Section: Autoimmune Enteropathymentioning

confidence: 98%

“…The frequency of these alleles in the general populations in Western countries is 20% to 30%. [7][8][9] Therefore, an individual not carrying DQ2 or DQ8 alleles is extremely unlikely to develop CD. Among autoimmune disorders, CD is one of the remarkably few where the offending antigen is known, that is, gluten (component of wheat, barley, and rye).…”

mentioning

confidence: 99%

An Update on Celiac Disease Histopathology and the Road Ahead

Bao¹,

Green²,

Bhagat³

2012

Archives of Pathology &Amp; Laboratory Medicine

109

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“…In addition, recommended breads for the GF diet are often based on wheat starch, which in principle should be free from gluten or gliadin. As it is very difficult to remove gliadin completely, wheat starch usually contains trace amounts of allergenic protein (Friis 1996). Residual gliadin can exacerbate CD and cause persistent symptoms in treated patients.…”

mentioning

confidence: 99%

Application of Response Surface Methodology in the Development of Gluten‐Free Bread

et al. 2005

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Cereal Chem. 82(5):609-615The formulation of gluten-free (GF) bread of high quality presents a formidable challenge as it is the gluten fraction of flour that is responsible for an extensible dough with good gas-holding properties and baked bread with good crumb structure. As the use of wheat starch in GF formulations remains a controversial issue, naturally GF ingredients were utilized in this study. Response surface methodology was used to optimize a GF bread formulation primarily based on rice flour, potato starch, and skim milk powder. Hydroxypropylmethylcellulose (HPMC) and water were the predictor variables. Analyses of the treatments from the design were made 24 hr after baking. Specific volume and loaf height increased as water addition increased (P < 0.01). Crumb firmness decreased as water levels increased (P < 0.01). Significant interactions (P < 0.01) between HPMC and water were found for the number of cells/cm 2 . The number of large cells (>4 mm 2 ) decreased with increasing levels of HPMC and water. Optimal ingredient levels were determined from the data obtained. The optimized formulation contained 2.2% HPMC and 79% water flour/starch base (fsb) and measured responses compared favorably to predicted values. Shelf-life analysis of the optimized formulation over seven days revealed that, as crumb firmness increased, crust firmness and crumb moisture decreased. 2 Corresponding

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