Coeliac screening in a high-risk population: paediatric type 1 diabetes—a review of current guidelines and practice

Forde, Luke; McGrath, Niamh; Devaney, D.; Awadalla, Sami; McDonnell, Ciara M.; Murphy, Nuala

doi:10.1007/s11845-018-1831-0

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…In our study, CD was diagnosed in 7% of the patients with T1DM. This frequency is similar to the rates reported in previous studies (3,(5)(6)(7)(12)(13)(14). CD is diagnosed in patients at the time of T1DM diagnosis and usually within the first 5 years of follow-up (7,14,15).…”

Section: Discussionsupporting

confidence: 89%

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Tip 1 diyabetes mellitus tanılı çocuklarda çölyak hastalığı sıklığının araştırılması

Yıldız

2023

Jour Umraniye Pediatr

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Objective:The aim of this study is to determine the frequency of celiac disease (CD) in children with T1DM at the time of diabetes diagnosis and during follow-up, and to evaluate the effect of CD on growth and metabolic control in diabetic patients. Material and Methods: In this study, celiac autoantibody screening was performed at the time of diabetes diagnosis and during follow-up in 243 regularly followed-up patients who were diagnosed with T1DM between January 2007 and December 2018 at a university hospital and had a diabetes duration of at least 1 year. In serology-positive patients, the diagnosis of CD was confirmed by small bowel biopsy. The effects of CD and dietary compliance on growth and metabolic control were evaluated. Results:The mean age of the 243 patients (124 boys, 119 girls) at the time of the study was 12.3±4.9 years, the mean duration of diabetes was 4.4±2.6 years, and the mean age at T1DM diagnosis was 7.6±4.6 years. The average glycated hemoglobin level (HbA1c) of the patients when they were diagnosed with T1DM was 11.9±2.57%. The prevalence of CD in the patients was 7% (n=17), with 88% of the patients being diagnosed with diabetes at the time of diagnosis, and 12% diagnosed with CD during follow-up. Conclusion:In our study, the prevalence of celiac disease in patients with type 1 diabetes was found to be 7%, similar to previous studies. It was determined that the majority of diabetic patients with CD were diagnosed at the time of diabetes diagnosis, and a small number of patients were diagnosed in the first 4 years of follow-up. We found that CD negatively affects the metabolic control of diabetes, either directly or due to non-compliance with the gluten-free diet, but does not affect growth in children with diabetes.

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Section: Discussionsupporting

confidence: 89%

“…The co-occurrence of T1DM and CD may result in inadequate blood sugar regulation, poor metabolic control, frequent hypoglycemia attacks, short stature, delayed puberty, vitamin and mineral insufficiency, and a decrease in bone mineral density (7,8).…”

Section: Introductionmentioning

confidence: 99%

Tip 1 diyabetes mellitus tanılı çocuklarda çölyak hastalığı sıklığının araştırılması

Yıldız

2023

Jour Umraniye Pediatr

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“…However, extra-intestinal manifestations (short stature, iron deficiency anemia, or delayed puberty) and silent forms are more frequent. Recently published studies have shown that up to 71.4% of children with T1DM do not have gastrointestinal symptoms when CD-specific antibodies are detected [ 41 , 42 ]. International guidelines recommend CD screening at T1DM diagnosis and annually for five years [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Does a Gluten-Free Diet Affect BMI and Glycosylated Hemoglobin in Children and Adolescents with Type 1 Diabetes and Asymptomatic Celiac Disease? A Meta-Analysis and Systematic Review

et al. 2022

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Background: Children diagnosed with type 1 diabetes mellitus (T1DM) are more prone to having celiac disease (CD) than the normal population. Moreover, patients with this dual diagnosis who are also on a diabetic and gluten-free diet (GFD) risk faltering growth and uncontrolled blood glucose levels. This review aims to assess the efficacy and effectiveness of managing patients with T1DM screened for CD with GFD to prevent complications associated with these chronic pathologies in childhood and adulthood. Materials and Methods: We abided by the PRISMA guidelines in this meta-analysis and used multiple databases and search engines. We included case–control studies. The primary outcomes were changes in the standard deviation score, body mass index (SDS BMI), and glycosylated hemoglobin (HA1C) after being on a GFD for at least twelve months. Results: The pooled data from the six studies included showed that there was neither a statistically significant difference in the mean SDS BMI (−0.28 (95% CI −0.75, 0.42)) (p = 0.24) nor in the mean of HA1C (mean −0.07 (95% CI −0.44, 0.30)) (p = 0.36) for the same group. HDL cholesterol improved significantly in patients on a strict GFD (p < 0.01). Conclusions: In children with T1DM and asymptomatic CD, being on a GFD had no significant effect on BMI or HA1C. However, it can have a protective effect on the other complications found in both chronic pathologies.

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“…The close association between CD and T1DM has been known for more than 50 years, and, generally, this marked tendency has led to two manifestations found to co-occur in 5-15% of CD patients [40]. This relationship may be because both diseases partially share the same genetic basis, and the DQ2/DR3 haplotypes are frequently present in the CD/T1DM patients [41], although both diseases are polygenic and have a greater susceptibility in several common loci, distributed over different chromosomes.…”

Section: Type 1 Diabetes Mellitus (T1dm)mentioning

confidence: 99%

Celiac Disease and Associated Extraintestinal Manifestations, with Special Reference to Neurological Disorders

Rodrigo¹

2020

OBM Neurobiology

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Celiac disease (CD), also known as gluten-sensitive enteropathy and nontropical sprue, is one of the most important entities of the wide spectrum of gluten-related disorders (GRDs). It is well known that neurological manifestations can be present either at the onset of CD, or appear during the development of the pathology, and the neurologic findings can show a profound difference. Clinical features show significant variation, ranging from typical manifestations of gastrointestinal involvement to several extraintestinal diseases. The most frequent neurologic signs reported are headaches, epileptic seizures, and migraines. Polyneuritis and the cerebellar ataxias have shown the most frequent association in adults. Headache either in the form of migraine or in nonspecific form represents one of the main clinical presentations in CD. This work aims to provide a narrative review of the current state of CD, highlighting the main extraintestinal disorders associated with CD. Complete compliance to a gluten-free diet (GFD) seems to improve the neurological symptoms even though the underlying pathogenic relationship between CD and the neurologic system remains poorly understood.

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Coeliac screening in a high-risk population: paediatric type 1 diabetes—a review of current guidelines and practice

Cited by 6 publications

References 24 publications

Tip 1 diyabetes mellitus tanılı çocuklarda çölyak hastalığı sıklığının araştırılması

Tip 1 diyabetes mellitus tanılı çocuklarda çölyak hastalığı sıklığının araştırılması

Does a Gluten-Free Diet Affect BMI and Glycosylated Hemoglobin in Children and Adolescents with Type 1 Diabetes and Asymptomatic Celiac Disease? A Meta-Analysis and Systematic Review

Celiac Disease and Associated Extraintestinal Manifestations, with Special Reference to Neurological Disorders

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