Coenzyme Q10 in the treatment of hypertension: a meta_analysis of the clinical trials

Rosenfeldt, F.L.; Haas, SJ; Krum, Henry; Hadj, Anthony; Ng, Kelvin; Leong, J_Y; Watts, G.F.

doi:10.1016/j.yjmcc.2007.03.902

Cited by 6 publications

(6 citation statements)

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“…Meta-analysis has demonstrated that coenzyme Q 10 has favorable effects on blood pressure in hypertensive patients without significant side effects. 24 Coenzyme Q 10 has been suggested to possess an antifatigue effect. [25][26][27] Recently Mizuno et al 27 demonstrated that a short course of coenzyme Q 10 (100 or 300 mg=day for 8 days) improved subjective fatigue after a fatigue-inducing physical task.…”

Section: Discussionmentioning

confidence: 99%

Effects of Coenzyme Q₁₀ on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study

Lee

Cho

Kim

et al. 2011

Journal of Medicinal Food

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This study investigated the effects of coenzyme Q(10) supplementation on metabolic parameters, inflammatory markers, arterial stiffness, and fatigue in obese subjects. We performed a randomized, double-blind, placebo-controlled, single-center study on 51 obese subjects with a body mass index (BMI) of ≥25 kg/m(2). Subjects were randomized into either a coenzyme Q(10) (200 mg/day) group (n = 26, BMI = 27.9 ± 2.3 kg/m(2), age = 42.7 ± 11.3 years) or a placebo group (n = 25, BMI = 26.8 ± 2.8 kg/m(2), age = 41.3 ± 11.2 years) for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, brachial-ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness, and responses to a fatigue severity scale (FSS) questionnaire at the initial (0 week) and final (12 weeks) visits. A total of 36 subjects successfully completed the study protocol. Serum coenzyme Q(10) levels increased significantly from 0.65 ± 0.27 μg/mL to 1.20 ± 0.38 μg/mL in the coenzyme Q(10) group (P < .001). Oral administration of coenzyme Q(10) did not significantly affect lipid profiles, oxidative and inflammatory markers [including lipoprotein (a), oxidized low-density lipoprotein level, C-reactive protein, and white blood cell count], or baPWV. The mean FSS score decreased significantly from 40.1 to 33.1 in the coenzyme Q(10) group (P = .017), but no significant change was seen in the placebo group (P = .464). However, the extents of the change in mean FSS score between the placebo and coenzyme Q(10) groups were not significantly different (P = .287). In conclusion, we found no evidence that coenzyme Q(10) affects fatigue index, arterial stiffness, metabolic parameters, or inflammatory markers.

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Section: Discussionmentioning

confidence: 99%

Effects of Coenzyme Q₁₀ on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study

Lee

Cho

Kim

et al. 2011

Journal of Medicinal Food

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“…The linear range was as follows: 0.09-10.0 mg/L for retinol and ␥-tocopherol, 0.93-100 mg/L for ␣-tocopherol, 0.05-5 mg/L for ␤-carotene and 0.14-15 mg/L for CoQ 10 . These calibration ranges cover the 95% reference interval for all analytes.…”

Section: Linearity and Limits Of Detection And Quantitationmentioning

confidence: 96%

“…been linked with prevention of serious diseases, e.g., cardiovascular, eye diseases, atherosclerosis, bone calcification, neurological disorders (e.g., Parkinson's and Alzheimer's), cancer, cataracts and improving child growth [1][2][3][4][5][6][7][8][9]. Supplementation with coenzyme Q 10 has been studied for its effect on hypertension [10,11], some neurodegenerative diseases [12], in reducing migraine headaches [13], as a possible marker of oxidative stress [14] and increased risk of atherosclerosis [15]. Direct measurement of the serum concentration of these important vitamins is essential for the evaluation of nutritional status of a patient.…”

Section: Introductionmentioning

confidence: 99%

Rapid quantitative determination of fat-soluble vitamins and coenzyme Q-10 in human serum by reversed phase ultra-high pressure liquid chromatography with UV detection

Paliakov

Crow

Bishop

et al. 2009

Journal of Chromatography B

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“…[8][9][10] It has also been reported that CoQ 10 has a hypotensive effect. 7,11,12) In addition, a number of people who usually intake CoQ 10 as a supplement also receive some kinds of drugs to treat high blood pressure. Therefore, on the basis of the health-oriented tendency in the market, where a large number of CoQ 10 supplements including a relatively high dose of CoQ 10 are available, the presence of pharmacokinetic (PK) and pharmacodynamic (PD) interactions between CoQ 10 and drugs for medical use is suspected.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

Nishimura

Fujimura

Hasegawa

et al. 2010

JOURNAL OF HEALTH SCIENCE

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We examined pharmacokinetic (PK) and pharmacodynamic (PD) interactions between coenzyme Q 10 (CoQ 10 ) and nifedipine (NFP), which is a popular medicine for treating hypertension, and elucidated possible mechanisms for the interaction between CoQ 10 and NFP in rats. The mean plasma concentrations of NFP in rats after the oral administration of NFP (1 mg/kg) with CoQ 10 (75 mg/kg) were increased over the study period and the area under the plasma concentration-time curve (AUC), showed a 1.47-fold increase compared with that of the control. Rats that received NFP with CoQ 10 showed a continuous decrease in the mean blood pressure over the study period compared with the control. There were no significant changes in the PK parameters of NFP after intravenous administration (1 mg/kg) between with and without oral CoQ 10 pretreatment, and also no significant changes in the intestinal excretion of rhodamine 123 (Rho123) or NFP between with and without CoQ 10 were found. In contrast, the portal plasma concentration of NFP after intra loop administration in the presence of CoQ 10 (75 mg/kg) showed a 1.6-fold increase in the AUC value compared with that of the control. As for physicochemical properties, the partition coefficient of NFP showed a marked increase in the presence of CoQ 10 over 10 mg/ml in the organic phase (n-hexane). From on an analysis of the absorbance spectrum, CoQ 10 showed a shift towards a longer wavelength in hydrophobic environments with NFP, suggesting that CoQ 10 reacts with NFP to form a charge-transfer complex due to a pi-cloud between them. In conclusion, it was found that CoQ 10 increases the oral bioavailability of NFP and that this interaction between NFP and CoQ 10 is not caused by metabolism via cycochrome P450 (CYP) 3A in the liver or intestine or by the inhibition of P-glycoprotein function, by the physicochemical interaction between them. Therefore, the solubility of NFP in a hydrophobic environment could be enhanced by forming a chargetransfer complex with CoQ 10 , and it is considered that NFP deviating from a charge-transfer complex may migrate to the blood circulation from the intestinal tract. This mechanism of interaction is considered a new type of drugsupplement interaction.

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Coenzyme Q10 in the treatment of hypertension: a meta_analysis of the clinical trials

Cited by 6 publications

References 0 publications

Effects of Coenzyme Q₁₀ on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study

Effects of Coenzyme Q₁₀ on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study

Rapid quantitative determination of fat-soluble vitamins and coenzyme Q-10 in human serum by reversed phase ultra-high pressure liquid chromatography with UV detection

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

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Coenzyme Q10 in the treatment of hypertension: a meta_analysis of the clinical trials

Cited by 6 publications

References 0 publications

Effects of Coenzyme Q10 on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study

Effects of Coenzyme Q10 on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study

Rapid quantitative determination of fat-soluble vitamins and coenzyme Q-10 in human serum by reversed phase ultra-high pressure liquid chromatography with UV detection

Pharmacokinetic Interaction between Nifedipine and Coenzyme Q10 in Rats: A New Type of Drug-Supplement Interaction

Contact Info

Product

Resources

About

Effects of Coenzyme Q₁₀ on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study

Effects of Coenzyme Q₁₀ on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study