Coenzyme Q10 protects against doxorubicin-induced cardiomyopathy via antioxidant and anti-apoptotic pathway

Shabaan, Dalia A.; Mostafa, Nora; El-Desoky, Manal M.; Arafat, Eetmad A.

doi:10.1080/21688370.2021.2019504

Cited by 11 publications

(5 citation statements)

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“…The clinical use of DOX, as one of the most effective agents prescribed against various tumors, is limited due to its serious cardiac side effects. Evidence strongly recommends applying dietary antioxidants, especially of natural origin, as a worthwhile tool in the preservation of heart function and structure after DOX therapy [ 2 , 18 ]. The wide distribution of G. verum , its use in traditional medicine, and its confirmed antioxidant effects make it favorable for examination as an adjuvant in the management of DOX-induced cardiotoxic effects.…”

Section: Discussionmentioning

confidence: 99%

Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

et al. 2023

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This study aimed to examine the effects of a 14-day treatment with lady’s bedstraw methanol extract on doxorubicin-induced cardiotoxicity through functional, biochemical and histological examinations. We used 24 male Wistar albino rats divided into the following groups: control (CTRL), doxorubicin (DOX), and DOX + GVE (Galium verum extract). GVE was administered orally at a dose of 50 mg/kg per day for 14 days, while a single dose of doxorubicin was injected into the DOX groups. After accomplishing treatment with GVE, cardiac function was assessed, which determined the redox state. During the autoregulation protocol on the Langendorff apparatus, ex vivo cardiodynamic parameters were measured. Our results demonstrated that the consumption of GVE effectively suppressed the disturbed response of the heart to changes in perfusion pressures caused by administration of DOX. Intake of GVE was associated with a reduction in most of the measured prooxidants in comparison to the DOX group. Moreover, this extract was capable of increasing the activity of the antioxidant defense system. Morphometric analyses showed that rat hearts treated with DOX showed more pronounced degenerative changes and necrosis compared to the CTRL group. However, GVE pretreatment seems to be able to prevent the pathological injuries caused by DOX injection via decrease in oxidative stress and apoptosis.

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Section: Discussionmentioning

confidence: 99%

Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

et al. 2023

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“… 57 Furthermore, CoQ 10 has been demonstrated to mitigate apoptosis in several disorders, potentially through its antioxidant properties, anti-apoptotic effects, and its ability to alleviate mitochondrial dysfunction. 58 …”

Section: Discussionmentioning

confidence: 99%

“…Previous research has indicated that CoQ 10 is implicated in the up-regulation of anti-apoptotic agents, such as Bclxl, Bcl-2, 59 and survivin, along with the down-regulation of proapoptotic agents including Bax, Bid, and Fas. 58 CoQ 10 also elevated the expression of survival proteins, thereby promoting cell survival through its effective antioxidant properties. 60 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of the protective effect of coenzyme Q₁₀ on hepatotoxicity caused by acute phosphine poisoning

Hooshangi Shayesteh,

Hami,

Chamanara

et al. 2024

Int J Immunopathol Pharmacol

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Background: Aluminum phosphide (AlP) poisoning is prevalent in numerous countries, resulting in high mortality rates. Phosphine gas, the primary agent responsible for AlP poisoning, exerts detrimental effects on various organs, notably the heart, liver and kidneys. Numerous studies have documented the advantageous impact of Coenzyme Q10 (CoQ10) in mitigating hepatic injuries. The objective of this investigation is to explore the potential protective efficacy of CoQ10 against hepatic toxicity arising from AlP poisoning. Method: The study encompassed distinct groups receiving almond oil, normal saline, exclusive CoQ10 (at a dosage of 100 mg/kg), AlP at 12 mg/kg; LD50 (lethal dose for 50%), and four groups subjected to AlP along with CoQ10 administration (post-AlP gavage). CoQ10 was administered at 10, 50, and 100 mg/kg doses via Intraparietal (ip) injections. After 24 h, liver tissue specimens were scrutinized for mitochondrial complex activities, oxidative stress parameters, and apoptosis as well as biomarkers such as aspartate transaminase (AST) and alanine transaminase (ALT). Results: AlP induced a significant decrease in the activity of mitochondrial complexes I and IV, as well as a reduction in catalase activity, Ferric Reducing Antioxidant Power (FRAP), and Thiol levels. Additionally, AlP significantly elevated oxidative stress levels, indicated by elevated reactive oxygen species (ROS) production, and resulted in the increment of hepatic biomarkers such as AST and ALT. Administration of CoQ10 led to a substantial improvement in the aforementioned biochemical markers. Furthermore, phosphine exposure resulted in a significant reduction in viable hepatocytes and an increase in apoptosis. Co-treatment with CoQ10 exhibited a dose-dependent reversal of these observed alterations. Conclusion: CoQ10 preserved mitochondrial function, consequently mitigating oxidative damage. This preventive action impeded the progression of heart cells toward apoptosis.

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“…These findings agreed with the study Chen et al; 34 therefore, CoQ10 may prevent heart damage caused by doxorubicin and protect cardiomyocytes from fibrosis and cell death. In addition, Shabaan et al, 35 concluded that by modulating the expression of genes, CoQ10 protects against DOX-induced cardiotoxicity. The administration of CoQ10 in conjunction with DOX results in an increase in the Bax/Bcl-2 gene expression ratio, caspase-3 and iNOS immunoexpression, and MDA levels.…”

Section: Discussionmentioning

confidence: 99%

Evaluate The Effect of Coenzyme Q10 on The Prevention of Doxorubicin-Induced Acute Cardiotoxicity in Rats.

AL-Shimaysawee,

Fadhil Abd aljabbar Rizij,

Rafid Mohammed Ali Hassan wasfi

2024

J. Contemp. Med. Sci.

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Objective: This study will evaluate the potential protective effects of coenzyme Q10 on DOX-induced cardiotoxicity in female rats, manifested by changes in biochemical parameters in tissue and serum samples histopathological differences, and compare their changes. Methods:24 female rats were divided into three groups based on weight. The first group received saline, the second group received a cumulative dose of 15 mg/kg of DOX via IP injection, and the third group was pre-treated with CoQ10 before receiving DOX. The data were analysed using a one-way ANOVA test with a Bonferroni post hoc test to compare the markers and histopathological changes in different groups. The GraphPad Prism version 8.1 was used to do the statistical analysis. Results: As indicated by a statistically significant increase (P<0.0001) in TNFα and ICAM-1 level, doxorubicin-induced cardiotoxicity. Additionally, the level of GSH, SOD, and caspase-3 did not differ significantly between the DOX+CoQ10 group and the control group. Furthermore, lesions and histological alterations were induced by the substance. Significant reductions in cardiotoxicity were observed with the administration of coenzyme Q10, as indicated by notable increases (P<0.0001) in SOD, GSH, and TNFα and significant decreases (P<0.0001) in caspase 3 when compared to the DOX group. Also, the CMYO score and lesions exhibited a substantial improvement. Conclusion: In this investigation, coenzyme Q10 exhibited cardioprotective effects against DOX-induced damage to the mouse heart. This phenomenon potentially pertains to inhibiting and safeguarding against oxidative stress, the pathway of apoptosis, and the inflammatory response.

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Coenzyme Q10 protects against doxorubicin-induced cardiomyopathy via antioxidant and anti-apoptotic pathway

Cited by 11 publications

References 53 publications

Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

Evaluation of the protective effect of coenzyme Q₁₀ on hepatotoxicity caused by acute phosphine poisoning

Evaluate The Effect of Coenzyme Q10 on The Prevention of Doxorubicin-Induced Acute Cardiotoxicity in Rats.

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Coenzyme Q10 protects against doxorubicin-induced cardiomyopathy via antioxidant and anti-apoptotic pathway

Cited by 11 publications

References 53 publications

Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

Evaluation of the protective effect of coenzyme Q10 on hepatotoxicity caused by acute phosphine poisoning

Evaluate The Effect of Coenzyme Q10 on The Prevention of Doxorubicin-Induced Acute Cardiotoxicity in Rats.

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Evaluation of the protective effect of coenzyme Q₁₀ on hepatotoxicity caused by acute phosphine poisoning