Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients <i>via</i> reducing brain activity and mitochondrial dysfunction

Sawaddiruk, Passakorn; Apaijai, Nattayaporn; Paiboonworachat, Sahattaya; Kaewchur, Tawika; Kasitanon, Nuntana; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Chattipakorn, Nipon; Chattipakorn, Siriporn C.

doi:10.1080/10715762.2019.1645955

Cited by 45 publications

(33 citation statements)

References 22 publications

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“…A summary of the PET studies used in the present systematic review is presented in Supplementary Table 4 . Patients with FM (Walitt et al, 2007 ; Harris et al, 2009 ; Boyer et al, 2014 ; Sawaddiruk et al, 2019 ), IBS (Berman et al, 2002 ; Mayer et al, 2002 ; Lieberman et al, 2004 ; Lackner et al, 2006 ) ( n = 4), neuropathic pain (Maarrawi et al, 2007 ; Kishima et al, 2010 ; Yoon et al, 2014 ) ( n = 3), headache (Magis et al, 2011 ), and chronic tennis elbow (Linnman et al, 2016 ) ( n = 1) were included in the PET imaging studies. To treat chronic pain patients, neurostimulation (occipital nerve, spinal cord, tDCS/TMS, etc.…”

Section: Resultsmentioning

confidence: 99%

Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies

et al. 2021

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Previous studies have identified altered brain changes in chronic pain patients, however, it remains unclear whether these changes are reversible. We summarized the neural and molecular changes in patients with chronic pain and employed a meta-analysis approach to quantify the changes. We included 75 studies and 11 of these 75 studies were included in the activation likelihood estimation (ALE) analysis. In the 62 functional magnetic resonance imaging (fMRI) studies, the primary somatosensory and motor cortex (SI and MI), thalamus, insula, and anterior cingulate cortex (ACC) showed significantly decreased activity after the treatments compared to baseline. In the 13 positron emission tomography (PET) studies, the SI, MI, thalamus, and insula showed significantly increased glucose uptake, blood flow, and opioid-receptor binding potentials after the treatments compared to baseline. A meta-analysis of fMRI studies in patients with chronic pain, during pain-related tasks, showed a significant deactivation likelihood cluster in the left medial posterior thalamus. Further studies are warranted to understand brain reorganization in patients with chronic pain compared to the normal state, in terms of its relationship with symptom reduction and baseline conditions.

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Section: Resultsmentioning

confidence: 99%

Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies

et al. 2021

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“…For instance, the significant efficacy of coenzyme Q10 in the treatment of cardiac failure has been reported 21 . And preclinical researches have demonstrated the potential mechanistic and physiological benefits of coenzyme Q10 treatment, including improving of cardiac endothelial function, 21 reducing inflammatory burden, 25 decreasing left ventricle dysfunction 26 . It has also been reported that coenzyme Q10 deficiency is related to cancer development, and coenzyme Q10 could be used to prevent the incidence of cancer and improve the cancer prognosis 27 …”

Section: Discussionmentioning

confidence: 99%

Implication of nuclear factor‐erythroid 2‐like 2/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model

Zhou

et al. 2020

Microcirculation

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Background: Preeclampsia has ranked as one of the leading causes of both maternal and prenatal morbidity and mortality around the world. The hypotensive effect of coenzyme Q10 has been widely reported in preeclampsia rat model. However, the detailed mechanism remains unclear. Methods: L-NAME was utilized to establish the preeclampsia rat model. Biomarker assessments were performed to identify the levels of vascular factors including soluble fms-like tyrosine kinase (sFlt-1) and placental growth factor (PlGF), the circulating cytokines including interleukin 6, tumor necrosis factor α and interleukin 1β, and oxidative stress factors including malondialdehyde, H 2 O 2 , glutathione, superoxide dismutase, glutathione peroxidase, and Catalase. QRT-PCR was used to demonstrate the levels of cytokines in placenta tissues, and Western blot was performed to estimate the nuclear factor-erythroid 2-like 2 (Nrf2) and heme oxygenase 1 (HO-1) protein levels. Results: Coenzyme Q10 treatment decreased the blood pressure in rat model with preeclampsia by regulating the circulating levels of sFlt-1 and PlGF. Coenzyme Q10 attenuated serum and placental inflammation and oxidative stress in L-NAME-induced preeclampsia rats. Coenzyme Q10 activated the placental Nrf2/HO-1 pathway in L-NAME-induced preeclampsia rats. Conclusion: Coenzyme Q10 attenuated placental inflammatory and oxidative stress, thereby protecting the rats against preeclampsia by activating the Nrf2/HO-1 pathway.

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“…CoQ10 increased a reduced glutathione and SOD levels in patients with pregabalin-treated fibromyalgia. The supplementation of CoQ10 effectively reduced pain sensation, anxiety and brain activity, mitochondrial oxidative stress, and inflammation [ 120 ].…”

Section: Role Of Antioxidants In the Brainmentioning

confidence: 99%

Neuroprotective Effect of Antioxidants in the Brain

Lee

Cha

2020

IJMS

281

154

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The brain is vulnerable to excessive oxidative insults because of its abundant lipid content, high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) increase susceptibility to neuronal damage and functional deficits, via oxidative changes in the brain in neurodegenerative diseases. Overabundance and abnormal levels of ROS and/or overload of metals are regulated by cellular defense mechanisms, intracellular signaling, and physiological functions of antioxidants in the brain. Single and/or complex antioxidant compounds targeting oxidative stress, redox metals, and neuronal cell death have been evaluated in multiple preclinical and clinical trials as a complementary therapeutic strategy for combating oxidative stress associated with neurodegenerative diseases. Herein, we present a general analysis and overview of various antioxidants and suggest potential courses of antioxidant treatments for the neuroprotection of the brain from oxidative injury. This review focuses on enzymatic and non-enzymatic antioxidant mechanisms in the brain and examines the relative advantages and methodological concerns when assessing antioxidant compounds for the treatment of neurodegenerative disorders.

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Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction

Cited by 45 publications

References 22 publications

Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies

Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies

Implication of nuclear factor‐erythroid 2‐like 2/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model

Neuroprotective Effect of Antioxidants in the Brain

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