Coenzyme Q10 Supplementation in Fibrosis and Aging

Hargreaves, Iain P.; Mantle, David

doi:10.1007/978-3-030-25650-0_6

Cited by 31 publications

(19 citation statements)

References 33 publications

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“…The authors suggested that CoQ10 deficiency may contribute to the pathogenesis of MSA, and that increasing CoQ10 levels by supplementation or upregulation of its biosynthesis may represent a novel treatment strategy for MSA patients. Analogous conclusions were provided by Shimizu et al [ 31 ], and by Hargreaves and Mantle [ 32 ] that focused on the potential role of CoQ10 supplementation in the treatment of tissue fibrosis and cardiovascular risk, by improving cardiovascular function and reducing the risk of cardiovascular-associated mortality.…”

Section: Biochemical Principles and Prospects For The Use Of Mitocsupporting

confidence: 63%

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Pagano

Pallardó

Lyakhovich

et al. 2020

IJMS

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A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential–and distinct—roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs.

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Section: Biochemical Principles and Prospects For The Use Of Mitocsupporting

confidence: 63%

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Pagano

Pallardó

Lyakhovich

et al. 2020

IJMS

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“…5,6 Coenzyme Q10 is a crucial molecule in the MRC and participates in the electron transportation between complex I/II and complex III in the inner membrane of the mitochondria. 7 The abnormal alteration of coenzyme Q10 leads to the breakdown of oxidative phosphorylation and increased generation of ROS. 8 It has been revealed that exogenous coenzyme Q10 and its analogues function as important agents to alleviate the MRC disorder.…”

Section: Introductionmentioning

confidence: 99%

Implication of nuclear factor‐erythroid 2‐like 2/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model

Zhou

et al. 2020

Microcirculation

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Background: Preeclampsia has ranked as one of the leading causes of both maternal and prenatal morbidity and mortality around the world. The hypotensive effect of coenzyme Q10 has been widely reported in preeclampsia rat model. However, the detailed mechanism remains unclear. Methods: L-NAME was utilized to establish the preeclampsia rat model. Biomarker assessments were performed to identify the levels of vascular factors including soluble fms-like tyrosine kinase (sFlt-1) and placental growth factor (PlGF), the circulating cytokines including interleukin 6, tumor necrosis factor α and interleukin 1β, and oxidative stress factors including malondialdehyde, H 2 O 2 , glutathione, superoxide dismutase, glutathione peroxidase, and Catalase. QRT-PCR was used to demonstrate the levels of cytokines in placenta tissues, and Western blot was performed to estimate the nuclear factor-erythroid 2-like 2 (Nrf2) and heme oxygenase 1 (HO-1) protein levels. Results: Coenzyme Q10 treatment decreased the blood pressure in rat model with preeclampsia by regulating the circulating levels of sFlt-1 and PlGF. Coenzyme Q10 attenuated serum and placental inflammation and oxidative stress in L-NAME-induced preeclampsia rats. Coenzyme Q10 activated the placental Nrf2/HO-1 pathway in L-NAME-induced preeclampsia rats. Conclusion: Coenzyme Q10 attenuated placental inflammatory and oxidative stress, thereby protecting the rats against preeclampsia by activating the Nrf2/HO-1 pathway.

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“…Q-10 coenzyme, known by its oxidized form ubiquinone or the reduced one ubiquinol, also styled as CoQ 10 [ 131 ], plays a crucial role in protecting the cell membrane from lipidic peroxidation [ 132 ]. The very relevant part it takes in the ETC was previously aforementioned in this article.…”

Section: Antioxidantsmentioning

confidence: 99%

“…Antioxidants interact in more than one way; as a case in point, CoQ10 plays an important role in maintaining vitamin C and E in their full active reduced forms [ 131 ]. If a key antioxidant is missing it may disrupt other’s normal function; for instance, a clinical trial involving carnitine supplementation improved sperm parameters only in patients with normal GPX levels.…”

Section: Antioxidantsmentioning

confidence: 99%

Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress

Torres-Arce

Vizmanos

Babió

et al. 2021

Biology

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Infertility affects about 15% of the population and male factors only are responsible for ~25–30% of cases of infertility. Currently, the etiology of suboptimal semen quality is poorly understood, and many environmental and genetic factors, including oxidative stress, have been implicated. Oxidative stress is an imbalance between the production of free radicals, or reactive oxygen species (ROS), and the capacity of the body to counteract their harmful effects through neutralization by antioxidants. The purpose of this review, by employing the joint expertise of international researchers specialized in nutrition and male fertility areas, is to update the knowledge about the reproductive consequences of excessive ROS concentrations and oxidative stress on the semen quality and Assisted Reproduction Techniques (ART) clinical outcomes, to discuss the role of antioxidants in fertility outcomes, and finally to discuss why foods and dietary patterns are more innocuous long term solution for ameliorating oxidative stress and therefore semen quality results and ART fertility outcomes. Since this is a narrative review and not a systematic/meta-analysis, the summarized information in the present study should be considered cautiously.

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Coenzyme Q10 Supplementation in Fibrosis and Aging

Cited by 31 publications

References 33 publications

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Implication of nuclear factor‐erythroid 2‐like 2/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model

Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress

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