Coenzyme Q10 supplementation in non-alcoholic fatty liver disease: an overview

Mantle, David; Hargreaves, Iain P.

doi:10.12968/gasn.2020.18.2.22

Cited by 4 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of synthetic antioxidant compounds, small molecules with drug-like properties, has boomed in recent years. New benzoquinone-based antioxidants such as Mitoubiquinone (MitoQ), vatiquinone and idebenone have been developed and are included in several clinical trials for the treatment of liver disorders [275]. Another newly-designed synthetic drug with antioxidant capacity is despramipexole, a benzothiazole renowned for its effects on preserving mitochondrial function [276].…”

Section: Antioxidant Therapiesmentioning

confidence: 99%

Role of Oxidative Stress in Liver Disorders

Rosa

Goicoechea

Torres

et al. 2022

Livers

View full text Add to dashboard Cite

Oxygen is vital for life as it is required for many different enzymatic reactions involved in intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption in the electron transport chain of mitochondria is used to drive the synthesis of ATP to meet the energetic demands of cells. However, toxic free radicals are generated as byproducts of molecular oxygen consumption. Oxidative stress ensues not only when the production of reactive oxygen species (ROS) exceeds the endogenous antioxidant defense mechanism of cells, but it can also occur as a consequence of an unbalance between antioxidant strategies. Given the important role of hepatocytes in the biotransformation and metabolism of xenobiotics, ROS production represents a critical event in liver physiology, and increasing evidence suggests that oxidative stress contributes to the development of many liver diseases. The present review, which is part of the special issue “Oxidant stress in Liver Diseases”, aims to provide an overview of the sources and targets of ROS in different liver diseases and highlights the pivotal role of oxidative stress in cell death. In addition, current antioxidant therapies as treatment options for such disorders and their limitations for future trial design are discussed.

show abstract

Section: Antioxidant Therapiesmentioning

confidence: 99%

Role of Oxidative Stress in Liver Disorders

Rosa

Goicoechea

Torres

et al. 2022

Livers

View full text Add to dashboard Cite

show abstract

“…Administration of supplemental CoQ10 has been shown (on the basis of randomized controlled clinical trials) to benefit a number of disorders, especially the prevention [ 92 ] or treatment [ 93 ] of cardiovascular disease, but also diabetes [ 94 ], non-alcoholic fatty liver disease [ 95 ], and chronic kidney disease [ 96 ], as well as some neurological disorders [ 97 ]. In particular, the use of supplemental CoQ10 for the treatment of heart failure has become well-established based on such evidence.…”

Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 and Immune Function: An Overview

2021

Self Cite

View full text Add to dashboard Cite

Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning of the immune system. These include its essential role as an electron carrier in the mitochondrial respiratory chain, enabling the process of oxidative phosphorylation to occur with the concomitant production of ATP, together with its role as a potential lipid-soluble antioxidant, protecting the cell against free radical-induced oxidation. Furthermore, CoQ10 has also been reported to have an anti-inflammatory role via its ability to repress inflammatory gene expression. Recently, CoQ10 has also been reported to play an important function within the lysosome, an organelle central to the immune response. In view of the differing roles CoQ10 plays in the immune system, together with the reported ability of CoQ10 supplementation to improve the functioning of this system, the aim of this article is to review the current literature available on both the role of CoQ10 in human immune function and the effect of CoQ10 supplementation on this system.

show abstract

“…With regard to liver disease, blood CoQ10 levels are reportedly depleted in non-alcoholic fatty liver disease (NAFLD) patients, with the decrease in CoQ10 status correlating with increased liver inflammation and cirrhosis [9]. Randomised controlled trials found that supplementation with CoQ10 (100 mg/day for 1-3 months) resulted in significantly decreased systemic levels of biochemical markers of liver damage, inflammation and oxidative stress (aspartate aminotransferase, gamma-glutamyl peptidase, C-reactive protein) as reviewed by Mantle & Hargreaves [9].…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Mantle¹,

Turton²,

Hargreaves³

2022

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

Coenzyme Q10 (CoQ10) deficiency is broadly divided into two types, primary and secondary. Primary CoQ10 deficiencies are relatively rare disorders resulting from mutations in genes directly involved in the CoQ10 biosynthetic pathway, and are not a subject of this article. Secondary CoQ10 disorders are relatively common, and may occur for a variety of reasons; these include mutations in genes not directly related to the synthetic pathway, oxidative stress induced reduction of CoQ10, and the effects of pharmacological agents such as statins. CoQ10 is of key importance in cell metabolism; in addition to its role in mitochondrial oxidative phosphorylation, it is a major endogenous antioxidant, and has a role in the metabolism of sulphides, lipids and amino acids. Given its importance in cell metabolism, it is unsurprising that secondary CoQ10 deficiency has been linked with a wide range of disorders. In this article, we have reviewed evidence of secondary CoQ10 deficiency in both common and less common disorders, and highlighted those disorders in which CoQ10 supplementation has been shown to be of significant clinical benefit.

show abstract

Coenzyme Q10 supplementation in non-alcoholic fatty liver disease: an overview

Cited by 4 publications

References 32 publications

Role of Oxidative Stress in Liver Disorders

Role of Oxidative Stress in Liver Disorders

Coenzyme Q10 and Immune Function: An Overview

Depletion and Supplementation of Coenzyme Q10 in Secondary Deficiency Disorders

Contact Info

Product

Resources

About