Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue

Abstract

Preoperative oral coenzyme Q(10) therapy in patients undergoing cardiac surgery increases myocardial and cardiac mitochondrial coenzyme Q(10) levels, improves mitochondrial efficiency, and increases myocardial tolerance to in vitro hypoxia-reoxygenation stress.

L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial

“…However, clinical trials that investigated the ability of coenzyme Q10 [29,30], NADH (reduced nicotinamide adenine dinucleotide) [31,32], and alpha-lipoic acid [33] to improve mitochondrial function have not shown consistent results. L-carnitine is a critical component for mitochondrial fatty acid oxidation, and its supplementation has been shown to improve quality of life and reduce fatigue-related symptoms in patients with chronic kidney disease, cancer, and chronic hepatitis [26,[34][35][36].…”

Emulsification of Coenzyme Q₁₀ Using Gum Arabic Increases Bioavailability in Rats and Human and Improves Food-Processing Suitability

“…There have been many reports of increased blood concentrations of CoQ10 following its administration (28,29). It has also been reported that CoQ10 is, for the most part, carried to the liver and then excreted through the bile duct, so that only part of the amount ingested is carried to other organs (30).…”

“…In a study in which 14 C-labeled CoQ10 was given intravenously to rats to investigate the distribution of exogenous CoQ10, radioactivity in the mitochondria-particularly in the inner membranes-increased with time for up to 72 h after administration and then remained stable for at least 22 d (31). Oral administration of CoQ10 to patients who underwent coronary bypass surgery increased CoQ10 levels in the mitochondrial fraction of the heart (29). Further investigation is necessary to reveal the details of CoQ10 distribution.…”

Ubiquinol (Reduced CoQ10): A novel yet ubiquitous nutrient for heart disease

“…Supplementation with either ubiquinol or ubiquinone increases ubiquinol levels in plasma lipoproteins and the heart and thereby enhances resistance of LDL to free radical oxidation [7] and cardiac ATP production [8] . The higher bioavailability and biological activity of ubiquinol however, increases its beneficial effects [2] .…”