Coevolution: Mankind and Microbes

Mitscher, Lester A.

doi:10.1021/np078017j

Cited by 22 publications

(26 citation statements)

References 80 publications

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“…It is well known that in past years, infection rates have increased and antibiotic resistance has become an increasing therapeutic problem [11, 12]. In addition a greater interest in the antioxidant activity of plant extracts exists because of free radicals (e.g., reactive oxygen species) that can be responsible for several diseases, for example, heart disease, stroke, arteriosclerosis and cancer, as well as the aging process [13].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antioxidant Activities of Plants from Northeast of Mexico

Salazar‐Aranda

Pérez-López

López-Arroyo

et al. 2011

Evidence-Based Complementary and Alternative Medicine

105

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Traditional medicine has a key role in health care worldwide. Obtaining scientific information about the efficacy and safety of the plants from our region is one of the goals of our research group. In this report, 17 plants were selected and collected in different localities from northeast Mexico. The dried plants were separated into leaves, flowers, fruit, stems, roots and bark. Each part was extracted with methanol, and 39 crude extracts were prepared. The extracts were tested for their antimicrobial activity using three Gram-negative bacterial strains (Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii), three Gram-positive bacterial strains (Enterococcus faecalis and two Staphylococcus aureus strains), and seven clinically isolated yeasts (Candida albicans, C. krusei, C. tropicalis, C. parapsilosis and C. glabrata); their antioxidant activity was tested using a DPPH free radical assay. No activity against Gram-negative bacteria was observed with any extract up to the maximum concentration tested, 1000 μg ml−1. We report here for the first time activity of Ceanothus coeruleus against S. aureus (flowers, minimal inhibitory concentration (MIC) 125 μg ml−1), C. glabrata (MICs 31.25 μg ml−1) and C. parapsilosis (MICs between 31.25 and 125 μg ml−1); Chrysanctinia mexicana against C. glabrata (MICs 31.25 μg ml−1); Colubrina greggii against E. faecalis (MICs 250 μg ml−1) and Cordia boissieri against C. glabrata (MIC 125 μg ml−1). Furthermore, this is the first report about antioxidant activity of extracts from Ceanothus coeruleus, Chrysanctinia mexicana, Colubrina greggii and Cyperus alternifolius. Some correlation could exist between antioxidant activity and antiyeast activity against yeasts in the species Ceanothus coeruleus, Schinus molle, Colubrina greggii and Cordia boissieri.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antioxidant Activities of Plants from Northeast of Mexico

Salazar‐Aranda

Pérez-López

López-Arroyo

et al. 2011

Evidence-Based Complementary and Alternative Medicine

105

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“…The gravity of this problem is becoming apparent as resistant infections once limited to hospitals are spreading to the general community (Marshall 2008). Some experts even foreshadow a fast return to the helpless pre-antibiotic days (Ash 1996; Mitscher 2008; Nathan 2004) as the pipeline of last resort drugs runs dry and antibiotic development amongst major pharmaceutical companies is at an all time low (Jarvis 2008). …”

Section: Introductionmentioning

confidence: 99%

Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

et al. 2009

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The recent rise in drug resistance found amongst community acquired infections has sparked renewed interest in developing antimicrobial agents that target resistant organisms and limit the natural selection of immune variants. Recent discoveries have shown that iron uptake systems in bacteria and fungi are suitable targets for developing such therapeutic agents. The use of siderophore-drug conjugates as "Trojan Horse" drug delivery agents has attracted particular interest in this area. This review will discuss efforts in our research group to study the salmycin class of "Trojan Horse" antibiotics. Inspired by the natural design of the salmycins, a series of desferridanoxamine-antibiotic conjugates were synthesized and tested in microbial growth inhibition assays. The results of these studies will be related to understanding the role of drug release in siderophore-mediated drug delivery with implications for future siderophore-drug conjugate design.

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“…It is well known that in past years, infection rates have increased and antibiotic resistance has become an increasing therapeutic problem. 8,9 Due to the presence of free radicals i.e the antioxidant activity of the plant extracts that can be responsible for many diseases. Diseases like kidney problems, the ageing process, heart stroke and cancer as well.In addition, a greater interest in the antioxidant activity of plant extracts exists because of free radicals (e.g., reactive oxygen species) that can be responsible for several diseases, for example, heart disease, stroke, arteriosclerosis and cancer, as well as the aging process.…”

Section: Introductionmentioning

confidence: 99%

"PHYTOCHEMICAL INVESTIGATION OF DIFFERENT SOLVENT EXTRACTS OF Berberis lycium FRUITS"

2018

RJC

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Plants are biosynthetic laboratories for many useful compounds those are playing important role in human health. Ingredients of some medicinal plants are very much effective against bacterial and fungal growth and can be used to minimize their activities. The present work was carried out to study the antimicrobial activity of the aqueous, ethanolic, Dimethyl formamide, propanol-2 and n-hexane extracts of the root, fruit and flower of Berberis lycium belonging to the family of Berberidaceae, against different strains of bacteria and fungi.A study was conducted to assess the possible affects of Berberis lycium against the selected 5 bacteria and 3 fungi.The study revealed that the fruit extract possessed a good antifungal property in comparison to the other extract of the plant and this can be used in the further study for future in medicines.

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Coevolution: Mankind and Microbes

Cited by 22 publications

References 80 publications

Antimicrobial and Antioxidant Activities of Plants from Northeast of Mexico

Antimicrobial and Antioxidant Activities of Plants from Northeast of Mexico

Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

"PHYTOCHEMICAL INVESTIGATION OF DIFFERENT SOLVENT EXTRACTS OF Berberis lycium FRUITS"

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