Coevolution of self-fertilization and inbreeding depression I. Mutation-selection balance at one and two loci

Uyenoyama, Marcy K.; Waller, Donald M.

doi:10.1016/0040-5809(91)90045-h

Cited by 142 publications

(120 citation statements)

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“…Mating-system evolution Within-population variation in outcrossing rates has the potential to influence the coevolution between inbreeding depression and mating system through lineage specific purging of inbreeding depression (Uyenoyama and Waller, 1991). A previous study on the same G. achilleifolia population studied herein showed an association between levels of inbreeding depression and herkogamy (Takebayashi and Delph, 2000), which may be the outcome of such purging.…”

Section: Effects Of Herkogamy On Outcrossing Ratementioning

confidence: 99%

“…Variation in inbreeding history may potentially result in lineage-specific purging of genetic load and consequently different magnitudes of inbreeding depression among lineages within populations. Through this process, genetic associations may develop between loci controlling outcrossing rate and viability loci that cause inbreeding depression (Uyenoyama and Waller, 1991). Theoretically, such genetic associations can alter the balance between the costs and benefits of outcrossing, influencing the spread of morphological or genetic traits that control the outcrossing rate.…”

Section: Introductionmentioning

confidence: 99%

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Effect of variation in herkogamy on outcrossing within a population of Gilia achilleifolia

2005

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The diverse features of floral morphology are often thought to be well-designed mechanisms to manipulate plant mating systems. We evaluated the effectiveness of one such mechanism, anther-stigma separation (herkogamy), in controlling variation in the level of outcrossing among plants in a population of Gilia achilleifolia. Variation in outcrossing rates within populations has the potential to influence the coevolution between inbreeding depression and mating system. Using four polymorphic allozymes, we compared the outcrossing-rate estimates of two groups of individuals under natural conditions: one group with low herkogamy and another with high herkogamy. The high herkogamy group had a higher outcrossing rate (0.572) than the low herkogamy group (0.335). This suggests that the withinpopulation variation in outcrossing rate could potentially cause the previously observed association between herkogamy and inbreeding depression (Takebayashi and Delph, 2000). A previous study of floral traits among G. achilleifolia populations failed to detect a relationship between herkogamy and outcrossing rate, demonstrating that the functionality of traits may be obscured in amongpopulation studies as a consequence of uncontrolled environmental variation. Additionally, the effect of herkogamy on outcrossing rate in delayed selfers such as G. achilleifolia may be particularly prominent when pollinator availability is low. Our population-level estimate of outcrossing rate (0.444) was somewhat lower than an estimate from the same population, 15 years prior to our study (0.75), suggesting that pollinator availability may fluctuate among years. Both within-year and among-year variation in the outcrossing rate may have a strong influence on matingsystem evolution.

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Section: Effects Of Herkogamy On Outcrossing Ratementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of variation in herkogamy on outcrossing within a population of Gilia achilleifolia

2005

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“…Nevertheless, the effects of associations between loci on the evolution of mating systems remain little explored (but see Kamran-Disfani and Agrawal 2014). Besides affecting inbreeding depression, between-locus associations may modulate the advantage of selfers due to more efficient purging (e.g., Uyenoyama and Waller 1991;Epinat and Lenormand 2009) and possibly generate additional selective forces acting on a modifier locus affecting the selfing rate. These effects are still waiting for analytical exploration.…”

Section: Interference In Inbred Populationsmentioning

confidence: 99%

Effects of Interference Between Selected Loci on the Mutation Load, Inbreeding Depression, and Heterosis

Roze

2015

Genetics

126

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A classical prediction from single-locus models is that inbreeding increases the efficiency of selection against partially recessive deleterious alleles (purging), thereby decreasing the mutation load and level of inbreeding depression. However, previous multilocus simulation studies found that increasing the rate of self-fertilization of individuals may not lead to purging and argued that selective interference among loci causes this effect. In this article, I derive simple analytical approximations for the mutation load and inbreeding depression, taking into account the effects of interference between pairs of loci. I consider two classical scenarios of nonrandomly mating populations: a single population undergoing partial selfing and a subdivided population with limited dispersal. In the first case, correlations in homozygosity between loci tend to reduce mean fitness and increase inbreeding depression. These effects are stronger when deleterious alleles are more recessive, but only weakly depend on the strength of selection against deleterious alleles and on recombination rates. In subdivided populations, interference increases inbreeding depression within demes, but decreases heterosis between demes. Comparisons with multilocus, individual-based simulations show that these analytical approximations are accurate as long as the effects of interference stay moderate, but fail for high deleterious mutation rates and low dominance coefficients of deleterious alleles.KEYWORDS deleterious mutation; multilocus population genetics; population structure; selective interference; self-fertilization A CCORDING to current estimates of spontaneous deleterious mutation rates in multicellular organisms (e.g., Baer et al. 2007;Haag-Liautard et al. 2007;Keightley 2012) and estimated distributions of fitness effects of these mutations (e.g., Eyre-Walker and Keightley 2007;Keightley and Eyre-Walker 2007; Boyko et al. 2008;Haddrill et al. 2010), individuals may typically carry large numbers (possibly up to thousands) of deleterious alleles. Possible consequences of this load of deleterious mutations have been discussed since the early ages of theoretical population genetics (e.g., Haldane 1937). In particular, it may reduce population mean rates of fecundity and viability, thereby increasing vulnerability to extinction (Lynch et al. 1995a, b). It may also affect a number of evolutionary processes, such as the evolution of sex or mating systems: for example, the fact that deleterious alleles are often partially recessive generates inbreeding depression, favoring outcrossing over self-fertilization (e.g., Lande and Schemske 1985; Charlesworth and Charlesworth 1987; Charlesworth 2006).In very large, panmictic populations and in the absence of epistasis between mutations, genetic associations between deleterious alleles at different loci should remain weak and may be neglected. In diploids, and assuming that the dominance coefficient of deleterious alleles is significantly greater than zero, the mutation load (reduction i...

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“…Fourth, genes causing large increases in the selting rate can increase in frequency even in the presence of high levels of inbreeding depression (Lande and Schemske 1985;Holsinger 1988). Fifth, partial linkage between a selected locus (Uyenoyama and Waller 1991) or many selected loci (Charlesworth et al 1992) and a locus determining the selting rate can reduce the chance that selting will evolve. Partial linkage between selected loci themselves also decreases inbreeding depression slightly (Charlesworth et al 1992).…”

mentioning

confidence: 99%

“…Furthermore, higher (more nearly additive) dominance levels flatten the relationship between equilibrium inbreeding depression and the selting rate. Uyenoyama and Waller (1991) investigated a model in which inbreeding depression was caused by mutation at a single locus (in diploids). They distinguished their approach from that of Charlesworth et al (1990Charlesworth et al ( , 1991 as involving true coevolutionary dynamics rather than serial, stepwise changes in selting and inbreeding depression.…”

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confidence: 99%

CORRELATED EVOLUTION OF SELF-FERTILIZATION AND INBREEDING DEPRESSION: AN EXPERIMENTAL STUDY OF NINE POPULATIONS OFAMSINCKIA(BORAGINACEAE)

Johnston

Schoen

1996

Evolution

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Abstract.-The relation between inbreeding depression and rate of self-fertilization was studied in nine natural populations of the annual genus Amsinckia. The study included two clades (phylogenetic lineages) in which small-flowered, homostylous populations or species are believed to have evolved from large-flowered, heterostylous, self-compatible ones. In one lineage the small-flowered species is tetraploid with disomic inheritance. Rates of self-fertilization were 25% to 55% in the four large-flowered, heterostylous populations; 72% in a large-flowered but homostylous population; and greater than 99.5% in the four small-flowered, homostylous populations, which produce seed autonomously. When present, inbreeding depression occurred in the fertility but not the survival components of fitness. Using a cumulative fitness measure incorporating both survival and fertility (flower number), we found inbreeding depression to be lower in the four very highly self-fertilizing populations than in the five intermediate ones. The Spearman rank correlation between inbreeding depression and selfing rate for the nine populations was -0.50, but was not statistically significant (P = 0.12). Inbreeding depression was greater in the two tetraploid populations than in the very highly self-fertilizing, diploid ones. Phenotypic stability of progeny from self-fertilization tended to be higher in populations with lower inbreeding depression. We conclude that levels of self-fertilization and inbreeding depression in Amsinckia are determined more by other factors than by each other. Estimates of mutation rates and dominance coefficients of deleterious alleles, obtained from a companion study of the four highly self-fertilizing populations, suggest that a strong relationship may not be expected. We discuss the relationship of the present results to current theory of the coevolution of selffertilization and inbreeding depression.

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Coevolution of self-fertilization and inbreeding depression I. Mutation-selection balance at one and two loci

Cited by 142 publications

References 32 publications

Effect of variation in herkogamy on outcrossing within a population of Gilia achilleifolia

Effect of variation in herkogamy on outcrossing within a population of Gilia achilleifolia

Effects of Interference Between Selected Loci on the Mutation Load, Inbreeding Depression, and Heterosis

CORRELATED EVOLUTION OF SELF-FERTILIZATION AND INBREEDING DEPRESSION: AN EXPERIMENTAL STUDY OF NINE POPULATIONS OFAMSINCKIA(BORAGINACEAE)

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