Bacillus strains have long been widely and successfully used as the polyfunctional biologics’ basis in various systems for crops cultivation and protection. The research goal was to evaluate application effect from experimental prototypes of multirecycled polyfunctional biologics based on Bacillus subtilis I-5/12–23 together with compost in potato organic farming. A significant stimulation of potato plants Udacha variety growth and development up to the flowering phase was observed regardless of the growing season hydrothermal conditions. The stimulation was by the additive effect of joint biologics and compost use in proportion to its dose. The multirecycled substrate-associated and liquid polyfunctional biologics prototypes together with compost almost doubled the potato tubers biological yield compared to the control regardless the growing season conditions. In the flowering phase, the biological efficacy with respect to the potato fungal diseases incidence and development was 90% under optimal hydrothermal conditions and up to 75% under drought conditions. At the vegetation end the efficacy in the potato fungal diseases development reached 70% (compost efficiency itself more than 45%) regardless of the vegetation period conditions. Four-year scientific and producing approbation of the technological application rules for the biologics’ prototypes based on B. subtilis I5-12/23 and compost developed for the North-West region’s various weather and climatic conditions showed their high efficacy in protection the organic potato. Disease incidence on plants decreased about 80%, on tubers about 50%, their quality improved, and the marketable products yield increase at 9 t ha− 1 (3 t ha− 1, on average). The application’s technological rules optimizing for various weather and climatic conditions is carried out by changing the consumption norms of protection means in proportion to the limiting factors. Multirecycled polyfunctional biologics prototypes combining the properties of biopesticides, biofertilizers and inoculants can be used to ensure stable organic potato production.