Coexistence of Chronic Lymphocytic Leukemia and Myeloproliferative Neoplasm

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world. Host immune surveillance caused mainly by the disease itself is speculated to be responsible for high incidence of secondary neoplasms. However, the simultaneous occurrence of CLL and myeloproliferative disorder in the same patient is extremely rare. In the present report, a case of an 81-year-old man who was diagnosed with chronic lymphocytic leukemia and concomitant essential thrombocythemia is presented. We describe the morphologic, immunophenotypic, cytogenetic, and molecular findings in this patient. We also review the current literature.

Second malignancies in Philadelphia-positive and -negative myeloproliferative neoplasms: A single center study

“…In patients with MPNs, coexisting CLL, Non-Hodgkin's Lymphoma, multiple myeloma cases are also available in literature (15)(16)(17)(18). In this study, cancer incidence rate was found higher (1149.8/100.000 person-years for males and 540.8/100.000 person-years for females with MPNs) compared with IARC data of Turkey (rate of noncutaneous cancers standardized for age is 245.7/100.000 person-years for males, and 157.5/100.000 person-years for females).…”

Authors and Editors of Scholarly Journals Should be Aware of Plagiarism and Its Consequences

“…Possible pathogenetic mechanisms for their occurrence might include the independent proliferation of 2 distinct cell lines, bi-lineage development of a common pluripotent stem cell proliferation, or an accidental situation. 4 Some hypothesize that initial “trigger hits” occur in pre-JAK2 progenitor pluripotent hematopoietic stem cells, which makes them genetically labile, and they differentiate into myeloid and lymphoid lineages, with the myeloid cells gaining JAK2 mutation while lymphoid cells undergo malignant transformation prior to the loss of Zap 70 mutation. 5 …”