Coexistence of condyloma acuminatum and extramammary Paget’s disease on penis and scrotum: A rare case report

Abstract

Rationale: Extramammary Paget’s disease (EMPD) is a rare skin cancer that commonly occurs in sites rich in apocrine glands, such as perineum, vulva, axilla, scrotum, and penis. On the other hand, condyloma acuminatum (CA; also referred to as anogenital warts) is a common benign neoplasm caused by human papillomavirus. Few cases of coexistent EMPD and CA have been reported because of the rarity of the condition. Patient concerns and diagnosis: A 72-year-old man with a genital mass, which appeared to be composed of multiple papillomatous masses, was referred for surgical resection. The lesion was first noticed 6 months previously and grew rapidly. CO2 ablative laser therapy was performed twice at a primary clinic, but the mass recurred. Intervention and outcomes: Excisional biopsy revealed the presence of coexistent EMPD and CA. Additional wide excision was performed, and postoperative biopsy confirmed no residual tumor. Two years after surgery, no recurrence had occurred. Lessons: CA can co-occur with several types of skin malignancies, and a skin malignancy coexisting with CA is difficult to diagnose visually. Therefore, even if a skin lesion in the genital region is considered to be CA, we recommend punch biopsy before treatment because it can benefit prognosiss.

Protruding mass in the pubis

“…Characteristic koilocytes are key histopathological features. A very few cases of coexistence of condyloma acuminatum and EMPD have been reported 4 . For this patient, no koilocytes were observed histologically and HPV DNA detection was negative using a commercial HPV genoarray diagnostic kit capable of 6 low‐risk HPVs and 15 high‐risk HPVs (HBGA‐21PKG, Hybribio, China).…”

“…A very few cases of coexistence of condyloma acuminatum and EMPD have been reported. 4 For this patient, no koilocytes were observed histologically and HPV DNA detection was negative using a commercial HPV genoarray diagnostic kit capable of 6 low-risk HPVs and 15 high-risk HPVs (HBGA-21PKG, Hybribio, China). Prompt biopsy and histological examination helps in the correct diagnosis and management.…”

Exophytischer Tumor am Mons pubis

“…Es wurden nur sehr wenige Fälle berichtet, in denen Condylomata acuminata und EMPD gleichzeitig auftraten. 4 Bei unserem Patienten wurden histologisch keine Koilozyten festgestellt, und der HPV-DNA-Nachweis war mit einem kommerziellen Genarray-Diagnosekit, der 6 Niedrigrisiko-und 15 Hochrisiko-HPVs erkennen kann (HBGA-21PKG, Hybribio, China), verlief negativ. Eine zeitnahe Biopsie und histologische Untersuchung helfen bei der richtigen Diagnose und Behandlung.…”

“…Charakteristische Koilozyten sind die wichtigsten histopathologischen Merkmale. Es wurden nur sehr wenige Fälle berichtet, in denen Condylomata acuminata und EMPD gleichzeitig auftraten 4 . Bei unserem Patienten wurden histologisch keine Koilozyten festgestellt, und der HPV‐DNA‐Nachweis war mit einem kommerziellen Genarray‐Diagnosekit, der 6 Niedrigrisiko‐ und 15 Hochrisiko‐HPVs erkennen kann (HBGA‐21PKG, Hybribio, China), verlief negativ.…”