Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma: The influence of lymph node metastasis

Kim, Sang Soo; Lee, Byung‐Joo; Lee, Jin Choon; Kim, Seong-Jang; Jeon, Yun Kyung; Kim, Mi Ra; Huh, Jeong Eun; Mok, Ji Young; Kim, Bo Hyun; Kim, In Joo

doi:10.1002/hed.21594

Cited by 85 publications

(78 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients with chronic lymphocytic thyroiditis are considered to be more likely to exhibit thyroid carcinoma compared with patients without this condition (33,34). A previous report indicated that coexisting chronic lymphocytic thyroiditis in patients with papillary thyroid carcinoma had an inverse correlation with CLNM (35). The present study demonstrated that the frequency of CLNM was 48.2% (41/85 cases) in the chronic lymphocytic thyroiditis group, which was reduced compared with the control group.…”

Section: Discussionsupporting

confidence: 51%

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

et al. 2015

View full text Add to dashboard Cite

Abstract. Central lymph node metastasis (CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of the present study was to investigate the risk factors associated with CLNM in clinical lateral cervical lymph node-negative (cN0) PTMC in Eastern China. A total of 392 patients with confirmed PTMC by histological examination who underwent thyroidectomy and central neck lymph node dissection (CND) between May 2011 and October 2012 at the First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China) were enrolled. The clinicopathological and ultrasonographic data from the patients were analyzed retrospectively. A scoring system was developed on the basis of independent predictive factors for CLNM. Male gender, age <45 years, maximum tumor diameter >5 mm, lower lobe location, multifocal carcinoma with total tumor diameter >10 mm and extracapsular spread were independent predictive factors for CLNM according to logistic regression analysis. The clinicopathological score was statistically significant, with an index point ≥2 indicating CLNM with 86.2% sensitivity and 70.4% specificity. The findings of the present study indicate that CND may be recommended to be routinely performed when the clinicopathological index point ≥2.

show abstract

Section: Discussionsupporting

confidence: 51%

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Patients with Hashimoto's thyroiditis are believed to be at higher risk for PTC compared with patients without Hashimoto's thyroiditis [23]. A few previous reports have shown that the cases of PTC coexisted with Hashimoto's thyroiditis are more multicentric than those without Hashimoto's thyroiditis [24]. And Kim et al [25] reported that multifocality and bilaterality are more frequent with the coexistence of Hashimoto's thyroiditis and PTC including PTMC, consistent with our results.…”

Section: Discussionsupporting

confidence: 82%

Predictive Factors for Incidental Contralateral Carcinoma in Patients with Unilateral Micropapillary Thyroid Carcinoma

et al. 2012

Self Cite

View full text Add to dashboard Cite

Background: Whether thyroid lobectomy alone is a sufficient treatment for papillary thyroid microcarcinoma (PTMC) remains controversial. The aim of this study is to evaluate the predictive factors for incidental contralateral carcinoma in patients confirmed of unilateral PTMC preoperatively. Methods: Between January 2007 and December 2009, 393 patients underwent thyroid surgery for unifocal and unilateral PTMC preoperatively at Pusan National University Hospital. A total thyroidectomy with central neck dissection was routinely performed for these patients during this study period. Results: Among the 393 cases in the cohort, 77 patients (19.6%) had incidental PTMC in the contralateral lobe. In patients with incidental contralateral carcinoma, there was higher prevalence in extrathyroid extension, occult ipsilateral carcinoma, pathologic Hashimoto's thyroiditis, and central lymph node metastasis compared to those without contralateral carcinoma. The mean tumor size also increased in patients with contralateral carcinoma. Multivariate logistic regression showed that extrathyroid extension (P = 0.049), occult ipsilateral carcinoma (P < 0.001), pathologic Hashimoto's thyroiditis (P = 0.038), and central lymph node metastasis (P = 0.002) were predictive factors for incidental contralateral carcinoma. Conclusion:In conclusion, multifocality in the ipsilateral lobe, central lymph node metastasis, extrathyroid extension, and Hashimoto's thyroiditis is associated with the presence of contralateral carcinoma. Thus, if these factors are found by preoperative and/or postoperative evaluation, total thyroidectomy or completion thyroidectomy is necessary for the treatment of PTMC. (Endocrinol Metab 27:194-199, 2012)

show abstract

“…Loh et al 24 reported that patients with PTC and chronic lymphocytic thyroiditis had a good prognosis, because the frequency of extrathyroid extension, nodal metastasis and distant metastasis was low. Kim et al 25 reported a negative association between the coexistence of chronic lymphocytic thyroiditis and central compartment LNM. In this study, 92 patients (31Á6%) had chronic lymphocytic thyroiditis, of which 39Á1% was found with central compartment LNM, the result was similar to Kim's report (LNM in chronic lymphocytic thyroiditis was identified in 52Á5%).…”

mentioning

confidence: 99%

Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma

Yang

Chen

et al. 2014

Clinical Endocrinology

View full text Add to dashboard Cite

SummaryObjectives We aimed to determine the predictive factors for central compartment lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC). Design and patients We undertook a retrospective study of 291 patients treated for PTMC. The following criteria were assessed to predict the presence of central compartment LNM: sex, age, tumour multifocality, tumour size, tumour bilaterality, extracapsular spread (ECS), lateral neck LNM, coexistence of chronic lymphocytic thyroiditis, BRAF V600E mutation and ultrasonography (US) features. Univariate and multivariate analyses were performed to identify clinicopathological characteristics and US findings in predicting central compartment LNM from PTMC.Results The central compartment LNM affected 133 (45Á7%) of 291 patients. With use of univariate and multivariate analyses, male gender (OR 2Á020; P = 0Á039), tumour size (>5 mm) (OR 3Á687; P = 0Á015), ESC (OR 2Á330; P = 0Á044), lateral LNM (OR 15Á075; P = 0Á000) and BRAF V600E mutation (OR 2Á464; P = 0Á000) were independently correlated with central compartment LNM. Age, tumour multifocality, tumour bilaterality, coexistence of chronic lymphocytic thyroiditis and US characteristics were not significantly related to the presence of central compartment LNM. We have also developed a nomogram to predict the probability of central compartment LNM for an individual patient. The sensitivity was 71Á9% and specificity was 70Á3%, with an under the receiver operating characteristic (ROC) curve of 0Á772.Conclusions A prophylactic neck dissection of the central compartment should be considered particularly in PTMC patients with male gender, a >5 mm tumour size, ECS of the tumours, lateral LNM and positive BRAF V600E mutation.

show abstract

Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma: The influence of lymph node metastasis

Abstract: Coexisting Hashimoto's thyroiditis in patients with papillary thyroid carcinoma was identified as a negative independent predictive factor for central lymph node metastasis.

Cited by 85 publications

References 29 publications

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

Predictive Factors for Incidental Contralateral Carcinoma in Patients with Unilateral Micropapillary Thyroid Carcinoma

Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma

Contact Info

Product

Resources

About