Coexistence of hashimotos thyroiditis with papillary thyroid carcinoma: a single center experience

Abstract

Aim: A positive correlation between Hashimoto's thyroiditis (HT) and papillary thyroid cancer (PTC) is determinated in studies based on histopathological examination of the thyroidectomy materials, but this correlation is not determinated in studies based on Fine Niddle Aspiration Biopsy (FNAB). In this study, the histopathologic results of bilateral total thyroidectomy (TT) specimens were studied for outcomes of PTC association with HT and its relationship with clinical and pathological prognostic factors. Material and Methods: Demographic data, thyroidectomy indications and pathology results of 568 patients with performed TT between April 2009 March 2016 were collected. PTC identified patients, were evaluated in terms of HT association. In these patients, the prognostic factors were evaluated according to coexistence of HT. Results: The average age of the patients was 48.9 years and M / F ratio was 1: 3.5. HT was detected in 36 patients and PTCin 121 patients by histopathological examinations. PTC incidence in HT group was higher than non-HT group. (p = 0.025). HT incidence in PTC group was higher than non-PTC group (p = 0.025).When compared in terms of demographic and prognostic data of PTC patiens,no statistically significant difference was detected between PTC with and without HT groups. Conclusion: PTC detection rate in patients with HT, who has indication for thyroidectomy is higher than non-HT patients. HT patients (especially female sex), should be followed closely, in terms of the development of malignant nodules.

Association between chronic lymphocityc thyroiditis and papillary thyroid carcinoma: Systematic review and meta-analysis of studies on surgical specimens

“…After exclusion of duplicate articles, the literature search strategy identified 3597 potentially eligible articles. A total of 36 articles met the inclusion criteria, that is, their main purpose was to compare the prevalence of PTC in two groups of surgical specimens, categorized according to the presence or absence of histological changes compatible with CLT; however, 11 articles were excluded in which, after a thorough review of their methodology, it was possible to conclude that not all the specimens available during the study period were included in the statistical analysis [36][37][38][39][40][41][42][43][44][45][46] ; on the other hand, in three of the articles [47][48][49] , despite the inclusion of all the specimens available during the study period, after the application of the Chi-square test, the count of expected phenomena was lower than the minimum, which suggested that the sample assessed could be insufficient to perform an inferential analysis, which is why they were excluded. Finally, 22 articles 50-71 were included in which, in addition to meeting the inclusion criteria, it was possible to perform an inferential analysis, with the lowest possible source of selection bias (Figure 1).…”